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Enhancement of stability and activity of zinc carbonate nanoparticles using chitosan, hydroxyethyl cellulose, methyl cellulose and hyaluronic acid for multifaceted applications in medicine

Enhancement of stability and activity of zinc carbonate nanoparticles using chitosan, hydroxyethyl cellulose, methyl cellulose and hyaluronic acid for multifaceted applications in medicine

Currently, biopolymer-based Zn-containing nanoforms are of great interest for medical applications. However, there is lack information on optimal synthesis parameters, reagents and stabilizing agent for production of zinc carbonate nanoparticles (ZnC-NPs). In this work, synthesis of ZnC-NPs was carr...

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Главные авторы: Blinov, A. V., Блинов, А. В., Rekhman, Z. A., Рехман, З. А., Yasnaya, M. A., Ясная, М. А., Gvozdenko, A. A., Гвозденко, А. А., Golik, A. B., Голик, А. Б., Kravtsov, A. A., Кравцов, А. А., Shevchenko, I. M., Шевченко, И. М., Askerova, A. S., Аскерова, А. С., Prasolova, A. V., Прасолова, А. В., Pirogov, M. A., Пирогов, М. А., Piskov, S. I., Писков, С. И., Rzhepakovsky, I. V., Ржепаковский, И. В., Nagdalian, A. A., Нагдалян, А. А.
Формат: Статья
Язык:English
Опубликовано: Elsevier B.V. 2025
Темы:
Biocompatibility
Quantum chemical modelling
CAM assay
Online-ссылка:https://dspace.ncfu.ru/handle/123456789/29628
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spelling ir-123456789-296282025-02-05T12:58:48Z Enhancement of stability and activity of zinc carbonate nanoparticles using chitosan, hydroxyethyl cellulose, methyl cellulose and hyaluronic acid for multifaceted applications in medicine Blinov, A. V. Блинов, А. В. Rekhman, Z. A. Рехман, З. А. Yasnaya, M. A. Ясная, М. А. Gvozdenko, A. A. Гвозденко, А. А. Golik, A. B. Голик, А. Б. Kravtsov, A. A. Кравцов, А. А. Shevchenko, I. M. Шевченко, И. М. Askerova, A. S. Аскерова, А. С. Prasolova, A. V. Прасолова, А. В. Pirogov, M. A. Пирогов, М. А. Piskov, S. I. Писков, С. И. Rzhepakovsky, I. V. Ржепаковский, И. В. Nagdalian, A. A. Нагдалян, А. А. Biocompatibility Quantum chemical modelling CAM assay Currently, biopolymer-based Zn-containing nanoforms are of great interest for medical applications. However, there is lack information on optimal synthesis parameters, reagents and stabilizing agent for production of zinc carbonate nanoparticles (ZnC-NPs). In this work, synthesis of ZnC-NPs was carried out by chemical precipitation with the use of chitosan, hydroxyethyl cellulose, methyl cellulose and hyaluronic acid as stabilizing agents. The optimal precursor (Zn(CH3COO)2) and the optimal precipitator ((NH₄)₂CO₃) were detected. ZnC-NPs had one phase (Zn5(OH)6(CO3)2) with diameter from 35 to 120 nm. Thus, the optimal synthesis parameters were set as stoichiometric ratio of precursor and precipitator and the maximum concentration of biopolymer. It was found that polymers are sorbed on different crystallographic planes of crystallites, which affects the morphology of Zn5(OH)6(CO3). Quantum chemical modelling revealed that all models of interaction are energetically advantageous (∆E > 9788.910 kcal/mol) and preferably occurs through OH group, which was confirmed by FTIR spectroscopy of synthesized samples. Notably, CAM assay and histological evaluation showed that ZnC-NPs stabilized with chitosan (as represent of considered biopolymers) have no toxic effect and are compatible with CAM biological environment, which open a great potential for further studies of ZnC-NPs stabilized with biopolymers for multifaceted applications in medicine. 2025-02-05T12:54:51Z 2025-02-05T12:54:51Z 2025 Статья Blinov, A., Rekhman, Z., Yasnaya, M., Gvozdenko, A., Golik, A., Kravtsov, A., Shevchenko, I., Askerova, A., Prasolova, A., Pirogov, M., Piskov, S., Rzhepakovsky, I., Nagdalian, A. Enhancement of stability and activity of zinc carbonate nanoparticles using chitosan, hydroxyethyl cellulose, methyl cellulose and hyaluronic acid for multifaceted applications in medicine // International Journal of Biological Macromolecules. - 2025. - 298. - статья № 139768. - DOI: 10.1016/j.ijbiomac.2025.139768 https://dspace.ncfu.ru/handle/123456789/29628 en International Journal of Biological Macromolecules application/pdf application/pdf Elsevier B.V.
institution СКФУ
collection Репозиторий
language English
topic Biocompatibility
Quantum chemical modelling
CAM assay
spellingShingle Biocompatibility
Quantum chemical modelling
CAM assay
Blinov, A. V.
Блинов, А. В.
Rekhman, Z. A.
Рехман, З. А.
Yasnaya, M. A.
Ясная, М. А.
Gvozdenko, A. A.
Гвозденко, А. А.
Golik, A. B.
Голик, А. Б.
Kravtsov, A. A.
Кравцов, А. А.
Shevchenko, I. M.
Шевченко, И. М.
Askerova, A. S.
Аскерова, А. С.
Prasolova, A. V.
Прасолова, А. В.
Pirogov, M. A.
Пирогов, М. А.
Piskov, S. I.
Писков, С. И.
Rzhepakovsky, I. V.
Ржепаковский, И. В.
Nagdalian, A. A.
Нагдалян, А. А.
Enhancement of stability and activity of zinc carbonate nanoparticles using chitosan, hydroxyethyl cellulose, methyl cellulose and hyaluronic acid for multifaceted applications in medicine
description Currently, biopolymer-based Zn-containing nanoforms are of great interest for medical applications. However, there is lack information on optimal synthesis parameters, reagents and stabilizing agent for production of zinc carbonate nanoparticles (ZnC-NPs). In this work, synthesis of ZnC-NPs was carried out by chemical precipitation with the use of chitosan, hydroxyethyl cellulose, methyl cellulose and hyaluronic acid as stabilizing agents. The optimal precursor (Zn(CH3COO)2) and the optimal precipitator ((NH₄)₂CO₃) were detected. ZnC-NPs had one phase (Zn5(OH)6(CO3)2) with diameter from 35 to 120 nm. Thus, the optimal synthesis parameters were set as stoichiometric ratio of precursor and precipitator and the maximum concentration of biopolymer. It was found that polymers are sorbed on different crystallographic planes of crystallites, which affects the morphology of Zn5(OH)6(CO3). Quantum chemical modelling revealed that all models of interaction are energetically advantageous (∆E > 9788.910 kcal/mol) and preferably occurs through OH group, which was confirmed by FTIR spectroscopy of synthesized samples. Notably, CAM assay and histological evaluation showed that ZnC-NPs stabilized with chitosan (as represent of considered biopolymers) have no toxic effect and are compatible with CAM biological environment, which open a great potential for further studies of ZnC-NPs stabilized with biopolymers for multifaceted applications in medicine.
format Статья
author Blinov, A. V.
Блинов, А. В.
Rekhman, Z. A.
Рехман, З. А.
Yasnaya, M. A.
Ясная, М. А.
Gvozdenko, A. A.
Гвозденко, А. А.
Golik, A. B.
Голик, А. Б.
Kravtsov, A. A.
Кравцов, А. А.
Shevchenko, I. M.
Шевченко, И. М.
Askerova, A. S.
Аскерова, А. С.
Prasolova, A. V.
Прасолова, А. В.
Pirogov, M. A.
Пирогов, М. А.
Piskov, S. I.
Писков, С. И.
Rzhepakovsky, I. V.
Ржепаковский, И. В.
Nagdalian, A. A.
Нагдалян, А. А.
author_facet Blinov, A. V.
Блинов, А. В.
Rekhman, Z. A.
Рехман, З. А.
Yasnaya, M. A.
Ясная, М. А.
Gvozdenko, A. A.
Гвозденко, А. А.
Golik, A. B.
Голик, А. Б.
Kravtsov, A. A.
Кравцов, А. А.
Shevchenko, I. M.
Шевченко, И. М.
Askerova, A. S.
Аскерова, А. С.
Prasolova, A. V.
Прасолова, А. В.
Pirogov, M. A.
Пирогов, М. А.
Piskov, S. I.
Писков, С. И.
Rzhepakovsky, I. V.
Ржепаковский, И. В.
Nagdalian, A. A.
Нагдалян, А. А.
author_sort Blinov, A. V.
title Enhancement of stability and activity of zinc carbonate nanoparticles using chitosan, hydroxyethyl cellulose, methyl cellulose and hyaluronic acid for multifaceted applications in medicine
title_short Enhancement of stability and activity of zinc carbonate nanoparticles using chitosan, hydroxyethyl cellulose, methyl cellulose and hyaluronic acid for multifaceted applications in medicine
title_full Enhancement of stability and activity of zinc carbonate nanoparticles using chitosan, hydroxyethyl cellulose, methyl cellulose and hyaluronic acid for multifaceted applications in medicine
title_fullStr Enhancement of stability and activity of zinc carbonate nanoparticles using chitosan, hydroxyethyl cellulose, methyl cellulose and hyaluronic acid for multifaceted applications in medicine
title_full_unstemmed Enhancement of stability and activity of zinc carbonate nanoparticles using chitosan, hydroxyethyl cellulose, methyl cellulose and hyaluronic acid for multifaceted applications in medicine
title_sort enhancement of stability and activity of zinc carbonate nanoparticles using chitosan, hydroxyethyl cellulose, methyl cellulose and hyaluronic acid for multifaceted applications in medicine
publisher Elsevier B.V.
publishDate 2025
url https://dspace.ncfu.ru/handle/123456789/29628
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