Facile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [e]-fused 1H-pyrrole-2,3-diones with thiourea

A highly divergent synthesis of regioisomeric thiohydantoins and pseudothiohydantoins spiro-fused to a pharmacologically valuable pyrrole-2-one fragment involving the reaction of [e]-fused 1H-pyrrole-2,3-diones with thioureas was developed. The obtained spiro pseudothiohydantoin derivatives were fou...

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Autores principales:	Rubin, M. A., Рубин, М. А.
Formato:	Статья
Lenguaje:	English
Publicado:	Beilstein-Institut 2019
Materias:	Nitrogen heterocycles Rearrangement Diversity-oriented synthesis Hydantoin Thiourea
Acceso en línea:	http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=14&SID=C5tCb5mJo32occO9TBf&page=1&doc=1 https://dspace.ncfu.ru/handle/20.500.12258/10019
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spelling	ir-20.500.12258-100192020-02-13T10:10:54Z Facile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [e]-fused 1H-pyrrole-2,3-diones with thiourea Rubin, M. A. Рубин, М. А. Nitrogen heterocycles Rearrangement Diversity-oriented synthesis Hydantoin Thiourea A highly divergent synthesis of regioisomeric thiohydantoins and pseudothiohydantoins spiro-fused to a pharmacologically valuable pyrrole-2-one fragment involving the reaction of [e]-fused 1H-pyrrole-2,3-diones with thioureas was developed. The obtained spiro pseudothiohydantoin derivatives were found to undergo a pseudothiohydantoin-thiohydantoin rearrangement. The reactions were shown to proceed under catalyst-free conditions in good yields, and the products were isolated without applying preparative chromatography methods 2019-12-20T12:36:15Z 2019-12-20T12:36:15Z 2019 Статья Kobelev, AI; Tretyakov, NA; Stepanova, EE; Dmitriev, MV; Rubin, M; Maslivets, AN. Facile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [e]-fused 1H-pyrrole-2,3-diones with thiourea // BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY. - 2019. - Том: 15. - Стр.: 2864-2871 http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=14&SID=C5tCb5mJo32occO9TBf&page=1&doc=1 http://hdl.handle.net/20.500.12258/10019 en Beilstein Journal of Organic Chemistry application/pdf application/pdf Beilstein-Institut
institution	СКФУ
collection	Репозиторий
language	English
topic	Nitrogen heterocycles Rearrangement Diversity-oriented synthesis Hydantoin Thiourea
spellingShingle	Nitrogen heterocycles Rearrangement Diversity-oriented synthesis Hydantoin Thiourea Rubin, M. A. Рубин, М. А. Facile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [e]-fused 1H-pyrrole-2,3-diones with thiourea
description	A highly divergent synthesis of regioisomeric thiohydantoins and pseudothiohydantoins spiro-fused to a pharmacologically valuable pyrrole-2-one fragment involving the reaction of [e]-fused 1H-pyrrole-2,3-diones with thioureas was developed. The obtained spiro pseudothiohydantoin derivatives were found to undergo a pseudothiohydantoin-thiohydantoin rearrangement. The reactions were shown to proceed under catalyst-free conditions in good yields, and the products were isolated without applying preparative chromatography methods
format	Статья
author	Rubin, M. A. Рубин, М. А.
author_facet	Rubin, M. A. Рубин, М. А.
author_sort	Rubin, M. A.
title	Facile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [e]-fused 1H-pyrrole-2,3-diones with thiourea
title_short	Facile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [e]-fused 1H-pyrrole-2,3-diones with thiourea
title_full	Facile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [e]-fused 1H-pyrrole-2,3-diones with thiourea
title_fullStr	Facile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [e]-fused 1H-pyrrole-2,3-diones with thiourea
title_full_unstemmed	Facile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [e]-fused 1H-pyrrole-2,3-diones with thiourea
title_sort	facile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [e]-fused 1h-pyrrole-2,3-diones with thiourea
publisher	Beilstein-Institut
publishDate	2019
url	http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=14&SID=C5tCb5mJo32occO9TBf&page=1&doc=1 https://dspace.ncfu.ru/handle/20.500.12258/10019
work_keys_str_mv	AT rubinma facileregiodivergentsynthesisofspiropyrrolesubstitutedpseudothiohydantoinsandthiohydantoinsviareactionofefused1hpyrrole23dioneswiththiourea AT rubinma facileregiodivergentsynthesisofspiropyrrolesubstitutedpseudothiohydantoinsandthiohydantoinsviareactionofefused1hpyrrole23dioneswiththiourea
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Facile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [e]-fused 1H-pyrrole-2,3-diones with thiourea

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