One-pot synthesis of 4-methyl-2-alkyl quinazoline-N-oxides by cascade acetamidation–acylation of simple electron-rich arenes with primary nitroalkanes

A one-pot, two-stage reaction sequence leading to 2,4-dialkylquinazoline-3-oxide derivatives has been developed. It begins with the in situ formation of anilides by the Beckmann-type acetamidation of simple, bearing electron-donating groups arenes with primary nitroalkanes in polyphosphoric acid. Su...

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Главные авторы:	Grishin, I. Y., Гришин, И. Ю., Aksenov, D. A., Аксенов, Д. А., Aksenov, N. A., Аксенов, Н. А., Grishin, Y. I., Гришин, Ю. И., Leontiev, A. V., Леонтьев, А. В., Aksenov, A. V., Аксенов, А. В.
Formato:	Статья
Idioma:	English
Publicado:	Elsevier Ltd 2025
Темы:	Acylamidation Quinazolines Aliphatic nitroalkanes Beckmann rearrangement Cascade transformations Polyphosphoric acid Heterocyclic compounds
Acceso en liña:	https://dspace.ncfu.ru/handle/123456789/30390
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https://dspace.ncfu.ru/handle/123456789/30390

One-pot synthesis of 4-methyl-2-alkyl quinazoline-N-oxides by cascade acetamidation–acylation of simple electron-rich arenes with primary nitroalkanes

Internet

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