1,6-Diamino-2-oxopyridine-3,5-dicarbonitrile Derivatives in the Mannich Reaction

1,6-Diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitriles under the action of primary aliphatic amines and an excess of 37% formalin in ethanol were converted into 2,3,8,9-tetrahydro-6,10-methano[1,2,4]triazolo[1,5-a][1,5]diazocine-6,10(7H)-dicarbonitrile derivatives. At the same time, the Ma...

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Главные авторы:	Dotsenko, V. V., Доценко, В. В., Aksenov, N. A., Аксенов, Н. А., Aksenova, I. V., Аксенова, И. В.
Formato:	Статья
Idioma:	English
Publicado em:	Pleiades journals 2021
Assuntos:	1,2,4-triazolo[1,5-a]pyridines 2-cyanoacethydrazide 3,7-diazabicyclo[3.3.1]nonanes aminomethylation Mannich reaction
Acesso em linha:	https://dspace.ncfu.ru/handle/20.500.12258/15477
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id	ir-20.500.12258-15477
record_format	dspace
spelling	ir-20.500.12258-154772021-03-19T07:40:41Z 1,6-Diamino-2-oxopyridine-3,5-dicarbonitrile Derivatives in the Mannich Reaction Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. 1,2,4-triazolo[1,5-a]pyridines 2-cyanoacethydrazide 3,7-diazabicyclo[3.3.1]nonanes aminomethylation Mannich reaction 1,6-Diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitriles under the action of primary aliphatic amines and an excess of 37% formalin in ethanol were converted into 2,3,8,9-tetrahydro-6,10-methano[1,2,4]triazolo[1,5-a][1,5]diazocine-6,10(7H)-dicarbonitrile derivatives. At the same time, the Mannich reaction in the case of 1,6-diamino-4-aryl-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles proceeds ambiguously, and, depending on the conditions, gives either N-ethoxymethylation products or 1,2,4-triazolo[1,5-a]pyridine derivatives. In silico predictive analysis of the biological activity of new compounds was carried out 2021-03-18T12:52:15Z 2021-03-18T12:52:15Z 2021 Статья Dotsenko, V.V., Khrustaleva, A.N., Frolov, K.A., Aksenov, N.A., Aksenova, I.V., Krivokolysko, S.G. 1,6-Diamino-2-oxopyridine-3,5-dicarbonitrile Derivatives in the Mannich Reaction // Russian Journal of General Chemistry. - 2021. - Volume 91. - Issue 1. - Pages 44-56 http://hdl.handle.net/20.500.12258/15477 en Russian Journal of General Chemistry application/pdf application/pdf Pleiades journals
institution	СКФУ
collection	Репозиторий
language	English
topic	1,2,4-triazolo[1,5-a]pyridines 2-cyanoacethydrazide 3,7-diazabicyclo[3.3.1]nonanes aminomethylation Mannich reaction
spellingShingle	1,2,4-triazolo[1,5-a]pyridines 2-cyanoacethydrazide 3,7-diazabicyclo[3.3.1]nonanes aminomethylation Mannich reaction Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. 1,6-Diamino-2-oxopyridine-3,5-dicarbonitrile Derivatives in the Mannich Reaction
description	1,6-Diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitriles under the action of primary aliphatic amines and an excess of 37% formalin in ethanol were converted into 2,3,8,9-tetrahydro-6,10-methano[1,2,4]triazolo[1,5-a][1,5]diazocine-6,10(7H)-dicarbonitrile derivatives. At the same time, the Mannich reaction in the case of 1,6-diamino-4-aryl-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles proceeds ambiguously, and, depending on the conditions, gives either N-ethoxymethylation products or 1,2,4-triazolo[1,5-a]pyridine derivatives. In silico predictive analysis of the biological activity of new compounds was carried out
format	Статья
author	Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В.
author_facet	Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В.
author_sort	Dotsenko, V. V.
title	1,6-Diamino-2-oxopyridine-3,5-dicarbonitrile Derivatives in the Mannich Reaction
title_short	1,6-Diamino-2-oxopyridine-3,5-dicarbonitrile Derivatives in the Mannich Reaction
title_full	1,6-Diamino-2-oxopyridine-3,5-dicarbonitrile Derivatives in the Mannich Reaction
title_fullStr	1,6-Diamino-2-oxopyridine-3,5-dicarbonitrile Derivatives in the Mannich Reaction
title_full_unstemmed	1,6-Diamino-2-oxopyridine-3,5-dicarbonitrile Derivatives in the Mannich Reaction
title_sort	1,6-diamino-2-oxopyridine-3,5-dicarbonitrile derivatives in the mannich reaction
publisher	Pleiades journals
publishDate	2021
url	https://dspace.ncfu.ru/handle/20.500.12258/15477
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1,6-Diamino-2-oxopyridine-3,5-dicarbonitrile Derivatives in the Mannich Reaction

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