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An Oxidative SNH Alkylamination of 5(6,7,8)-Nitroquinoline N-Oxides in Aqueous Dioxane Medium

An Oxidative SNH Alkylamination of 5(6,7,8)-Nitroquinoline N-Oxides in Aqueous Dioxane Medium

A novel and efficient method for the synthesis of 2-alkylamino and 2-dialkylamino derivatives of N-oxides of 5-, 6-, 7- and 8-nitroquinolines, which can potentially exhibit biological activity, as containing a pharmacophoric quinoline fragment, is described herein. The reactions of 5(6,7,8)-nitroqui...

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書誌詳細
主要な著者: Larin, A. N., Ларин, А. Н., Avakyan, E. K., Авакян, Е. К., Demidov, O. P., Демидов, О. П., Borovleva, A. A., Боровлева, А. А., Pobedinskaya, D. Y., Побединская, Д. Ю., Ermolenko, A. P., Ермоленко, А. П., Kolosov, S. E., Колосов, С. Е., Borovlev, I. V., Боровлев, И. В.
フォーマット: Статья
言語:English
出版事項: John Wiley and Sons Inc 2025
主題:
Alkylamination
ONSH
C−H activation
Nitroquinoline N-oxides
Nucleophilic substitution of hydrogen
オンライン･アクセス:https://dspace.ncfu.ru/handle/123456789/29634
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要約:A novel and efficient method for the synthesis of 2-alkylamino and 2-dialkylamino derivatives of N-oxides of 5-, 6-, 7- and 8-nitroquinolines, which can potentially exhibit biological activity, as containing a pharmacophoric quinoline fragment, is described herein. The reactions of 5(6,7,8)-nitroquinoline N-oxides with various primary or secondary amines in the presence of potassium ferricyanide at in aqueous dioxane medium afforded the corresponding secondary and tertiary amines in moderate to excellent yields. This reaction is the first example of a Chichibabin reaction leading to the formation of 2-alkylaminoquinoline derivatives at position 2 under mild conditions. A study of the antibacterial activity of some products was carried out.

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