Synthesis and Hypoglycemic Activity of New Nicotinonitrile-Furan Molecular Hybrids

Synthesis and Hypoglycemic Activity of New Nicotinonitrile-Furan Molecular Hybrids

Synthesis of some new nicotinonitrile-furan hybrids and evaluation of their hypoglycemic activity. Methods: Three-component pyridine synthesis based on tandem reactions of Knoevenagel condensationMichael addition-heterocyclization using furfural, cyanothioacetamide and Meldrum’s acid (or allyl aceto...

Full description

Saved in:

Bibliographic Details
Main Authors:	Dotsenko, V. V., Доценко, В. В., Aksenov, N. A., Аксенов, Н. А., Aksenova, I. V., Аксенова, И. В.
Format:	Статья
Language:	English
Published:	2024
Subjects:	Cyanothioacetamide Furfural Hypoglycemic effects Partially saturated nicotinonitriles Steroid-induced diabetes mellitus
Online Access:	https://dspace.ncfu.ru/handle/123456789/27432
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

New Hybrid Molecules Based on Sulfur-Containing Nicotinonitriles: Synthesis, Analgesic Activity in Acetic Acid-Induced Writhing Test, and Molecular Docking Studies
by: Dotsenko, V. V., et al.
Published: (2022)

New 4-(2-Furyl)-1,4-dihydronicotinonitriles and 1,4,5,6-Tetrahydronicotinonitriles: synthesis, structure, and analgesic activity
by: Dotsenko, V. V., et al.
Published: (2021)

Synthesis, structure, and analgesic activity of 4-(5-Cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic acids ethyl esters
by: Dotsenko, V. V., et al.
Published: (2022)

Development of the prescribed foodstuff composition for diabetes mellitus prevention
by: Sadovoy, V. V., et al.
Published: (2018)

Hemorhelogic profile and microcirculatory hemostasis in patients with cerebrovascular disease in diabetes mellitus
by: Anfinogenova, O. I., et al.
Published: (2021)

Recent advances in the chemistry of thieno[2,3-b]pyridines 1. Methods of synthesis of thieno[2,3-b]pyridines
by: Dotsenko, V. V., et al.
Published: (2020)

THE ROLE OF OXIDATIVE STRESS IN THE PATHOGENESIS OF VASCULAR COMPLICATIONS IN CHILDREN WITH INSULINABLE SUGAR DIABETES
by: Nuzhnaya, C. V., et al.
Published: (2019)

Biochemical aspects of oxidative stress development in children with type 1 diabetes mellitus
by: Anfinogenova, O. I., et al.
Published: (2020)

COPD and Diabetes Mellitus: Down the Rabbit Hole
by: Uzdenov, R. M., et al.
Published: (2022)

Matrix metalloproteinases and their tissue inhibitors in the pathogenesis of periodontal diseases in type 1 diabetes mellitus
by: Anfinogenova, O. I., et al.
Published: (2021)

New possibilities of the Mannich reaction in the synthesis of N-, S,N-, and Se,N-heterocycles
by: Dotsenko, V. V., et al.
Published: (2019)

Synthesis and biological activity of 8-(dialkylamino)-3-aryl-6-oxo-2,4-dicyanobicyclo[3.2.1]octane-2,4-dicarboxylic acids diethyl esters
by: Dotsenko, V. V., et al.
Published: (2020)

A new synthetic approach to functionalized bicyclo[3.2.1]octanes
by: Dotsenko, V. V., et al.
Published: (2018)

JAW BONES MICROARCHITECTONICS AND MORPHOLOGY IN PATIENTS WITH DIABETES MELLITUS
by: Domenyuk, S., et al.
Published: (2023)

Reaction of ethoxymethylenemalonate with cyanothioacetamide in the presence of triethylamine: formation of 1,5-diamino-2,4-dicyano-5-thioxopenta-1,3-diene-1-thiolate and unexpected aminomethylation result
by: Dotsenko, V. V., et al.
Published: (2020)

Ultrastructure aspects of acquired resistance in plants under viral pathogenesis
by: Orobinskaya, V. N., et al.
Published: (2021)

Synthesis and structure of new 2,4-dicyano-6-oxo-3-phenylbicyclo[3.2.1]octane-2,4-dicarboxylates
by: Dotsenko, V. V., et al.
Published: (2020)

Partially explicit time discretization for time fractional diffusion equation
by: Alikhanov, A. A., et al.
Published: (2022)

Oxidation of 4,6-Dimethyl-2-thioxo-1,2-dihydropyridine-3-carbonitriles with Potassium Ferricyanide: Synthesis and Molecular Docking of Bis(pyrid-2-yl) Disulfides
by: Dotsenko, V. V., et al.
Published: (2024)

Synthesis of 4,6-disubstituted 2-thioxo-1,2-dihydropyridine-3-carbonitriles by the reaction of acetylenic ketones with cyanothioacetamide
by: Dotsenko, V. V., et al.
Published: (2019)

Synthesis, structure, and biological activity of 2,6-diazido-4-methylnicotinonitrile derivatives
by: Aksenov, N. A., et al.
Published: (2018)

Synthesis and properties of new fluorine-containing thieno[2,3-b]pyridine derivatives
by: Dotsenko, V. V., et al.
Published: (2019)

Synthesis and Structure of (2E)-3-Aryl(hetaryl)-2-[5-bromo-4-aryl(hetaryl)-1,3-thiazol-2-yl]acrylonitriles
by: Dotsenko, V. V., et al.
Published: (2021)

Oxidation of 2-Cyanothioacrylamides with Sodium Nitrite in Acidic Medium
by: Dotsenko, V. V., et al.
Published: (2022)

Variation in Composition of Biologically Active Substances in Flowers and Leaves of Achillea asiatica Serg. Plants Depending on the Region of Habitat
by: Lodygin, A. D., et al.
Published: (2024)

A new Approach to the synthesis of functional derivatives of 3-(4-Pyridinyl)-1H-indole and 4-s(1H-Indol-3-yl)thieno[2,3-b]pyridine
by: Dotsenko, V. V., et al.
Published: (2018)

Concerning partial discharge detection in cable lines using high-frequency sensors
by: Morozova, T. F., et al.
Published: (2023)

Nutritional supplement for control of diabetes
by: Selimov, M. A., et al.
Published: (2018)

Synthesis and Aminomethylation of 2-Amino-4-(2-chlorophenyl)-6-(dicyanomethyl)-1,4-dihydropyridine-3,5-dicarbonitrile N-Methylmorpholinium Salt
by: Dotsenko, V. V., et al.
Published: (2022)

Synthesis and In vivo Evaluation of Hepatoprotective Effects of Novel Sulfur-Containing 1,4-Dihydropyridines and 1,2,3,4-Tetrahydropyridines
by: Dotsenko, V. V., et al.
Published: (2023)

(2E,2′E)-2,2′-(1,2,4-Thiadiazole-3,5-diyl)bis[3-arylacrylonitriles]: Synthesis and Antidote Activity Towards 2,4-D Herbicide
by: Dotsenko, V. V., et al.
Published: (2023)

High seasonal variations of the radon exhalation from soil surface in the fault zones (Baikal and North Caucasus regions)
by: Shchitov, D. V., et al.
Published: (2020)

Bayesian decision making using partial data for fractured poroelastic media
by: Tyrylgin, A. A., et al.
Published: (2024)

Application of laboratory and X-Ray gentral studies un early diagnostics of metabolic disturbances of bone tissue in children with autoimmune diabetes mellitus
by: Rzhepakovsky, I. V., et al.
Published: (2019)

Partial learning using partially explicit discretization for multicontinuum/multiscale problems with limited observation: Language interactions simulation
by: Tyrylgin, A. A., et al.
Published: (2023)

Synthesis and analgesic activity of new heterocyclic cyanothioacetamide derivatives
by: Dotsenko, V. V., et al.
Published: (2021)

Effect of magnetic fields on the optical density of magnetic emulsions with low interfacial tension
by: Belykh, S. S., et al.
Published: (2022)

Mannich Reaction Involving 6-Amino-4-methyl-2-(thio)oxo-1,2-dihydropyridine-3,5-dicarbonitriles
by: Strelkov, V. D., et al.
Published: (2023)

Synthesis and properties of 4,6-Dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile and 3-Amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines
by: Dotsenko, V. V., et al.
Published: (2019)

Delayed fracture of martensitic steels during hydrogen saturation as a function of the initial austenitic grain size
by: Mishin, V. M., et al.
Published: (2022)