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Ferrous Ascorbate Nicotinate: A New Form of the Essential Trace Element Fe against Iron Deficiency Anemia

Ferrous Ascorbate Nicotinate: A New Form of the Essential Trace Element Fe against Iron Deficiency Anemia

In this work, a triple chelated mixed ligand complex of Fe with ascorbic and nicotinic acids was synthesized for the first time. The synthesis method was optimized and the optical properties as well as the stability of the resulting complex were studied. It was found that variation of technological...

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मुख्य लेखकों: Blinov, A. V., Блинов, А. В., Samovolov, A. V., Самоволов, А. В., Rekhman, Z. A., Рехман, З. А., Kastarnova, E. S., Кастарнова, Е. С., Golik, A. B., Голик, А. Б., Serov, A. V., Серов, А. В., Rusev, N. A., Русев, Н. А., Bocharov, N. M., Бочаров, Н. М., Nagdalian, A. A., Нагдалян, А. А.
स्वरूप: Статья
भाषा:English
प्रकाशित: Sami Publishing Company 2025
विषय:
Bioavailability
Dairy products
Chelate complex
Iron
Milk
Vitamins
ऑनलाइन पहुंच:https://dspace.ncfu.ru/handle/123456789/30518
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spelling ir-123456789-305182025-06-18T11:51:07Z Ferrous Ascorbate Nicotinate: A New Form of the Essential Trace Element Fe against Iron Deficiency Anemia Blinov, A. V. Блинов, А. В. Samovolov, A. V. Самоволов, А. В. Rekhman, Z. A. Рехман, З. А. Kastarnova, E. S. Кастарнова, Е. С. Golik, A. B. Голик, А. Б. Serov, A. V. Серов, А. В. Rusev, N. A. Русев, Н. А. Bocharov, N. M. Бочаров, Н. М. Nagdalian, A. A. Нагдалян, А. А. Bioavailability Dairy products Chelate complex Iron Milk Vitamins In this work, a triple chelated mixed ligand complex of Fe with ascorbic and nicotinic acids was synthesized for the first time. The synthesis method was optimized and the optical properties as well as the stability of the resulting complex were studied. It was found that variation of technological parameters has no practically effect on physico-chemical properties of the complex, which is important during heat treatment for fortification of milk and dairy products. The optimal model of the coordination of Fe atom with ascorbic and nicotinic acids was determined using quantum chemical modelling. The data were confirmed by FTIR spectroscopy. The physico-chemical and sensory properties of fermented milk product fortified with developed complex were investigated. It is important to note that the complex introduction did not significantly affect the studied parameters. In vivo tests in white rats model revealed that the complex has no pathological effects in blood parameters. At the same time, a dose-dependent increase in Fe concentration in rat’s blood was detected with an increase in the dose of the complex. Finally, workload test on white rats showed an increase in endurance with an increase in the complex concentration. This fact is presumably related to the functional properties of Fe in red blood cells to transport oxygen. 2025-06-18T11:28:41Z 2025-06-18T11:28:41Z 2025 Статья Blinov A., Samovolov A., Rekhman Z., Kastarnova E., Golik A., Serov A.M., Rusev N., Bocharov N., Nagdalian A. Ferrous Ascorbate Nicotinate: A New Form of the Essential Trace Element Fe against Iron Deficiency Anemia // Journal of Applied Organometallic Chemistry. - 2025. - 5 (2). - pp. 168 - 184. - DOI: 10.48309/jaoc.2025.508969.1272 https://dspace.ncfu.ru/handle/123456789/30518 en Journal of Applied Organometallic Chemistry application/pdf Sami Publishing Company
institution СКФУ
collection Репозиторий
language English
topic Bioavailability
Dairy products
Chelate complex
Iron
Milk
Vitamins
spellingShingle Bioavailability
Dairy products
Chelate complex
Iron
Milk
Vitamins
Blinov, A. V.
Блинов, А. В.
Samovolov, A. V.
Самоволов, А. В.
Rekhman, Z. A.
Рехман, З. А.
Kastarnova, E. S.
Кастарнова, Е. С.
Golik, A. B.
Голик, А. Б.
Serov, A. V.
Серов, А. В.
Rusev, N. A.
Русев, Н. А.
Bocharov, N. M.
Бочаров, Н. М.
Nagdalian, A. A.
Нагдалян, А. А.
Ferrous Ascorbate Nicotinate: A New Form of the Essential Trace Element Fe against Iron Deficiency Anemia
description In this work, a triple chelated mixed ligand complex of Fe with ascorbic and nicotinic acids was synthesized for the first time. The synthesis method was optimized and the optical properties as well as the stability of the resulting complex were studied. It was found that variation of technological parameters has no practically effect on physico-chemical properties of the complex, which is important during heat treatment for fortification of milk and dairy products. The optimal model of the coordination of Fe atom with ascorbic and nicotinic acids was determined using quantum chemical modelling. The data were confirmed by FTIR spectroscopy. The physico-chemical and sensory properties of fermented milk product fortified with developed complex were investigated. It is important to note that the complex introduction did not significantly affect the studied parameters. In vivo tests in white rats model revealed that the complex has no pathological effects in blood parameters. At the same time, a dose-dependent increase in Fe concentration in rat’s blood was detected with an increase in the dose of the complex. Finally, workload test on white rats showed an increase in endurance with an increase in the complex concentration. This fact is presumably related to the functional properties of Fe in red blood cells to transport oxygen.
format Статья
author Blinov, A. V.
Блинов, А. В.
Samovolov, A. V.
Самоволов, А. В.
Rekhman, Z. A.
Рехман, З. А.
Kastarnova, E. S.
Кастарнова, Е. С.
Golik, A. B.
Голик, А. Б.
Serov, A. V.
Серов, А. В.
Rusev, N. A.
Русев, Н. А.
Bocharov, N. M.
Бочаров, Н. М.
Nagdalian, A. A.
Нагдалян, А. А.
author_facet Blinov, A. V.
Блинов, А. В.
Samovolov, A. V.
Самоволов, А. В.
Rekhman, Z. A.
Рехман, З. А.
Kastarnova, E. S.
Кастарнова, Е. С.
Golik, A. B.
Голик, А. Б.
Serov, A. V.
Серов, А. В.
Rusev, N. A.
Русев, Н. А.
Bocharov, N. M.
Бочаров, Н. М.
Nagdalian, A. A.
Нагдалян, А. А.
author_sort Blinov, A. V.
title Ferrous Ascorbate Nicotinate: A New Form of the Essential Trace Element Fe against Iron Deficiency Anemia
title_short Ferrous Ascorbate Nicotinate: A New Form of the Essential Trace Element Fe against Iron Deficiency Anemia
title_full Ferrous Ascorbate Nicotinate: A New Form of the Essential Trace Element Fe against Iron Deficiency Anemia
title_fullStr Ferrous Ascorbate Nicotinate: A New Form of the Essential Trace Element Fe against Iron Deficiency Anemia
title_full_unstemmed Ferrous Ascorbate Nicotinate: A New Form of the Essential Trace Element Fe against Iron Deficiency Anemia
title_sort ferrous ascorbate nicotinate: a new form of the essential trace element fe against iron deficiency anemia
publisher Sami Publishing Company
publishDate 2025
url https://dspace.ncfu.ru/handle/123456789/30518
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