SYNTHESIS OF NANOSIZED ZINC PHOSPHATE STABILIZED WITH BIOLOGICALLY ACTIVE SUBSTANCES

The article presents the results of a study of the interaction of zinc phosphate with biologically active substances using the method of quantum chemical modeling, which obtained models of molecules of biologically active substances (essential amino acids), as well as molecular systems Zn<inf>...

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Главные авторы:	Blinova, A. A., Блинова, А. А., Rekhman, Z. A., Рехман, З. А., Blinov, A. V., Блинов, А. В., Lapin, V. A., Лапин, В. А., Pirogov, M. A., Пирогов, М. А.
Формат:	Статья
Язык:	English
Опубликовано:	Bauman Press 2025
Темы:	Chemical rigidity Zinc phosphate nanoparticles Elemental analysis Essential amino acids Lysine Quantum chemical modeling Scanning electron microscopy X-ray phase analysis
Online-ссылка:	https://dspace.ncfu.ru/handle/123456789/31847
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record_format	dspace
spelling	ir-123456789-318472025-08-12T12:45:20Z SYNTHESIS OF NANOSIZED ZINC PHOSPHATE STABILIZED WITH BIOLOGICALLY ACTIVE SUBSTANCES СИНТЕЗ НАНОРАЗМЕРНОГО ФОСФАТА ЦИНКА, СТАБИЛИЗИРОВАННОГО БИОЛОГИЧЕСКИ АКТИВНЫМИ ВЕЩЕСТВАМИ Blinova, A. A. Блинова, А. А. Rekhman, Z. A. Рехман, З. А. Blinov, A. V. Блинов, А. В. Lapin, V. A. Лапин, В. А. Pirogov, M. A. Пирогов, М. А. Chemical rigidity Zinc phosphate nanoparticles Elemental analysis Essential amino acids Lysine Quantum chemical modeling Scanning electron microscopy X-ray phase analysis The article presents the results of a study of the interaction of zinc phosphate with biologically active substances using the method of quantum chemical modeling, which obtained models of molecules of biologically active substances (essential amino acids), as well as molecular systems Zn<inf>3</inf>(PO<inf>4</inf>)<inf>2</inf>–an essential amino acid, in which the interaction of zinc phosphate with an amino acid occurred through an oxygen atom attached to the phosphorus atom in zinc phosphate, and the ionized amino group of the amino acid. As a result of quantum chemical modeling, it is established that the molecular system Zn<inf>3</inf>(PO<inf>4</inf>)<inf>2</inf>, an essential amino acid, is energetically advantageous and chemically stable. The optimal configuration with the largest total energy difference (73.646 kcal/mol) and chemical rigidity (0.144 eV) is the Zn<inf>3</inf>(PO<inf>4</inf>)<inf>2</inf>–lysine molecular system, in which the interaction occurs through the ionized H-amino group of lysine. The results of the analysis of the microstructure of zinc phosphate nanoparticles stabilized with L-lysine show that the surface of the samples consists of large aggregates with diameters of 6–17 Pn, which are small spherical particles with dimensions of 100–150 nm. The results of the analysis of the elemental composition allowed us to establish the presence of elements such as zinc and phosphorus in the structure. The phase composition of the samples is studied, as a result, it is determined that the sample of zinc phosphate nanoparticles stabilized with L-lysine has orthorhombic syngony with the space group P nma. The samples were examined by IR spectroscopy, which revealed that the amino acid interaction occurs when phosphate binds through amino groups in the amino acid molecule. 2025-08-12T12:42:35Z 2025-08-12T12:42:35Z 2025 Статья Blinova, A. A., Rekhman, Z. A., Kastarnova, E. S., Blinov, A. V., Lapin, V. A., Pirogov, M. A. SYNTHESIS OF NANOSIZED ZINC PHOSPHATE STABILIZED WITH BIOLOGICALLY ACTIVE SUBSTANCES // Herald of the Bauman Moscow State Technical University Series Natural Sciences. - 2025. - 1 (118). - pp. 119 - 136. https://dspace.ncfu.ru/handle/123456789/31847 en Herald of the Bauman Moscow State Technical University, Series Natural Sciences application/pdf Bauman Press
institution	СКФУ
collection	Репозиторий
language	English
topic	Chemical rigidity Zinc phosphate nanoparticles Elemental analysis Essential amino acids Lysine Quantum chemical modeling Scanning electron microscopy X-ray phase analysis
spellingShingle	Chemical rigidity Zinc phosphate nanoparticles Elemental analysis Essential amino acids Lysine Quantum chemical modeling Scanning electron microscopy X-ray phase analysis Blinova, A. A. Блинова, А. А. Rekhman, Z. A. Рехман, З. А. Blinov, A. V. Блинов, А. В. Lapin, V. A. Лапин, В. А. Pirogov, M. A. Пирогов, М. А. SYNTHESIS OF NANOSIZED ZINC PHOSPHATE STABILIZED WITH BIOLOGICALLY ACTIVE SUBSTANCES
description	The article presents the results of a study of the interaction of zinc phosphate with biologically active substances using the method of quantum chemical modeling, which obtained models of molecules of biologically active substances (essential amino acids), as well as molecular systems Zn<inf>3</inf>(PO<inf>4</inf>)<inf>2</inf>–an essential amino acid, in which the interaction of zinc phosphate with an amino acid occurred through an oxygen atom attached to the phosphorus atom in zinc phosphate, and the ionized amino group of the amino acid. As a result of quantum chemical modeling, it is established that the molecular system Zn<inf>3</inf>(PO<inf>4</inf>)<inf>2</inf>, an essential amino acid, is energetically advantageous and chemically stable. The optimal configuration with the largest total energy difference (73.646 kcal/mol) and chemical rigidity (0.144 eV) is the Zn<inf>3</inf>(PO<inf>4</inf>)<inf>2</inf>–lysine molecular system, in which the interaction occurs through the ionized H-amino group of lysine. The results of the analysis of the microstructure of zinc phosphate nanoparticles stabilized with L-lysine show that the surface of the samples consists of large aggregates with diameters of 6–17 Pn, which are small spherical particles with dimensions of 100–150 nm. The results of the analysis of the elemental composition allowed us to establish the presence of elements such as zinc and phosphorus in the structure. The phase composition of the samples is studied, as a result, it is determined that the sample of zinc phosphate nanoparticles stabilized with L-lysine has orthorhombic syngony with the space group P nma. The samples were examined by IR spectroscopy, which revealed that the amino acid interaction occurs when phosphate binds through amino groups in the amino acid molecule.
format	Статья
author	Blinova, A. A. Блинова, А. А. Rekhman, Z. A. Рехман, З. А. Blinov, A. V. Блинов, А. В. Lapin, V. A. Лапин, В. А. Pirogov, M. A. Пирогов, М. А.
author_facet	Blinova, A. A. Блинова, А. А. Rekhman, Z. A. Рехман, З. А. Blinov, A. V. Блинов, А. В. Lapin, V. A. Лапин, В. А. Pirogov, M. A. Пирогов, М. А.
author_sort	Blinova, A. A.
title	SYNTHESIS OF NANOSIZED ZINC PHOSPHATE STABILIZED WITH BIOLOGICALLY ACTIVE SUBSTANCES
title_short	SYNTHESIS OF NANOSIZED ZINC PHOSPHATE STABILIZED WITH BIOLOGICALLY ACTIVE SUBSTANCES
title_full	SYNTHESIS OF NANOSIZED ZINC PHOSPHATE STABILIZED WITH BIOLOGICALLY ACTIVE SUBSTANCES
title_fullStr	SYNTHESIS OF NANOSIZED ZINC PHOSPHATE STABILIZED WITH BIOLOGICALLY ACTIVE SUBSTANCES
title_full_unstemmed	SYNTHESIS OF NANOSIZED ZINC PHOSPHATE STABILIZED WITH BIOLOGICALLY ACTIVE SUBSTANCES
title_sort	synthesis of nanosized zinc phosphate stabilized with biologically active substances
publisher	Bauman Press
publishDate	2025
url	https://dspace.ncfu.ru/handle/123456789/31847
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SYNTHESIS OF NANOSIZED ZINC PHOSPHATE STABILIZED WITH BIOLOGICALLY ACTIVE SUBSTANCES

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