Synthesis, crystal structures, spectroscopic, and cytotoxicity study of Cu(II), Co(II), Ni(II) and Pd(II) complexes with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione

The coordination compounds of Cu(II), Co(II), Ni(II) and Pd(II) with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione (HL) of the composition [ML2(C2H5OH)2]·nH2O (M = Co (n = 1), Ni (n = 0)) and [ML2] (M = Cu, Pd) have been prepared and investigated by elemental analysis, IR-spectroscopy, NMR...

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Главные авторы:	Dotsenko, V. V., Доценко, В. В.
Formato:	Статья
Idioma:	English
Publicado em:	Elsevier Ltd 2020
Assuntos:	Mononuclear complexes β-Enaminone Crystal structures Cytotoxicity Hep-2
Acesso em linha:	https://www.scopus.com/record/display.uri?eid=2-s2.0-85077316510&origin=resultslist&sort=plf-f&src=s&st1=Synthesis%2c+crystal+structures%2c+spectroscopic%2c+and+cytotoxicity+study+of+Cu&st2=&sid=454db2659ff8ab2825719fcf6f897454&sot=b&sdt=b&sl=89&s=TITLE-ABS-KEY%28Synthesis%2c+crystal+structures%2c+spectroscopic%2c+and+cytotoxicity+study+of+Cu%29&relpos=0&citeCnt=0&searchTerm= https://dspace.ncfu.ru/handle/20.500.12258/11211
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spelling	ir-20.500.12258-112112020-06-22T12:11:38Z Synthesis, crystal structures, spectroscopic, and cytotoxicity study of Cu(II), Co(II), Ni(II) and Pd(II) complexes with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione Dotsenko, V. V. Доценко, В. В. Mononuclear complexes β-Enaminone Crystal structures Cytotoxicity Hep-2 The coordination compounds of Cu(II), Co(II), Ni(II) and Pd(II) with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione (HL) of the composition [ML2(C2H5OH)2]·nH2O (M = Co (n = 1), Ni (n = 0)) and [ML2] (M = Cu, Pd) have been prepared and investigated by elemental analysis, IR-spectroscopy, NMR spectroscopy, powder X-ray diffraction analysis. Single-crystal X-ray diffraction analysis shows that HL serves as a chelate bidentate ligand coordinated to the metal ion through the N and O atoms forming a six-membered chelate ring. The coordination polyhedron of the metal atoms is a square bipyramid [ML2(C2H5OH)2] or square planar [ML2]. The Cu(II) and Pd(II) complexes stability in solution has been shown by NMR spectroscopy. The results of the cell viability study on Hep2 (human larynx carcinoma) cells demonstrate that the complexes don't exhibit strong cytotoxic effect against Hep-2 cell line compared to cisplatin (IC50 = 9,2 ± 0,5 μM). Palladium(II) complex is the most cytotoxic among all complexes and shows IC50 value of 68,7 ± 5,3 μM 2020-01-29T14:20:05Z 2020-01-29T14:20:05Z 2020 Статья Eremina, J.A., Lider, E.V., Sukhikh, T.S., Eltsov, I.V., Kuratieva, N.V., Zakharov, B.A., Sheludyakova, L.A., Klyushova, L.S., Ermakova, E.A., Dotsenko, V.V. Synthesis, crystal structures, spectroscopic, and cytotoxicity study of Cu(II), Co(II), Ni(II) and Pd(II) complexes with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione // Polyhedron. - 2020. - Volume 178. - Номер статьи 114325 https://www.scopus.com/record/display.uri?eid=2-s2.0-85077316510&origin=resultslist&sort=plf-f&src=s&st1=Synthesis%2c+crystal+structures%2c+spectroscopic%2c+and+cytotoxicity+study+of+Cu&st2=&sid=454db2659ff8ab2825719fcf6f897454&sot=b&sdt=b&sl=89&s=TITLE-ABS-KEY%28Synthesis%2c+crystal+structures%2c+spectroscopic%2c+and+cytotoxicity+study+of+Cu%29&relpos=0&citeCnt=0&searchTerm= http://hdl.handle.net/20.500.12258/11211 en Polyhedron application/pdf application/pdf Elsevier Ltd
institution	СКФУ
collection	Репозиторий
language	English
topic	Mononuclear complexes β-Enaminone Crystal structures Cytotoxicity Hep-2
spellingShingle	Mononuclear complexes β-Enaminone Crystal structures Cytotoxicity Hep-2 Dotsenko, V. V. Доценко, В. В. Synthesis, crystal structures, spectroscopic, and cytotoxicity study of Cu(II), Co(II), Ni(II) and Pd(II) complexes with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione
description	The coordination compounds of Cu(II), Co(II), Ni(II) and Pd(II) with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione (HL) of the composition [ML2(C2H5OH)2]·nH2O (M = Co (n = 1), Ni (n = 0)) and [ML2] (M = Cu, Pd) have been prepared and investigated by elemental analysis, IR-spectroscopy, NMR spectroscopy, powder X-ray diffraction analysis. Single-crystal X-ray diffraction analysis shows that HL serves as a chelate bidentate ligand coordinated to the metal ion through the N and O atoms forming a six-membered chelate ring. The coordination polyhedron of the metal atoms is a square bipyramid [ML2(C2H5OH)2] or square planar [ML2]. The Cu(II) and Pd(II) complexes stability in solution has been shown by NMR spectroscopy. The results of the cell viability study on Hep2 (human larynx carcinoma) cells demonstrate that the complexes don't exhibit strong cytotoxic effect against Hep-2 cell line compared to cisplatin (IC50 = 9,2 ± 0,5 μM). Palladium(II) complex is the most cytotoxic among all complexes and shows IC50 value of 68,7 ± 5,3 μM
format	Статья
author	Dotsenko, V. V. Доценко, В. В.
author_facet	Dotsenko, V. V. Доценко, В. В.
author_sort	Dotsenko, V. V.
title	Synthesis, crystal structures, spectroscopic, and cytotoxicity study of Cu(II), Co(II), Ni(II) and Pd(II) complexes with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione
title_short	Synthesis, crystal structures, spectroscopic, and cytotoxicity study of Cu(II), Co(II), Ni(II) and Pd(II) complexes with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione
title_full	Synthesis, crystal structures, spectroscopic, and cytotoxicity study of Cu(II), Co(II), Ni(II) and Pd(II) complexes with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione
title_fullStr	Synthesis, crystal structures, spectroscopic, and cytotoxicity study of Cu(II), Co(II), Ni(II) and Pd(II) complexes with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione
title_full_unstemmed	Synthesis, crystal structures, spectroscopic, and cytotoxicity study of Cu(II), Co(II), Ni(II) and Pd(II) complexes with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione
title_sort	synthesis, crystal structures, spectroscopic, and cytotoxicity study of cu(ii), co(ii), ni(ii) and pd(ii) complexes with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione
publisher	Elsevier Ltd
publishDate	2020
url	https://www.scopus.com/record/display.uri?eid=2-s2.0-85077316510&origin=resultslist&sort=plf-f&src=s&st1=Synthesis%2c+crystal+structures%2c+spectroscopic%2c+and+cytotoxicity+study+of+Cu&st2=&sid=454db2659ff8ab2825719fcf6f897454&sot=b&sdt=b&sl=89&s=TITLE-ABS-KEY%28Synthesis%2c+crystal+structures%2c+spectroscopic%2c+and+cytotoxicity+study+of+Cu%29&relpos=0&citeCnt=0&searchTerm= https://dspace.ncfu.ru/handle/20.500.12258/11211
work_keys_str_mv	AT dotsenkovv synthesiscrystalstructuresspectroscopicandcytotoxicitystudyofcuiicoiiniiiandpdiicomplexeswith2anilinomethylidene55dimethylcyclohexane13dione AT docenkovv synthesiscrystalstructuresspectroscopicandcytotoxicitystudyofcuiicoiiniiiandpdiicomplexeswith2anilinomethylidene55dimethylcyclohexane13dione
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Synthesis, crystal structures, spectroscopic, and cytotoxicity study of Cu(II), Co(II), Ni(II) and Pd(II) complexes with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione

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