Histological studies of organs in experiment on the application of a niosomal form of anti-tumor medicine
The study of histological changes showed that encapsulation of the antitumor substance N-hydroxy-2-(2-(naphthalen-2-yl)-1H-indol-3-yl)-2-phenylacetamide in niosomes increases its cytotoxicity. This is due to the peculiarities of the phar-macokinetics of niosomal drugs. When the antitumor substance i...
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Stavropol State Medical University
2020
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ir-20.500.12258-116132023-09-26T13:56:23Z Histological studies of organs in experiment on the application of a niosomal form of anti-tumor medicine Aksenov, A. V. Аксенов, А. В. Glioblastoma Niosomal form of N-hydroxy-2-(2-(naphthalen-2-yl)-1H-indol-3-yl)-2-phenylacetamide Pathomorphological changes The study of histological changes showed that encapsulation of the antitumor substance N-hydroxy-2-(2-(naphthalen-2-yl)-1H-indol-3-yl)-2-phenylacetamide in niosomes increases its cytotoxicity. This is due to the peculiarities of the phar-macokinetics of niosomal drugs. When the antitumor substance is encapsulated in niosomes, its metabolism is slower in the liver, and due to this the substance is in the peripheral blood for a longer time at higher concentrations compared to the introduction of the antitumor substance in its pure form 2020-03-03T09:23:03Z 2020-03-03T09:23:03Z 2019 Статья Bazikov, I.A., Aksenov, A.V., Maltsev, A.N., Botasheva, V.S., Kornienko, A.V., Korolkova, V.I., Bazikov, F.I. Histological studies of organs in experiment on the application of a niosomal form of anti-tumor medicine // Medical News of North Caucasus. - 2019. - Volume 14. - Issue 4. - Pages 672-676 http://hdl.handle.net/20.500.12258/11613 ru Medical News of North Caucasus application/pdf Stavropol State Medical University |
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СКФУ |
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Репозиторий |
| language |
Russian |
| topic |
Glioblastoma Niosomal form of N-hydroxy-2-(2-(naphthalen-2-yl)-1H-indol-3-yl)-2-phenylacetamide Pathomorphological changes |
| spellingShingle |
Glioblastoma Niosomal form of N-hydroxy-2-(2-(naphthalen-2-yl)-1H-indol-3-yl)-2-phenylacetamide Pathomorphological changes Aksenov, A. V. Аксенов, А. В. Histological studies of organs in experiment on the application of a niosomal form of anti-tumor medicine |
| description |
The study of histological changes showed that encapsulation of the antitumor substance N-hydroxy-2-(2-(naphthalen-2-yl)-1H-indol-3-yl)-2-phenylacetamide in niosomes increases its cytotoxicity. This is due to the peculiarities of the phar-macokinetics of niosomal drugs. When the antitumor substance is encapsulated in niosomes, its metabolism is slower in the liver, and due to this the substance is in the peripheral blood for a longer time at higher concentrations compared to the introduction of the antitumor substance in its pure form |
| format |
Статья |
| author |
Aksenov, A. V. Аксенов, А. В. |
| author_facet |
Aksenov, A. V. Аксенов, А. В. |
| author_sort |
Aksenov, A. V. |
| title |
Histological studies of organs in experiment on the application of a niosomal form of anti-tumor medicine |
| title_short |
Histological studies of organs in experiment on the application of a niosomal form of anti-tumor medicine |
| title_full |
Histological studies of organs in experiment on the application of a niosomal form of anti-tumor medicine |
| title_fullStr |
Histological studies of organs in experiment on the application of a niosomal form of anti-tumor medicine |
| title_full_unstemmed |
Histological studies of organs in experiment on the application of a niosomal form of anti-tumor medicine |
| title_sort |
histological studies of organs in experiment on the application of a niosomal form of anti-tumor medicine |
| publisher |
Stavropol State Medical University |
| publishDate |
2020 |
| url |
https://dspace.ncfu.ru/handle/20.500.12258/11613 |
| work_keys_str_mv |
AT aksenovav histologicalstudiesoforgansinexperimentontheapplicationofaniosomalformofantitumormedicine AT aksenovav histologicalstudiesoforgansinexperimentontheapplicationofaniosomalformofantitumormedicine |
| _version_ |
1809808152895422464 |