Nitroalkanes as electrophiles: synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity

We discovered a reaction of nitroalkanes with 2-hydrazinylquinolines, 2-hydrazinylpyridines and bis-2,4-dihydrazinylpyrimidines in polyphosphoric acid (PPA) affording 1,2,4-triazolo[4,3-a]quinolines, 1,2,4-triazolo[4,3-a]pyridines and bis[1,2,4]triazolo[4,3-a:4',3'-c]pyrimidines, respectiv...

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Главные авторы:	Aksenov, N. A., Аксенов, Н. А., Aksenov, A. V., Аксенов, А. В., Kirilov, N. K., Кирилов, Н. К., Arutiunov, N. A., Арутюнов, Н. А., Aksenov, D. A., Аксенов, Д. А., Rubin, M. A., Рубин, М. А.
Формат:	Статья
Язык:	English
Опубликовано:	NLM (Medline) 2020
Темы:	Neuroblastoma Nitroalkanes Synthesis of triazole-fused heterocycles Neuroblastoma therapy
Online-ссылка:	https://dspace.ncfu.ru/handle/20.500.12258/13876
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!

id	ir-20.500.12258-13876
record_format	dspace
spelling	ir-20.500.12258-138762025-02-12T13:38:52Z Nitroalkanes as electrophiles: synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity Aksenov, N. A. Аксенов, Н. А. Aksenov, A. V. Аксенов, А. В. Kirilov, N. K. Кирилов, Н. К. Arutiunov, N. A. Арутюнов, Н. А. Aksenov, D. A. Аксенов, Д. А. Rubin, M. A. Рубин, М. А. Neuroblastoma Nitroalkanes Synthesis of triazole-fused heterocycles Neuroblastoma therapy We discovered a reaction of nitroalkanes with 2-hydrazinylquinolines, 2-hydrazinylpyridines and bis-2,4-dihydrazinylpyrimidines in polyphosphoric acid (PPA) affording 1,2,4-triazolo[4,3-a]quinolines, 1,2,4-triazolo[4,3-a]pyridines and bis[1,2,4]triazolo[4,3-a:4',3'-c]pyrimidines, respectively. The reaction expands the scope of heterocyclic annulations involving phosphorylated nitronates, believed to be the electrophilic intermediates formed from nitroalkanes in PPA. Several of the synthesized triazoles showed promising anticancer activity by inducing differentiation in neuroblastoma cancer cells. Due to the urgent need for novel differentiation agents for neuroblastoma therapy, this finding warrants further evaluation of this class of compounds against neuroblastoma 2020-09-14T09:50:54Z 2020-09-14T09:50:54Z 2020 Статья Aksenov, N.A., Aksenov, A.V., Kirilov, N.K., Arutiunov, N.A., Aksenov, D.A., Maslivetc, V., Zhao, Z., Du, L., Rubin, M., Kornienko, A. Nitroalkanes as electrophiles: synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity // Organic & biomolecular chemistry. - 2020. - Volume 18. - Issue 34. - Pages 6651-6664 http://hdl.handle.net/20.500.12258/13876 en Organic and Biomolecular Chemistry application/pdf application/pdf NLM (Medline)
institution	СКФУ
collection	Репозиторий
language	English
topic	Neuroblastoma Nitroalkanes Synthesis of triazole-fused heterocycles Neuroblastoma therapy
spellingShingle	Neuroblastoma Nitroalkanes Synthesis of triazole-fused heterocycles Neuroblastoma therapy Aksenov, N. A. Аксенов, Н. А. Aksenov, A. V. Аксенов, А. В. Kirilov, N. K. Кирилов, Н. К. Arutiunov, N. A. Арутюнов, Н. А. Aksenov, D. A. Аксенов, Д. А. Rubin, M. A. Рубин, М. А. Nitroalkanes as electrophiles: synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity
description	We discovered a reaction of nitroalkanes with 2-hydrazinylquinolines, 2-hydrazinylpyridines and bis-2,4-dihydrazinylpyrimidines in polyphosphoric acid (PPA) affording 1,2,4-triazolo[4,3-a]quinolines, 1,2,4-triazolo[4,3-a]pyridines and bis[1,2,4]triazolo[4,3-a:4',3'-c]pyrimidines, respectively. The reaction expands the scope of heterocyclic annulations involving phosphorylated nitronates, believed to be the electrophilic intermediates formed from nitroalkanes in PPA. Several of the synthesized triazoles showed promising anticancer activity by inducing differentiation in neuroblastoma cancer cells. Due to the urgent need for novel differentiation agents for neuroblastoma therapy, this finding warrants further evaluation of this class of compounds against neuroblastoma
format	Статья
author	Aksenov, N. A. Аксенов, Н. А. Aksenov, A. V. Аксенов, А. В. Kirilov, N. K. Кирилов, Н. К. Arutiunov, N. A. Арутюнов, Н. А. Aksenov, D. A. Аксенов, Д. А. Rubin, M. A. Рубин, М. А.
author_facet	Aksenov, N. A. Аксенов, Н. А. Aksenov, A. V. Аксенов, А. В. Kirilov, N. K. Кирилов, Н. К. Arutiunov, N. A. Арутюнов, Н. А. Aksenov, D. A. Аксенов, Д. А. Rubin, M. A. Рубин, М. А.
author_sort	Aksenov, N. A.
title	Nitroalkanes as electrophiles: synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity
title_short	Nitroalkanes as electrophiles: synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity
title_full	Nitroalkanes as electrophiles: synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity
title_fullStr	Nitroalkanes as electrophiles: synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity
title_full_unstemmed	Nitroalkanes as electrophiles: synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity
title_sort	nitroalkanes as electrophiles: synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity
publisher	NLM (Medline)
publishDate	2020
url	https://dspace.ncfu.ru/handle/20.500.12258/13876
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Nitroalkanes as electrophiles: synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity

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