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An Oxidative SNH Alkylamination of 5(6,7,8)-Nitroquinoline N-Oxides in Aqueous Dioxane Medium

An Oxidative SNH Alkylamination of 5(6,7,8)-Nitroquinoline N-Oxides in Aqueous Dioxane Medium

A novel and efficient method for the synthesis of 2-alkylamino and 2-dialkylamino derivatives of N-oxides of 5-, 6-, 7- and 8-nitroquinolines, which can potentially exhibit biological activity, as containing a pharmacophoric quinoline fragment, is described herein. The reactions of 5(6,7,8)-nitroqui...

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Auteurs principaux: Larin, A. N., Ларин, А. Н., Avakyan, E. K., Авакян, Е. К., Demidov, O. P., Демидов, О. П., Borovleva, A. A., Боровлева, А. А., Pobedinskaya, D. Y., Побединская, Д. Ю., Ermolenko, A. P., Ермоленко, А. П., Kolosov, S. E., Колосов, С. Е., Borovlev, I. V., Боровлев, И. В.
Format: Статья
Langue:English
Publié: John Wiley and Sons Inc 2025
Sujets:
Alkylamination
ONSH
C−H activation
Nitroquinoline N-oxides
Nucleophilic substitution of hydrogen
Accès en ligne:https://dspace.ncfu.ru/handle/123456789/29634
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