Synthesis, structure, physico-chemical properties and biological activity of copper(II) ketoiminate complexes derived from N-naphthyl- and N-quinolyl-β-aminovinyl ketones

Four novel copper(II) complexes of N-quinolyl or N-naphthyl substituted β-aminovinyl ketones, derivatives of either benzoylacetaldehyde or benzoylacetone were synthesized. Their structures and physico-chemical properties were studied using single-crystal XRD analysis, XANES and EXAFS, IR, EPR, and U...

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Principais autores:	Demidov, O. P., Демидов, О. П.
Formato:	Статья
Idioma:	English
Publicado em:	Elsevier B.V. 2025
Assuntos:	Biological activity β-Ketoiminate copper(II) complexes Crystal structure DFT calculations β-Aminovinyl ketones
Acesso em linha:	https://dspace.ncfu.ru/handle/123456789/29622
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spelling	ir-123456789-296222025-02-05T11:55:58Z Synthesis, structure, physico-chemical properties and biological activity of copper(II) ketoiminate complexes derived from N-naphthyl- and N-quinolyl-β-aminovinyl ketones Demidov, O. P. Демидов, О. П. Biological activity β-Ketoiminate copper(II) complexes Crystal structure DFT calculations β-Aminovinyl ketones Four novel copper(II) complexes of N-quinolyl or N-naphthyl substituted β-aminovinyl ketones, derivatives of either benzoylacetaldehyde or benzoylacetone were synthesized. Their structures and physico-chemical properties were studied using single-crystal XRD analysis, XANES and EXAFS, IR, EPR, and UV–Vis spectroscopy, magnetic measurements, and DFT calculations. All investigated metal chelates have the ML2 composition. The square-planar coordination geometry in the N-naphthyl substituted copper(II) ketoiminate complexes is formed by bidentate NO coordination of the deprotonated β-aminovinyl ketones. Both copper(II) N-quinolyl substituted ketoiminate complexes have square-pyramidal coordination geometry with one of two deprotonated β-aminovinyl ketone ligands coordinated as NNO tridentate. In the copper(II) complex of N-quinolyl substituted β-aminovinyl ketone derived from benzoylacetaldehyde, the remaining coordination sites are occupied with the enamine and quinoline nitrogen atoms of the second ligand. On the other hand, in the copper(II) complex prepared from its β-methyl derivative the second ligand coordinates through the azomethine nitrogen and the enamine ketone oxygen. Antibacterial, antifungal, and protistocidal activity of compounds was tested. The β-methyl substituted N-quinolyl-β-aminovinyl ketone and its copper(II) complex exhibit the most pronounced biological activity. 2025-02-05T11:54:14Z 2025-02-05T11:54:14Z 2025 Статья Uraev, A.I., Milenković, M.R., Vlasenko, V.G., Lyssenko, K.A., Demidov, O.P., Shiryaeva, A.A., Bubnov, M.P., Knyazev, P.A., Garnovskii, D.A., Burlov, A.S., Zubenko, A.A. Synthesis, structure, physico-chemical properties and biological activity of copper(II) ketoiminate complexes derived from N-naphthyl- and N-quinolyl-β-aminovinyl ketones // Inorganica Chimica Acta. - 2025. - 579. - статья № 122560. - DOI: 10.1016/j.ica.2025.122560 https://dspace.ncfu.ru/handle/123456789/29622 en Inorganica Chimica Acta application/pdf application/pdf Elsevier B.V.
institution	СКФУ
collection	Репозиторий
language	English
topic	Biological activity β-Ketoiminate copper(II) complexes Crystal structure DFT calculations β-Aminovinyl ketones
spellingShingle	Biological activity β-Ketoiminate copper(II) complexes Crystal structure DFT calculations β-Aminovinyl ketones Demidov, O. P. Демидов, О. П. Synthesis, structure, physico-chemical properties and biological activity of copper(II) ketoiminate complexes derived from N-naphthyl- and N-quinolyl-β-aminovinyl ketones
description	Four novel copper(II) complexes of N-quinolyl or N-naphthyl substituted β-aminovinyl ketones, derivatives of either benzoylacetaldehyde or benzoylacetone were synthesized. Their structures and physico-chemical properties were studied using single-crystal XRD analysis, XANES and EXAFS, IR, EPR, and UV–Vis spectroscopy, magnetic measurements, and DFT calculations. All investigated metal chelates have the ML2 composition. The square-planar coordination geometry in the N-naphthyl substituted copper(II) ketoiminate complexes is formed by bidentate NO coordination of the deprotonated β-aminovinyl ketones. Both copper(II) N-quinolyl substituted ketoiminate complexes have square-pyramidal coordination geometry with one of two deprotonated β-aminovinyl ketone ligands coordinated as NNO tridentate. In the copper(II) complex of N-quinolyl substituted β-aminovinyl ketone derived from benzoylacetaldehyde, the remaining coordination sites are occupied with the enamine and quinoline nitrogen atoms of the second ligand. On the other hand, in the copper(II) complex prepared from its β-methyl derivative the second ligand coordinates through the azomethine nitrogen and the enamine ketone oxygen. Antibacterial, antifungal, and protistocidal activity of compounds was tested. The β-methyl substituted N-quinolyl-β-aminovinyl ketone and its copper(II) complex exhibit the most pronounced biological activity.
format	Статья
author	Demidov, O. P. Демидов, О. П.
author_facet	Demidov, O. P. Демидов, О. П.
author_sort	Demidov, O. P.
title	Synthesis, structure, physico-chemical properties and biological activity of copper(II) ketoiminate complexes derived from N-naphthyl- and N-quinolyl-β-aminovinyl ketones
title_short	Synthesis, structure, physico-chemical properties and biological activity of copper(II) ketoiminate complexes derived from N-naphthyl- and N-quinolyl-β-aminovinyl ketones
title_full	Synthesis, structure, physico-chemical properties and biological activity of copper(II) ketoiminate complexes derived from N-naphthyl- and N-quinolyl-β-aminovinyl ketones
title_fullStr	Synthesis, structure, physico-chemical properties and biological activity of copper(II) ketoiminate complexes derived from N-naphthyl- and N-quinolyl-β-aminovinyl ketones
title_full_unstemmed	Synthesis, structure, physico-chemical properties and biological activity of copper(II) ketoiminate complexes derived from N-naphthyl- and N-quinolyl-β-aminovinyl ketones
title_sort	synthesis, structure, physico-chemical properties and biological activity of copper(ii) ketoiminate complexes derived from n-naphthyl- and n-quinolyl-β-aminovinyl ketones
publisher	Elsevier B.V.
publishDate	2025
url	https://dspace.ncfu.ru/handle/123456789/29622
work_keys_str_mv	AT demidovop synthesisstructurephysicochemicalpropertiesandbiologicalactivityofcopperiiketoiminatecomplexesderivedfromnnaphthylandnquinolylbaminovinylketones AT demidovop synthesisstructurephysicochemicalpropertiesandbiologicalactivityofcopperiiketoiminatecomplexesderivedfromnnaphthylandnquinolylbaminovinylketones
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Synthesis, structure, physico-chemical properties and biological activity of copper(II) ketoiminate complexes derived from N-naphthyl- and N-quinolyl-β-aminovinyl ketones

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