Synthetic biology approach revealed enhancement in haeme oxygenase-1 gene expression by codon pair optimization while reduction by codon deoptimization
Haem oxygenase-1 (HO-1) is a ubiquitously expressed gene involved in cellular homoeostasis, and its imbalance in expression results in various disorders. To alleviate such disorders, HO-1 gene expression needs to be modulated. Codon usage bias results from evolutionary forces acting on any nucleotid...
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| Médium: | Статья |
| Jazyk: | English |
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Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
2024
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| On-line přístup: | https://dspace.ncfu.ru/handle/123456789/28765 |
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