Synthesis of 2,2-Dimethyl-2,3-dihydropyrido[3′,2′:4,5]-thieno[3,2-d]pyrimidin-4(1H)-ones by Reaction of 3-Aminothieno[2,3-b]pyridine-2-carboxamides with Acetone

The reaction of 3-aminothieno[2,3-b]pyridin-2-carboxamides with acetone in the presence of catalytic amounts of TsOH under reflux afforded a series of new 2,2-dimethyl-2,3-dihydropyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(1H)-ones in 88–95% yields. Possible protein targets for the new compounds were...

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Главные авторы:	Dotsenko, V. V., Доценко, В. В., Aksenov, N. A., Аксенов, Н. А., Aksenova, I. V., Аксенова, И. В.
Format:	Статья
Jezik:	English
Izdano:	Pleiades Publishing 2025
Teme:	2,4-D herbicide antidotes Thorpe–Ziegler cyclization Pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines Thieno[2,3-b]pyridines
Online dostop:	https://dspace.ncfu.ru/handle/123456789/30521
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spelling	ir-123456789-305212025-06-18T12:45:42Z Synthesis of 2,2-Dimethyl-2,3-dihydropyrido[3′,2′:4,5]-thieno[3,2-d]pyrimidin-4(1H)-ones by Reaction of 3-Aminothieno[2,3-b]pyridine-2-carboxamides with Acetone Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. 2,4-D herbicide antidotes Thorpe–Ziegler cyclization Pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines Thieno[2,3-b]pyridines The reaction of 3-aminothieno[2,3-b]pyridin-2-carboxamides with acetone in the presence of catalytic amounts of TsOH under reflux afforded a series of new 2,2-dimethyl-2,3-dihydropyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(1H)-ones in 88–95% yields. Possible protein targets for the new compounds were identified by molecular docking studies. 2,2-Dimethyl-3-(2-methylphenyl)-9-(4-methoxyphenyl)-7-phenyl-2,3-dihydropyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(1H)-one exhibits antidote effect against 2,4-dichlorophenoxyacetic acid in a laboratory experiment. 2025-06-18T12:42:07Z 2025-06-18T12:42:07Z 2025 Статья Dotsenko V.V., Rudenko S.V., Lukina D.Y., Smirnova A.K., Krivokolysko S.G., Temerdashev A.Z., Harutyunyan A.S., Paronikyan E.G., Aksenov N.A., Aksenova I.V. Synthesis of 2,2-Dimethyl-2,3-dihydropyrido[3′,2′:4,5]-thieno[3,2-d]pyrimidin-4(1H)-ones by Reaction of 3-Aminothieno[2,3-b]pyridine-2-carboxamides with Acetone // Russian Journal of General Chemistry. - 2025. - 95 (5). - pp. 1236 - 1247. - DOI: 10.1134/S1070363225601954 https://dspace.ncfu.ru/handle/123456789/30521 en Russian Journal of General Chemistry application/pdf application/pdf Pleiades Publishing
institution	СКФУ
collection	Репозиторий
language	English
topic	2,4-D herbicide antidotes Thorpe–Ziegler cyclization Pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines Thieno[2,3-b]pyridines
spellingShingle	2,4-D herbicide antidotes Thorpe–Ziegler cyclization Pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines Thieno[2,3-b]pyridines Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. Synthesis of 2,2-Dimethyl-2,3-dihydropyrido[3′,2′:4,5]-thieno[3,2-d]pyrimidin-4(1H)-ones by Reaction of 3-Aminothieno[2,3-b]pyridine-2-carboxamides with Acetone
description	The reaction of 3-aminothieno[2,3-b]pyridin-2-carboxamides with acetone in the presence of catalytic amounts of TsOH under reflux afforded a series of new 2,2-dimethyl-2,3-dihydropyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(1H)-ones in 88–95% yields. Possible protein targets for the new compounds were identified by molecular docking studies. 2,2-Dimethyl-3-(2-methylphenyl)-9-(4-methoxyphenyl)-7-phenyl-2,3-dihydropyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(1H)-one exhibits antidote effect against 2,4-dichlorophenoxyacetic acid in a laboratory experiment.
format	Статья
author	Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В.
author_facet	Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В.
author_sort	Dotsenko, V. V.
title	Synthesis of 2,2-Dimethyl-2,3-dihydropyrido[3′,2′:4,5]-thieno[3,2-d]pyrimidin-4(1H)-ones by Reaction of 3-Aminothieno[2,3-b]pyridine-2-carboxamides with Acetone
title_short	Synthesis of 2,2-Dimethyl-2,3-dihydropyrido[3′,2′:4,5]-thieno[3,2-d]pyrimidin-4(1H)-ones by Reaction of 3-Aminothieno[2,3-b]pyridine-2-carboxamides with Acetone
title_full	Synthesis of 2,2-Dimethyl-2,3-dihydropyrido[3′,2′:4,5]-thieno[3,2-d]pyrimidin-4(1H)-ones by Reaction of 3-Aminothieno[2,3-b]pyridine-2-carboxamides with Acetone
title_fullStr	Synthesis of 2,2-Dimethyl-2,3-dihydropyrido[3′,2′:4,5]-thieno[3,2-d]pyrimidin-4(1H)-ones by Reaction of 3-Aminothieno[2,3-b]pyridine-2-carboxamides with Acetone
title_full_unstemmed	Synthesis of 2,2-Dimethyl-2,3-dihydropyrido[3′,2′:4,5]-thieno[3,2-d]pyrimidin-4(1H)-ones by Reaction of 3-Aminothieno[2,3-b]pyridine-2-carboxamides with Acetone
title_sort	synthesis of 2,2-dimethyl-2,3-dihydropyrido[3′,2′:4,5]-thieno[3,2-d]pyrimidin-4(1h)-ones by reaction of 3-aminothieno[2,3-b]pyridine-2-carboxamides with acetone
publisher	Pleiades Publishing
publishDate	2025
url	https://dspace.ncfu.ru/handle/123456789/30521
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Synthesis of 2,2-Dimethyl-2,3-dihydropyrido[3′,2′:4,5]-thieno[3,2-d]pyrimidin-4(1H)-ones by Reaction of 3-Aminothieno[2,3-b]pyridine-2-carboxamides with Acetone

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