Convenient synthesis and antiproliferative activity of 2-(Indol-2-yl)-2-arylacetamides

Convenient synthesis and antiproliferative activity of 2-(Indol-2-yl)-2-arylacetamides

There have been a limited number of reports describing the preparation of 2-(indol-2-yl)-2-arylacetamides and those syntheses that have been published suffer from significant drawbacks. In addition, this class of compounds has not been evaluated biologically despite the occurrence of 2-(indol-2-yl)-...

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Bibliografiske detaljer
Главные авторы:	Aksenov, D. A., Аксенов, Д. А., Kuzminov, I. K., Кузьминов, И. К., Arutiunov, N. A., Арутюнов, Н. А., Aleksandrova, E. V., Александрова, Е. В., Aksenov, A. V., Аксенов, А. В.
Format:	Статья
Sprog:	English
Udgivet:	Elsevier Ltd 2025
Fag:	Acetamides Neuroblastoma Antiproliferative activity Indole Sodium borohydride
Online adgang:	https://dspace.ncfu.ru/handle/123456789/29804
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Lignende værker

Nitroalkanes as electrophiles: synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity
af: Aksenov, N. A., и др.
Udgivet: (2020)

Direct conversion of 3-(2-nitroethyl)-1H-indoles into 2-(1H-indol-2-yl)acetonitriles
af: Aksenov, A. V., и др.
Udgivet: (2021)

Reaction of thieno[2,3-b]pyridines with sodium hypochlorite: An unusual and stereoselective one-pot approach to dimeric pyrrolo[2′,3′:4,5]thieno[2,3-b]pyridines
af: Dotsenko, V. V., и др.
Udgivet: (2019)

Novel Two-Step Synthesis of N -Alkylated 2,3-Diaryl-4-quinolones
af: Aksenov, A. V., и др.
Udgivet: (2024)

Preparation of stereodefined 2-(3-Oxoindolin-2-yl)-2-arylacetonitriles via one-pot reaction of indoles with nitroalkenes
af: Aksenov, A. V., и др.
Udgivet: (2019)

A Convenient Way to Quinoxaline Derivatives through the Reaction of 2-(3-Oxoindolin-2-yl)-2-phenylacetonitriles with Benzene-1,2-diamines
af: Aksenov, A. V., и др.
Udgivet: (2022)

Direct reductive coupling of indoles to nitrostyrenes en route to (indol-3-yl)acetamides
af: Aksenov, A. V., и др.
Udgivet: (2018)

Microwave synthesis of 2-[(E)-2-(1H-indol-3-yl)vinyl]hetarenes
af: Aksenov, A. V., и др.
Udgivet: (2018)

Improved method for preparation of 3-(1H-Indol-3-yl)benzofuran-2(3H)-ones
af: Grishin, I. Y., и др.
Udgivet: (2022)

Syntheses of 3-(2-Nitrovinyl)-indoles, Benzo[a]carbazoles, Naphtho[2,1-a]carbazoles, and 1-Hydroxy-β-carbolines Lead to Identification of Antiproliferative Compounds Active under Hypoxia
af: Arutiunov, N. A., и др.
Udgivet: (2024)

Synthesis of (2E,4E)-2-(4-Aryl-1,3-selenazol-2-yl)-5-phenylpenta-2,4-dienenitriles
af: Aksenov, N. A., и др.
Udgivet: (2025)

Unexpected cyclization of 2-(2-aminophenyl)indoles with nitroalkenes to furnish indolo[3,2-: C] quinolines
af: Aksenov, A. V., и др.
Udgivet: (2018)

Synthesis, crystal structure, and dielectric properties of high-entropy solid solutions xNa1/2Bi1/2TiO3 – (1-x)(Ba1/3Sr1/3Ca1/3)TiO3 (x = 0.2, 0.3, 0.4, 0.5, 0.6)
af: Chebyshev, K. A., и др.
Udgivet: (2025)

Introduction of tetrazol-1-yl and 5-methyltetrazol-1-yl substituents in the phenyl ring of dibenzo-18-crown-6
af: Aksenov, N. A., и др.
Udgivet: (2018)

Oxidative Dimerization of (Thiazol-2-yl)acetonitriles with Molecular Iodine: Synthesis and Structure of 2,3-Bis(4-aryl-1,3-thiazol-2-yl)but-2-enedinitriles
af: Dotsenko, V. V., и др.
Udgivet: (2024)

Regioselective Nitration of (2E)-3-Aryl-2-(4-arylthiazol-2-yl)acrylonitriles
af: Dotsenko, V. V., и др.
Udgivet: (2024)

Novel convenient one-pot method for the synthesis of indoloquinolines
af: Aksenov, N. A., и др.
Udgivet: (2019)

Michael addition to 3-(2-nitrovinyl)indoles – route toward aliphatic nitro compounds with heterocyclic substituents
af: Aksenov, N. A., и др.
Udgivet: (2019)

Synthesis of spiro[indole-3,5′-isoxazoles] with anticancer activity via a formal [4 + 1]-spirocyclization of nitroalkenes to indoles
af: Aksenov, A. V., и др.
Udgivet: (2019)

Michael addition to unprotected 3-(2-nitrovinyl)indoles under the conditions of microwave synthesis
af: Aksenov, A. V., и др.
Udgivet: (2018)

Synthesis and Structure of (2E)-3-Aryl(hetaryl)-2-[5-bromo-4-aryl(hetaryl)-1,3-thiazol-2-yl]acrylonitriles
af: Dotsenko, V. V., и др.
Udgivet: (2021)

Synthesis and Regiospecific Bromination of (2E,4E)-5-Aryl-2-(4-arylthiazol-2-yl)penta-2,4-dienenitrile
af: Dotsenko, V. V., и др.
Udgivet: (2021)

Synthesis, structure, and analgesic activity of 4-(5-Cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic acids ethyl esters
af: Dotsenko, V. V., и др.
Udgivet: (2022)

Metal-free ring expansion of indoles with nitroalkenes: A simple, modular approach to 3-substituted 2-quinolones
af: Aksenov, A. V., и др.
Udgivet: (2019)

Synthesis of 11H-indolo[3,2-c]quinolines by SnCl4-catalyzed cyclization of indole-3-carbaldehyde oximes
af: Aksenov, N. A., и др.
Udgivet: (2020)

Substituted N-(thieno[2,3-b]pyridine-3-yl)acetamides: synthesis, reactions, and biological activity
af: Dotsenko, V. V., и др.
Udgivet: (2019)

Oxidation of 2-(5-bromo-3,4-dihydropyrimidin-4-yl)phenols, a new approach to the synthesis of benzofuro[3,2-d]pyrimidines
af: Shcherbakov, S. V., и др.
Udgivet: (2023)

Synthesis of New (2E,4E)-2-Cyano-5-phenylpenta-2,4-dienethioamide Derivatives
af: Aksenov, N. A., и др.
Udgivet: (2025)

Preparation of spiro[indole-3,5′-isoxazoles] via Grignard conjugate addition/spirocyclization sequence
af: Aksenov, A. V., и др.
Udgivet: (2021)

Nitrostyrenes as 1,4-CCNO-dipoles: diastereoselective formal [4+1] cycloaddition of indoles
af: Aksenov, A. V., и др.
Udgivet: (2018)

Synthesis, Structure, and Bromination of 3-(Arylamino)-2-(4-arylthiazol-2-yl)acrylonitriles
af: Dotsenko, V. V., и др.
Udgivet: (2025)

Reactions of 3,4-dihydroisoquinolines and dihydrothieno[3,2-c]pyridines with benzyne
af: Aksenov, A. V., и др.
Udgivet: (2018)

A facile synthesis of 1-oxo-pyrrolo[2,1-a]isoquinolines
af: Aksenov, A. V., и др.
Udgivet: (2018)

Reaction of benzyne with 1,2,3,4-tetrahydroisoquinolines as an access to 1H-3-benzazepines
af: Aksenov, A. V., и др.
Udgivet: (2018)

A novel multi-component approach to the synthesis of pyrrolo[2,1-a] isoquinoline derivatives
af: Aksenov, A. V., и др.
Udgivet: (2018)

One-Pot Synthesis of Polynuclear Indole Derivatives by Friedel-Crafts Alkylation of γ-Hydroxybutyrolactams
af: Abaev, V. T., и др.
Udgivet: (2023)

Oxidative Cyclization of 4-(2-Aminophenyl)-4-oxo-2-phenylbutanenitriles into 2-(3-Oxoindolin-2-ylidene)acetonitriles
af: Aksenov, N. A., и др.
Udgivet: (2022)

Synthesis of 2-carboxyaniline-substituted maleimides from 2'-nitrochalcones
af: Aksenov, N. A., и др.
Udgivet: (2023)

Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic acids and evaluation of cytotoxic activity of the products
af: Aksenov, D. A., и др.
Udgivet: (2022)

One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-Ylidene)-2-Arylacetonitriles
af: Aksenov, N. A., и др.
Udgivet: (2022)