Synthesis and analgesic activity of new heterocyclic cyanothioacetamide derivatives

The reaction of cyanothioacetamide with aromatic aldehydes and 1,3-dicarbonyl compounds followed by aminomethylation or S-alkylation gave a series of heterocyclic derivatives with a 1,2,3,4-tetrahydropyridine or 1,4,5,6,7,8-hexahydroquinoline fragment. The resulting compounds were tested for analges...

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Главные авторы:	Dotsenko, V. V., Доценко, В. В., Aksenov, N. A., Аксенов, Н. А., Aksenova, I. V., Аксенова, И. В., Shcherbakov, S. V., Щербаков, С. В., Ovcharov, S. N., Овчаров, С. Н.
Формат:	Статья
Язык:	English
Опубликовано:	Pleiades journals 2021
Темы:	2-oxo-3-cyano-1,4,5,6-tetrahydropyridine-2-thiolates Analgesics Cyanothioacetamide Mannich reaction Pyrido[2,1-b][1,3,5]thiadiazines
Online-ссылка:	https://dspace.ncfu.ru/handle/20.500.12258/15557
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spelling	ir-20.500.12258-155572025-02-13T09:12:17Z Synthesis and analgesic activity of new heterocyclic cyanothioacetamide derivatives Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. Shcherbakov, S. V. Щербаков, С. В. Ovcharov, S. N. Овчаров, С. Н. 2-oxo-3-cyano-1,4,5,6-tetrahydropyridine-2-thiolates Analgesics Cyanothioacetamide Mannich reaction Pyrido[2,1-b][1,3,5]thiadiazines The reaction of cyanothioacetamide with aromatic aldehydes and 1,3-dicarbonyl compounds followed by aminomethylation or S-alkylation gave a series of heterocyclic derivatives with a 1,2,3,4-tetrahydropyridine or 1,4,5,6,7,8-hexahydroquinoline fragment. The resulting compounds were tested for analgesic activity in vivo. Some of the prepared compounds showed an antinociceptive effect superior to that of ketorolac in dynamics 2021-03-23T12:27:24Z 2021-03-23T12:27:24Z 2021 Статья Bibik, I.V., Bibik, E.Y., Dotsenko, V.V., Frolov, K.A., Krivokolysko, S.G., Aksenov, N.A., Aksenova, I.V., Shcherbakov, S.V., Ovcharov, S.N. Synthesis and analgesic activity of new heterocyclic cyanothioacetamide derivatives // Russian Journal of General Chemistry. - 2021. - Volume 91. - Issue 2. - Pages 154-166 http://hdl.handle.net/20.500.12258/15557 en Russian Journal of General Chemistry application/pdf application/pdf Pleiades journals
institution	СКФУ
collection	Репозиторий
language	English
topic	2-oxo-3-cyano-1,4,5,6-tetrahydropyridine-2-thiolates Analgesics Cyanothioacetamide Mannich reaction Pyrido[2,1-b][1,3,5]thiadiazines
spellingShingle	2-oxo-3-cyano-1,4,5,6-tetrahydropyridine-2-thiolates Analgesics Cyanothioacetamide Mannich reaction Pyrido[2,1-b][1,3,5]thiadiazines Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. Shcherbakov, S. V. Щербаков, С. В. Ovcharov, S. N. Овчаров, С. Н. Synthesis and analgesic activity of new heterocyclic cyanothioacetamide derivatives
description	The reaction of cyanothioacetamide with aromatic aldehydes and 1,3-dicarbonyl compounds followed by aminomethylation or S-alkylation gave a series of heterocyclic derivatives with a 1,2,3,4-tetrahydropyridine or 1,4,5,6,7,8-hexahydroquinoline fragment. The resulting compounds were tested for analgesic activity in vivo. Some of the prepared compounds showed an antinociceptive effect superior to that of ketorolac in dynamics
format	Статья
author	Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. Shcherbakov, S. V. Щербаков, С. В. Ovcharov, S. N. Овчаров, С. Н.
author_facet	Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. Shcherbakov, S. V. Щербаков, С. В. Ovcharov, S. N. Овчаров, С. Н.
author_sort	Dotsenko, V. V.
title	Synthesis and analgesic activity of new heterocyclic cyanothioacetamide derivatives
title_short	Synthesis and analgesic activity of new heterocyclic cyanothioacetamide derivatives
title_full	Synthesis and analgesic activity of new heterocyclic cyanothioacetamide derivatives
title_fullStr	Synthesis and analgesic activity of new heterocyclic cyanothioacetamide derivatives
title_full_unstemmed	Synthesis and analgesic activity of new heterocyclic cyanothioacetamide derivatives
title_sort	synthesis and analgesic activity of new heterocyclic cyanothioacetamide derivatives
publisher	Pleiades journals
publishDate	2021
url	https://dspace.ncfu.ru/handle/20.500.12258/15557
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Synthesis and analgesic activity of new heterocyclic cyanothioacetamide derivatives

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