Assessment of biocompatibility and toxicity of basic copper carbonate nanoparticles stabilized with biological macromolecules

The purpose of this work was to develop a synthesis technique and study the physico-chemical properties of copper carbonate nanoparticles (CC-NPs) stabilized with biopolymers to assess their biocompatibility and toxicity. For the synthesis of CC-NPs, Cu(CH3COO)2 and CuCl2 were used as Cu precursors,...

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Главные авторы:	Blinov, A. V., Блинов, А. В., Nagdalian, A. A., Нагдалян, А. А., Rzhepakovsky, I. V., Ржепаковский, И. В., Rekhman, Z. A., Рехман, З. А., Askerova, A. S., Аскерова, А. С.
Формат:	Статья
Язык:	English
Опубликовано:	Sami Publishing Company 2025
Темы:	Biocompatibility Toxicity CAM assay Trace element
Online-ссылка:	https://dspace.ncfu.ru/handle/123456789/29620
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spelling	ir-123456789-296202025-02-05T11:33:49Z Assessment of biocompatibility and toxicity of basic copper carbonate nanoparticles stabilized with biological macromolecules Blinov, A. V. Блинов, А. В. Nagdalian, A. A. Нагдалян, А. А. Rzhepakovsky, I. V. Ржепаковский, И. В. Rekhman, Z. A. Рехман, З. А. Askerova, A. S. Аскерова, А. С. Biocompatibility Toxicity CAM assay Trace element The purpose of this work was to develop a synthesis technique and study the physico-chemical properties of copper carbonate nanoparticles (CC-NPs) stabilized with biopolymers to assess their biocompatibility and toxicity. For the synthesis of CC-NPs, Cu(CH3COO)2 and CuCl2 were used as Cu precursors, while K₂CO₃, (NH₄)₂CO₃ and (NH₄)₂CO₃ were used as precipitators. The following biopolymers were used as stabilizing agents: chitosan, methylcellulose, hydroxyethyl cellulose and hyaluronic acid. The experimental data showed that Cu(CH3COO)2 is the optimal precursor and (NH4)2CO3 is the optimal precipitator for the production of CC-NPs. The optimal sample consists of spherical aggregates with a diameter of 0.6 to 1.0 µm formed by nanoparticles with a diameter of 30 to 80 nm. This sample has a phase composition of Cu2(OH)2CO3. All considered biopolymers were appropriate for stabilization of CC-NPs, but hyaluronic acid was selected as the optimal stabilizing agent. Interestingly, 10 mg of CC-NPs+HA powder caused 100% mortality of chicken embryos. The structural and surface properties of CC-NPs+HA powder allowed it to be absorbed on the surface of CAM while preserving the implantation site throughout the experiment. It is worth noting that the implantation of the CC-NPs+HA sample was accompanied by a clearly identified degradation of small and large vessels. Thus, the results of CAM assay indicate pronounced toxic changes in CAM under the action of CC-NPs+HA. Surprisingly, despite the fact that Cu is an essential trace element, the developed CC-NPs+HA complex is characterized by low biocompatibility and high toxicity. 2025-02-05T11:32:32Z 2025-02-05T11:32:32Z 2025 Статья Blinov, A., Nagdalian, A., Rzhepakovsky, I., Rekhman, Z., Askerova, A., Agzamov, V., Kayumov, U., Tairov, D., Ibrahimov, S., Sayahov, I. Assessment of biocompatibility and toxicity of basic copper carbonate nanoparticles stabilized with biological macromolecules // Journal of Medicinal and Pharmaceutical Chemistry Research. - 2025. - 7 (8). - pp. 1747-1762. - DOI: 10.48309/jmpcr.2025.484155.1469 https://dspace.ncfu.ru/handle/123456789/29620 en Journal of Medicinal and Pharmaceutical Chemistry Research application/pdf application/pdf Sami Publishing Company
institution	СКФУ
collection	Репозиторий
language	English
topic	Biocompatibility Toxicity CAM assay Trace element
spellingShingle	Biocompatibility Toxicity CAM assay Trace element Blinov, A. V. Блинов, А. В. Nagdalian, A. A. Нагдалян, А. А. Rzhepakovsky, I. V. Ржепаковский, И. В. Rekhman, Z. A. Рехман, З. А. Askerova, A. S. Аскерова, А. С. Assessment of biocompatibility and toxicity of basic copper carbonate nanoparticles stabilized with biological macromolecules
description	The purpose of this work was to develop a synthesis technique and study the physico-chemical properties of copper carbonate nanoparticles (CC-NPs) stabilized with biopolymers to assess their biocompatibility and toxicity. For the synthesis of CC-NPs, Cu(CH3COO)2 and CuCl2 were used as Cu precursors, while K₂CO₃, (NH₄)₂CO₃ and (NH₄)₂CO₃ were used as precipitators. The following biopolymers were used as stabilizing agents: chitosan, methylcellulose, hydroxyethyl cellulose and hyaluronic acid. The experimental data showed that Cu(CH3COO)2 is the optimal precursor and (NH4)2CO3 is the optimal precipitator for the production of CC-NPs. The optimal sample consists of spherical aggregates with a diameter of 0.6 to 1.0 µm formed by nanoparticles with a diameter of 30 to 80 nm. This sample has a phase composition of Cu2(OH)2CO3. All considered biopolymers were appropriate for stabilization of CC-NPs, but hyaluronic acid was selected as the optimal stabilizing agent. Interestingly, 10 mg of CC-NPs+HA powder caused 100% mortality of chicken embryos. The structural and surface properties of CC-NPs+HA powder allowed it to be absorbed on the surface of CAM while preserving the implantation site throughout the experiment. It is worth noting that the implantation of the CC-NPs+HA sample was accompanied by a clearly identified degradation of small and large vessels. Thus, the results of CAM assay indicate pronounced toxic changes in CAM under the action of CC-NPs+HA. Surprisingly, despite the fact that Cu is an essential trace element, the developed CC-NPs+HA complex is characterized by low biocompatibility and high toxicity.
format	Статья
author	Blinov, A. V. Блинов, А. В. Nagdalian, A. A. Нагдалян, А. А. Rzhepakovsky, I. V. Ржепаковский, И. В. Rekhman, Z. A. Рехман, З. А. Askerova, A. S. Аскерова, А. С.
author_facet	Blinov, A. V. Блинов, А. В. Nagdalian, A. A. Нагдалян, А. А. Rzhepakovsky, I. V. Ржепаковский, И. В. Rekhman, Z. A. Рехман, З. А. Askerova, A. S. Аскерова, А. С.
author_sort	Blinov, A. V.
title	Assessment of biocompatibility and toxicity of basic copper carbonate nanoparticles stabilized with biological macromolecules
title_short	Assessment of biocompatibility and toxicity of basic copper carbonate nanoparticles stabilized with biological macromolecules
title_full	Assessment of biocompatibility and toxicity of basic copper carbonate nanoparticles stabilized with biological macromolecules
title_fullStr	Assessment of biocompatibility and toxicity of basic copper carbonate nanoparticles stabilized with biological macromolecules
title_full_unstemmed	Assessment of biocompatibility and toxicity of basic copper carbonate nanoparticles stabilized with biological macromolecules
title_sort	assessment of biocompatibility and toxicity of basic copper carbonate nanoparticles stabilized with biological macromolecules
publisher	Sami Publishing Company
publishDate	2025
url	https://dspace.ncfu.ru/handle/123456789/29620
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Assessment of biocompatibility and toxicity of basic copper carbonate nanoparticles stabilized with biological macromolecules

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