Ferrous Ascorbate Nicotinate: A New Form of the Essential Trace Element Fe against Iron Deficiency Anemia

In this work, a triple chelated mixed ligand complex of Fe with ascorbic and nicotinic acids was synthesized for the first time. The synthesis method was optimized and the optical properties as well as the stability of the resulting complex were studied. It was found that variation of technological...

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Autores principales:	Blinov, A. V., Блинов, А. В., Samovolov, A. V., Самоволов, А. В., Rekhman, Z. A., Рехман, З. А., Kastarnova, E. S., Кастарнова, Е. С., Golik, A. B., Голик, А. Б., Serov, A. V., Серов, А. В., Rusev, N. A., Русев, Н. А., Bocharov, N. M., Бочаров, Н. М., Nagdalian, A. A., Нагдалян, А. А.
Formato:	Статья
Lenguaje:	English
Publicado:	Sami Publishing Company 2025
Materias:	Bioavailability Dairy products Chelate complex Iron Milk Vitamins
Acceso en línea:	https://dspace.ncfu.ru/handle/123456789/30518
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spelling	ir-123456789-305182025-06-18T11:51:07Z Ferrous Ascorbate Nicotinate: A New Form of the Essential Trace Element Fe against Iron Deficiency Anemia Blinov, A. V. Блинов, А. В. Samovolov, A. V. Самоволов, А. В. Rekhman, Z. A. Рехман, З. А. Kastarnova, E. S. Кастарнова, Е. С. Golik, A. B. Голик, А. Б. Serov, A. V. Серов, А. В. Rusev, N. A. Русев, Н. А. Bocharov, N. M. Бочаров, Н. М. Nagdalian, A. A. Нагдалян, А. А. Bioavailability Dairy products Chelate complex Iron Milk Vitamins In this work, a triple chelated mixed ligand complex of Fe with ascorbic and nicotinic acids was synthesized for the first time. The synthesis method was optimized and the optical properties as well as the stability of the resulting complex were studied. It was found that variation of technological parameters has no practically effect on physico-chemical properties of the complex, which is important during heat treatment for fortification of milk and dairy products. The optimal model of the coordination of Fe atom with ascorbic and nicotinic acids was determined using quantum chemical modelling. The data were confirmed by FTIR spectroscopy. The physico-chemical and sensory properties of fermented milk product fortified with developed complex were investigated. It is important to note that the complex introduction did not significantly affect the studied parameters. In vivo tests in white rats model revealed that the complex has no pathological effects in blood parameters. At the same time, a dose-dependent increase in Fe concentration in rat’s blood was detected with an increase in the dose of the complex. Finally, workload test on white rats showed an increase in endurance with an increase in the complex concentration. This fact is presumably related to the functional properties of Fe in red blood cells to transport oxygen. 2025-06-18T11:28:41Z 2025-06-18T11:28:41Z 2025 Статья Blinov A., Samovolov A., Rekhman Z., Kastarnova E., Golik A., Serov A.M., Rusev N., Bocharov N., Nagdalian A. Ferrous Ascorbate Nicotinate: A New Form of the Essential Trace Element Fe against Iron Deficiency Anemia // Journal of Applied Organometallic Chemistry. - 2025. - 5 (2). - pp. 168 - 184. - DOI: 10.48309/jaoc.2025.508969.1272 https://dspace.ncfu.ru/handle/123456789/30518 en Journal of Applied Organometallic Chemistry application/pdf Sami Publishing Company
institution	СКФУ
collection	Репозиторий
language	English
topic	Bioavailability Dairy products Chelate complex Iron Milk Vitamins
spellingShingle	Bioavailability Dairy products Chelate complex Iron Milk Vitamins Blinov, A. V. Блинов, А. В. Samovolov, A. V. Самоволов, А. В. Rekhman, Z. A. Рехман, З. А. Kastarnova, E. S. Кастарнова, Е. С. Golik, A. B. Голик, А. Б. Serov, A. V. Серов, А. В. Rusev, N. A. Русев, Н. А. Bocharov, N. M. Бочаров, Н. М. Nagdalian, A. A. Нагдалян, А. А. Ferrous Ascorbate Nicotinate: A New Form of the Essential Trace Element Fe against Iron Deficiency Anemia
description	In this work, a triple chelated mixed ligand complex of Fe with ascorbic and nicotinic acids was synthesized for the first time. The synthesis method was optimized and the optical properties as well as the stability of the resulting complex were studied. It was found that variation of technological parameters has no practically effect on physico-chemical properties of the complex, which is important during heat treatment for fortification of milk and dairy products. The optimal model of the coordination of Fe atom with ascorbic and nicotinic acids was determined using quantum chemical modelling. The data were confirmed by FTIR spectroscopy. The physico-chemical and sensory properties of fermented milk product fortified with developed complex were investigated. It is important to note that the complex introduction did not significantly affect the studied parameters. In vivo tests in white rats model revealed that the complex has no pathological effects in blood parameters. At the same time, a dose-dependent increase in Fe concentration in rat’s blood was detected with an increase in the dose of the complex. Finally, workload test on white rats showed an increase in endurance with an increase in the complex concentration. This fact is presumably related to the functional properties of Fe in red blood cells to transport oxygen.
format	Статья
author	Blinov, A. V. Блинов, А. В. Samovolov, A. V. Самоволов, А. В. Rekhman, Z. A. Рехман, З. А. Kastarnova, E. S. Кастарнова, Е. С. Golik, A. B. Голик, А. Б. Serov, A. V. Серов, А. В. Rusev, N. A. Русев, Н. А. Bocharov, N. M. Бочаров, Н. М. Nagdalian, A. A. Нагдалян, А. А.
author_facet	Blinov, A. V. Блинов, А. В. Samovolov, A. V. Самоволов, А. В. Rekhman, Z. A. Рехман, З. А. Kastarnova, E. S. Кастарнова, Е. С. Golik, A. B. Голик, А. Б. Serov, A. V. Серов, А. В. Rusev, N. A. Русев, Н. А. Bocharov, N. M. Бочаров, Н. М. Nagdalian, A. A. Нагдалян, А. А.
author_sort	Blinov, A. V.
title	Ferrous Ascorbate Nicotinate: A New Form of the Essential Trace Element Fe against Iron Deficiency Anemia
title_short	Ferrous Ascorbate Nicotinate: A New Form of the Essential Trace Element Fe against Iron Deficiency Anemia
title_full	Ferrous Ascorbate Nicotinate: A New Form of the Essential Trace Element Fe against Iron Deficiency Anemia
title_fullStr	Ferrous Ascorbate Nicotinate: A New Form of the Essential Trace Element Fe against Iron Deficiency Anemia
title_full_unstemmed	Ferrous Ascorbate Nicotinate: A New Form of the Essential Trace Element Fe against Iron Deficiency Anemia
title_sort	ferrous ascorbate nicotinate: a new form of the essential trace element fe against iron deficiency anemia
publisher	Sami Publishing Company
publishDate	2025
url	https://dspace.ncfu.ru/handle/123456789/30518
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Ferrous Ascorbate Nicotinate: A New Form of the Essential Trace Element Fe against Iron Deficiency Anemia

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