Synthesis and Hypoglycemic Activity of New Nicotinonitrile-Furan Molecular Hybrids

Synthesis of some new nicotinonitrile-furan hybrids and evaluation of their hypoglycemic activity. Methods: Three-component pyridine synthesis based on tandem reactions of Knoevenagel condensationMichael addition-heterocyclization using furfural, cyanothioacetamide and Meldrum’s acid (or allyl aceto...

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主要な著者:	Dotsenko, V. V., Доценко, В. В., Aksenov, N. A., Аксенов, Н. А., Aksenova, I. V., Аксенова, И. В.
フォーマット:	Статья
言語:	English
出版事項:	2024
主題:	Cyanothioacetamide Furfural Hypoglycemic effects Partially saturated nicotinonitriles Steroid-induced diabetes mellitus
オンライン･アクセス:	https://dspace.ncfu.ru/handle/123456789/27432
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spelling	ir-123456789-274322024-04-18T12:57:00Z Synthesis and Hypoglycemic Activity of New Nicotinonitrile-Furan Molecular Hybrids Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. Cyanothioacetamide Furfural Hypoglycemic effects Partially saturated nicotinonitriles Steroid-induced diabetes mellitus Synthesis of some new nicotinonitrile-furan hybrids and evaluation of their hypoglycemic activity. Methods: Three-component pyridine synthesis based on tandem reactions of Knoevenagel condensationMichael addition-heterocyclization using furfural, cyanothioacetamide and Meldrum’s acid (or allyl acetoacetate) as the starting reagents. Hypoglycemic effects was studied on the model of dexamethasone-induced diabetes mellitus in rats. Results and Discussion: All four new compounds (XX–XXIII) were characterized by spectral methods and found to have remarkable hypoglycemic activity. Conclusions: Some new nicotinonitrile-furan hybrids were prepared and tested in vivo for hypoglycemic activity. The compound (XX) showed more potent hypoglycemic effect that of the reference drug metformin without pronounced hepatotoxicity. 2024-04-18T12:54:52Z 2024-04-18T12:54:52Z 2024 Статья Tilchenko, D.A., Bibik, E.Y., Dotsenko, V.V., Krivokolysko, S.G., Frolov, K.A., Aksenov, N.A., Aksenova, I.V. Synthesis and Hypoglycemic Activity of New Nicotinonitrile-Furan Molecular Hybrids // Russian Journal of Bioorganic Chemistry. - 2024. - 50 (2). - pp. 554-570. - DOI: 10.1134/S1068162024020183 https://dspace.ncfu.ru/handle/123456789/27432 en Russian Journal of Bioorganic Chemistry application/pdf application/pdf
institution	СКФУ
collection	Репозиторий
language	English
topic	Cyanothioacetamide Furfural Hypoglycemic effects Partially saturated nicotinonitriles Steroid-induced diabetes mellitus
spellingShingle	Cyanothioacetamide Furfural Hypoglycemic effects Partially saturated nicotinonitriles Steroid-induced diabetes mellitus Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. Synthesis and Hypoglycemic Activity of New Nicotinonitrile-Furan Molecular Hybrids
description	Synthesis of some new nicotinonitrile-furan hybrids and evaluation of their hypoglycemic activity. Methods: Three-component pyridine synthesis based on tandem reactions of Knoevenagel condensationMichael addition-heterocyclization using furfural, cyanothioacetamide and Meldrum’s acid (or allyl acetoacetate) as the starting reagents. Hypoglycemic effects was studied on the model of dexamethasone-induced diabetes mellitus in rats. Results and Discussion: All four new compounds (XX–XXIII) were characterized by spectral methods and found to have remarkable hypoglycemic activity. Conclusions: Some new nicotinonitrile-furan hybrids were prepared and tested in vivo for hypoglycemic activity. The compound (XX) showed more potent hypoglycemic effect that of the reference drug metformin without pronounced hepatotoxicity.
format	Статья
author	Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В.
author_facet	Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В.
author_sort	Dotsenko, V. V.
title	Synthesis and Hypoglycemic Activity of New Nicotinonitrile-Furan Molecular Hybrids
title_short	Synthesis and Hypoglycemic Activity of New Nicotinonitrile-Furan Molecular Hybrids
title_full	Synthesis and Hypoglycemic Activity of New Nicotinonitrile-Furan Molecular Hybrids
title_fullStr	Synthesis and Hypoglycemic Activity of New Nicotinonitrile-Furan Molecular Hybrids
title_full_unstemmed	Synthesis and Hypoglycemic Activity of New Nicotinonitrile-Furan Molecular Hybrids
title_sort	synthesis and hypoglycemic activity of new nicotinonitrile-furan molecular hybrids
publishDate	2024
url	https://dspace.ncfu.ru/handle/123456789/27432
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Synthesis and Hypoglycemic Activity of New Nicotinonitrile-Furan Molecular Hybrids

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