Anion and Substituents Effect on Spectral-Kinetic and Biological Characteristics of Spiropyran Salts

Spiropyran salts containing a cationic vinyl-3H-indolium moiety are characterized by NIR absorption and fluorescence of their merocyanine forms. This feature makes them promising fluorescent probes and markers for bioimaging. The article focuses on the synthesis and study of the spectral, kinetic an...

תיאור מלא

שמור ב:

מידע ביבליוגרפי
Главные авторы:	Demidov, O. P., Демидов, О. П.
פורמט:	Статья
שפה:	English
יצא לאור:	John Wiley and Sons Inc 2025
נושאים:	Biofilms Spiropyran Biosensors Bioimaging NIR-fluorescence
גישה מקוונת:	https://dspace.ncfu.ru/handle/123456789/29838
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!

id	ir-123456789-29838
record_format	dspace
spelling	ir-123456789-298382025-03-03T10:59:04Z Anion and Substituents Effect on Spectral-Kinetic and Biological Characteristics of Spiropyran Salts Demidov, O. P. Демидов, О. П. Biofilms Spiropyran Biosensors Bioimaging NIR-fluorescence Spiropyran salts containing a cationic vinyl-3H-indolium moiety are characterized by NIR absorption and fluorescence of their merocyanine forms. This feature makes them promising fluorescent probes and markers for bioimaging. The article focuses on the synthesis and study of the spectral, kinetic and toxic characteristics of such compounds with respect to various substituents in different moieties and the type of anion. A detailed analysis of the acquired data made it possible to draw some important conclusions regarding the influence of structural factors, which will be very useful for the further rational design of such derivatives. In particular, it was shown that the counterion has minimal effect on the spectral and kinetic characteristics of the dyes but dramatically affects the toxicity of the compounds. Following selection of the most appropriate compounds, bioimaging experiments were carried out to visualize planktonic bacteria and bacterial biofilms of E. coli and A. calcoaceticus. The ability to visualize biofilms is critical for the diagnosis of chronic diseases. By the results of molecular docking a theoretical interaction pattern between spiropyran molecules and DNA was proposed. 2025-03-03T10:57:56Z 2025-03-03T10:57:56Z 2025 Статья Pugachev A.D., Kozlenko A.S., Sazykina M.A., Sazykin I.S., Rostovtseva I.A., Makarova N.I., Borodkin G.S., Tkachev V.V., Utenyshev A.N., Demidov O.P., Matukhno A.E., Ponyatovskaya A.M., Azhogina T.N., Karchava S.K., Klimova M.V., Aldoshin S.M., Metelitsa A.V., Ozhogin I.V. Anion and Substituents Effect on Spectral-Kinetic and Biological Characteristics of Spiropyran Salts // ChemBioChem. - 2025. - 26 (3). - art. no. e202400800. - DOI: 10.1002/cbic.202400800 https://dspace.ncfu.ru/handle/123456789/29838 en ChemBioChem application/pdf application/pdf John Wiley and Sons Inc
institution	СКФУ
collection	Репозиторий
language	English
topic	Biofilms Spiropyran Biosensors Bioimaging NIR-fluorescence
spellingShingle	Biofilms Spiropyran Biosensors Bioimaging NIR-fluorescence Demidov, O. P. Демидов, О. П. Anion and Substituents Effect on Spectral-Kinetic and Biological Characteristics of Spiropyran Salts
description	Spiropyran salts containing a cationic vinyl-3H-indolium moiety are characterized by NIR absorption and fluorescence of their merocyanine forms. This feature makes them promising fluorescent probes and markers for bioimaging. The article focuses on the synthesis and study of the spectral, kinetic and toxic characteristics of such compounds with respect to various substituents in different moieties and the type of anion. A detailed analysis of the acquired data made it possible to draw some important conclusions regarding the influence of structural factors, which will be very useful for the further rational design of such derivatives. In particular, it was shown that the counterion has minimal effect on the spectral and kinetic characteristics of the dyes but dramatically affects the toxicity of the compounds. Following selection of the most appropriate compounds, bioimaging experiments were carried out to visualize planktonic bacteria and bacterial biofilms of E. coli and A. calcoaceticus. The ability to visualize biofilms is critical for the diagnosis of chronic diseases. By the results of molecular docking a theoretical interaction pattern between spiropyran molecules and DNA was proposed.
format	Статья
author	Demidov, O. P. Демидов, О. П.
author_facet	Demidov, O. P. Демидов, О. П.
author_sort	Demidov, O. P.
title	Anion and Substituents Effect on Spectral-Kinetic and Biological Characteristics of Spiropyran Salts
title_short	Anion and Substituents Effect on Spectral-Kinetic and Biological Characteristics of Spiropyran Salts
title_full	Anion and Substituents Effect on Spectral-Kinetic and Biological Characteristics of Spiropyran Salts
title_fullStr	Anion and Substituents Effect on Spectral-Kinetic and Biological Characteristics of Spiropyran Salts
title_full_unstemmed	Anion and Substituents Effect on Spectral-Kinetic and Biological Characteristics of Spiropyran Salts
title_sort	anion and substituents effect on spectral-kinetic and biological characteristics of spiropyran salts
publisher	John Wiley and Sons Inc
publishDate	2025
url	https://dspace.ncfu.ru/handle/123456789/29838
work_keys_str_mv	AT demidovop anionandsubstituentseffectonspectralkineticandbiologicalcharacteristicsofspiropyransalts AT demidovop anionandsubstituentseffectonspectralkineticandbiologicalcharacteristicsofspiropyransalts
_version_	1842245407697010688

Anion and Substituents Effect on Spectral-Kinetic and Biological Characteristics of Spiropyran Salts

פריטים דומים