Preparation of spiro[indole-3,5′-isoxazoles] via Grignard conjugate addition/spirocyclization sequence

A highly efficient one-pot procedure combining conjugate addition of Grignard reagents to (2-nitroalkenyl)indoles and sub-sequent Brønsted acid-assisted spirocyclization allowed for preparation of 4′H-spiro[indole-3,5′-isoxazoles] in a diastereomerically selective fashion. Utilization of alkyl Grign...

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Главные авторы:	Aksenov, A. V., Аксенов, А. В., Aksenov, D. A., Аксенов, Д. А., Aksenov, N. A., Аксенов, Н. А., Skomorokhov, A. A., Скоморохов, А. А., Aleksandrova, E. V., Александрова, Е. В., Rubin, M. A., Рубин, М. А.
Формат:	Статья
Язык:	English
Опубликовано:	Royal Society of Chemistry 2021
Темы:	Addition reactions Reagents Alkyl-substituted derivatives Polycyclic aromatic hydrocarbons
Online-ссылка:	https://dspace.ncfu.ru/handle/20.500.12258/14853
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spelling	ir-20.500.12258-148532025-02-13T09:15:12Z Preparation of spiro[indole-3,5′-isoxazoles] via Grignard conjugate addition/spirocyclization sequence Aksenov, A. V. Аксенов, А. В. Aksenov, D. A. Аксенов, Д. А. Aksenov, N. A. Аксенов, Н. А. Skomorokhov, A. A. Скоморохов, А. А. Aleksandrova, E. V. Александрова, Е. В. Rubin, M. A. Рубин, М. А. Addition reactions Reagents Alkyl-substituted derivatives Polycyclic aromatic hydrocarbons A highly efficient one-pot procedure combining conjugate addition of Grignard reagents to (2-nitroalkenyl)indoles and sub-sequent Brønsted acid-assisted spirocyclization allowed for preparation of 4′H-spiro[indole-3,5′-isoxazoles] in a diastereomerically selective fashion. Utilization of alkyl Grignard reagents provided an easy access to 4′-alkylsubstituted derivatives hardly available by other means 2021-02-02T13:43:48Z 2021-02-02T13:43:48Z 2021 Статья Aksenov, A.V., Aksenov, D.A., Aksenov, N.A., Skomorokhov, A.A., Aleksandrova, E.V., Rubin, M. Preparation of spiro[indole-3,5′-isoxazoles] via Grignard conjugate addition/spirocyclization sequence // RSC Advances. - 2021. - Volume 11. - Issue 3. - Pages 1783-1793 http://hdl.handle.net/20.500.12258/14853 en RSC Advances application/pdf application/pdf Royal Society of Chemistry
institution	СКФУ
collection	Репозиторий
language	English
topic	Addition reactions Reagents Alkyl-substituted derivatives Polycyclic aromatic hydrocarbons
spellingShingle	Addition reactions Reagents Alkyl-substituted derivatives Polycyclic aromatic hydrocarbons Aksenov, A. V. Аксенов, А. В. Aksenov, D. A. Аксенов, Д. А. Aksenov, N. A. Аксенов, Н. А. Skomorokhov, A. A. Скоморохов, А. А. Aleksandrova, E. V. Александрова, Е. В. Rubin, M. A. Рубин, М. А. Preparation of spiro[indole-3,5′-isoxazoles] via Grignard conjugate addition/spirocyclization sequence
description	A highly efficient one-pot procedure combining conjugate addition of Grignard reagents to (2-nitroalkenyl)indoles and sub-sequent Brønsted acid-assisted spirocyclization allowed for preparation of 4′H-spiro[indole-3,5′-isoxazoles] in a diastereomerically selective fashion. Utilization of alkyl Grignard reagents provided an easy access to 4′-alkylsubstituted derivatives hardly available by other means
format	Статья
author	Aksenov, A. V. Аксенов, А. В. Aksenov, D. A. Аксенов, Д. А. Aksenov, N. A. Аксенов, Н. А. Skomorokhov, A. A. Скоморохов, А. А. Aleksandrova, E. V. Александрова, Е. В. Rubin, M. A. Рубин, М. А.
author_facet	Aksenov, A. V. Аксенов, А. В. Aksenov, D. A. Аксенов, Д. А. Aksenov, N. A. Аксенов, Н. А. Skomorokhov, A. A. Скоморохов, А. А. Aleksandrova, E. V. Александрова, Е. В. Rubin, M. A. Рубин, М. А.
author_sort	Aksenov, A. V.
title	Preparation of spiro[indole-3,5′-isoxazoles] via Grignard conjugate addition/spirocyclization sequence
title_short	Preparation of spiro[indole-3,5′-isoxazoles] via Grignard conjugate addition/spirocyclization sequence
title_full	Preparation of spiro[indole-3,5′-isoxazoles] via Grignard conjugate addition/spirocyclization sequence
title_fullStr	Preparation of spiro[indole-3,5′-isoxazoles] via Grignard conjugate addition/spirocyclization sequence
title_full_unstemmed	Preparation of spiro[indole-3,5′-isoxazoles] via Grignard conjugate addition/spirocyclization sequence
title_sort	preparation of spiro[indole-3,5′-isoxazoles] via grignard conjugate addition/spirocyclization sequence
publisher	Royal Society of Chemistry
publishDate	2021
url	https://dspace.ncfu.ru/handle/20.500.12258/14853
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Preparation of spiro[indole-3,5′-isoxazoles] via Grignard conjugate addition/spirocyclization sequence

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