Chitosan-ricobendazole complex: Synthesis, characterization and anthelmintic activity
Synthesis, characterization and assessment of therapeutic efficacy of chitosan-ricobendazole complex were carried out for the first time in this work. Study of physico-chemical properties revealed the optimal ratio of chitosan: ricobendazole (30:4). Quantum chemical modeling set the optimal paramete...
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Elsevier B.V.
2024
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ir-123456789-291762024-10-30T12:21:15Z Chitosan-ricobendazole complex: Synthesis, characterization and anthelmintic activity Blinov, A. V. Блинов, А. В. Gvozdenko, A. A. Гвозденко, А. А. Golik, A. B. Голик, А. Б. Rekhman, Z. A. Рехман, З. А. Prasolova, A. V. Прасолова, А. В. Askerova, A. S. Аскерова, А. С. Kuznetsov, E. Кузнецов, Е. Nagdalian, A. A. Нагдалян, А. А. Helminthiasis Polysaccharides Sheep Synthesis, characterization and assessment of therapeutic efficacy of chitosan-ricobendazole complex were carried out for the first time in this work. Study of physico-chemical properties revealed the optimal ratio of chitosan: ricobendazole (30:4). Quantum chemical modeling set the optimal parameters for the formation of the chitosan-ricobendazole molecular system (E = −3765.26 kcal/mol, η = 0.127 eV), which was confirmed by Fourier-transform infrared spectroscopy. Scanning electron microscopy showed spherical particles of chitosan-ricobendazole complex ranging in size from 100 to 200 μm. Study of therapeutic efficiency was conducted on sheep with dicroceliosis. Notably, the therapeutic efficiency of the chitosan-ricobendazole complex (4 mg/kg of ricobendazole) reached 89 %, while the therapeutic efficiency of the commercial preparation ricazole (8 mg/kg of ricobendazole) was 92 %. Biochemical blood test indicated equivalent normalization of hematological parameters in sheep after treatment with ricazole and the chitosan-ricobendazole complex. Histological examination of infected sheep liver revealed that treatment with the chitosan-ricobendazole complex leads to a decrease in the number of helminth eggs with subsequent therapeutic effect on the severity of the disease. This proves the enhanced solubility of ricobendazole at a dosage of 4 mg/kg, active interaction of the components and relatively high bioavailability without increasing the release rate of ricobendazole. 2024-10-30T12:19:21Z 2024-10-30T12:19:21Z 2024 Статья Blinov A., Orobets V., Kastarnova E., Gvozdenko A., Golik A., Rekhman Z., Prasolova A., Askerova A., Kuznetsov E., Nagdalian A. Chitosan-ricobendazole complex: Synthesis, characterization and anthelmintic activity // International Journal of Biological Macromolecules. - 2024. - 280. - art. no. 135572. - DOI: 10.1016/j.ijbiomac.2024.135572 https://dspace.ncfu.ru/handle/123456789/29176 en International Journal of Biological Macromolecules application/pdf application/pdf Elsevier B.V. |
| institution |
СКФУ |
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Репозиторий |
| language |
English |
| topic |
Helminthiasis Polysaccharides Sheep |
| spellingShingle |
Helminthiasis Polysaccharides Sheep Blinov, A. V. Блинов, А. В. Gvozdenko, A. A. Гвозденко, А. А. Golik, A. B. Голик, А. Б. Rekhman, Z. A. Рехман, З. А. Prasolova, A. V. Прасолова, А. В. Askerova, A. S. Аскерова, А. С. Kuznetsov, E. Кузнецов, Е. Nagdalian, A. A. Нагдалян, А. А. Chitosan-ricobendazole complex: Synthesis, characterization and anthelmintic activity |
| description |
Synthesis, characterization and assessment of therapeutic efficacy of chitosan-ricobendazole complex were carried out for the first time in this work. Study of physico-chemical properties revealed the optimal ratio of chitosan: ricobendazole (30:4). Quantum chemical modeling set the optimal parameters for the formation of the chitosan-ricobendazole molecular system (E = −3765.26 kcal/mol, η = 0.127 eV), which was confirmed by Fourier-transform infrared spectroscopy. Scanning electron microscopy showed spherical particles of chitosan-ricobendazole complex ranging in size from 100 to 200 μm. Study of therapeutic efficiency was conducted on sheep with dicroceliosis. Notably, the therapeutic efficiency of the chitosan-ricobendazole complex (4 mg/kg of ricobendazole) reached 89 %, while the therapeutic efficiency of the commercial preparation ricazole (8 mg/kg of ricobendazole) was 92 %. Biochemical blood test indicated equivalent normalization of hematological parameters in sheep after treatment with ricazole and the chitosan-ricobendazole complex. Histological examination of infected sheep liver revealed that treatment with the chitosan-ricobendazole complex leads to a decrease in the number of helminth eggs with subsequent therapeutic effect on the severity of the disease. This proves the enhanced solubility of ricobendazole at a dosage of 4 mg/kg, active interaction of the components and relatively high bioavailability without increasing the release rate of ricobendazole. |
| format |
Статья |
| author |
Blinov, A. V. Блинов, А. В. Gvozdenko, A. A. Гвозденко, А. А. Golik, A. B. Голик, А. Б. Rekhman, Z. A. Рехман, З. А. Prasolova, A. V. Прасолова, А. В. Askerova, A. S. Аскерова, А. С. Kuznetsov, E. Кузнецов, Е. Nagdalian, A. A. Нагдалян, А. А. |
| author_facet |
Blinov, A. V. Блинов, А. В. Gvozdenko, A. A. Гвозденко, А. А. Golik, A. B. Голик, А. Б. Rekhman, Z. A. Рехман, З. А. Prasolova, A. V. Прасолова, А. В. Askerova, A. S. Аскерова, А. С. Kuznetsov, E. Кузнецов, Е. Nagdalian, A. A. Нагдалян, А. А. |
| author_sort |
Blinov, A. V. |
| title |
Chitosan-ricobendazole complex: Synthesis, characterization and anthelmintic activity |
| title_short |
Chitosan-ricobendazole complex: Synthesis, characterization and anthelmintic activity |
| title_full |
Chitosan-ricobendazole complex: Synthesis, characterization and anthelmintic activity |
| title_fullStr |
Chitosan-ricobendazole complex: Synthesis, characterization and anthelmintic activity |
| title_full_unstemmed |
Chitosan-ricobendazole complex: Synthesis, characterization and anthelmintic activity |
| title_sort |
chitosan-ricobendazole complex: synthesis, characterization and anthelmintic activity |
| publisher |
Elsevier B.V. |
| publishDate |
2024 |
| url |
https://dspace.ncfu.ru/handle/123456789/29176 |
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