Facile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [e]-fused 1H-pyrrole-2,3-diones with thiourea
A highly divergent synthesis of regioisomeric thiohydantoins and pseudothiohydantoins spiro-fused to a pharmacologically valuable pyrrole-2-one fragment involving the reaction of [e]-fused 1H-pyrrole-2,3-diones with thioureas was developed. The obtained spiro pseudothiohydantoin derivatives were fou...
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| Главные авторы: | , |
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| Формат: | Статья |
| Язык: | English |
| Опубликовано: |
Beilstein-Institut
2019
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| Темы: | |
| Online-ссылка: | http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=14&SID=C5tCb5mJo32occO9TBf&page=1&doc=1 https://dspace.ncfu.ru/handle/20.500.12258/10019 |
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| Краткое описание: | A highly divergent synthesis of regioisomeric thiohydantoins and pseudothiohydantoins spiro-fused to a pharmacologically valuable pyrrole-2-one fragment involving the reaction of [e]-fused 1H-pyrrole-2,3-diones with thioureas was developed. The obtained spiro pseudothiohydantoin derivatives were found to undergo a pseudothiohydantoin-thiohydantoin rearrangement. The reactions were shown to proceed under catalyst-free conditions in good yields, and the products were isolated without applying preparative chromatography methods |
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