Synthesis and Regiospecific Bromination of (2E,4E)-5-Aryl-2-(4-arylthiazol-2-yl)penta-2,4-dienenitrile

Synthesis and Regiospecific Bromination of (2E,4E)-5-Aryl-2-(4-arylthiazol-2-yl)penta-2,4-dienenitrile

The reaction of (2E,4E)-5-phenyl-2-cyano-2,4-pentadienethioamide or (E)-3-(2-nitrophenyl)acrolein and cyanothioacetamide with alpha-bromoketones afforded new (2E,4E)-5-aryl-2-(4-arylthiazol-2-yl)penta-2,4-dienenitriles. Direct bromination of the latter by the action of bromine in DMF proceeded regio...

Full description

Saved in:

Bibliographic Details
Main Authors:	Dotsenko, V. V., Доценко, В. В., Aksenov, N. A., Аксенов, Н. А., Aksenova, I. V., Аксенова, И. В., Shcherbakov, S. V., Щербаков, С. В., Ovcharov, S. N., Овчаров, С. Н.
Format:	Статья
Language:	English
Published:	MAIK NAUKA/INTERPERIODICA/SPRINGER 2021
Subjects:	Cyanothioacetamide 5-bromothiazoles Knoevenagel condensation (2E; 4E)-5-aryl-2-cyano-2 Bromination Hantzsch thiazole synthesis 4-pentadienethioamides
Online Access:	https://dspace.ncfu.ru/handle/20.500.12258/15993
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

New methods of synthesis, structure and aminomethylation of 4-imino-2-(dicyanomethylene)-3-azaspiro[5.5]undecane-1,5-dicarbonitrile
by: Dotsenko, V. V., et al.
Published: (2021)

(2E,2′E)-2,2′-(1,2,4-Thiadiazole-3,5-diyl)bis[3-arylacrylonitriles]: Synthesis and Antidote Activity Towards 2,4-D Herbicide
by: Dotsenko, V. V., et al.
Published: (2023)

Mannich Reaction Involving 6-Amino-4-methyl-2-(thio)oxo-1,2-dihydropyridine-3,5-dicarbonitriles
by: Strelkov, V. D., et al.
Published: (2023)

New Azepine-Furan Spirocyclic Structures in the Reaction of 4-Aroyl-1,2-dihydrobenzo[d]azepines and 2-Aroyl-4,5-dihydrophenanthreno[1,2-d]azepine with Formaldehyde
by: Demidov, O. P., et al.
Published: (2021)

First Synthesis of 2-Amino-5-hydroxy-4H-chromene-3-carbonitriles from 4-(2-Pyridylazo)resorcinol
by: Dotsenko, V. V., et al.
Published: (2023)

Some new reactions and properties of xanthane hydride (5-amino-1,2,4-dithiazole-3-thione)
by: Dotsenko, V. V., et al.
Published: (2018)

2-Amino-4,5-dihydrothiophene-3-carbonitriles: A New Synthesis, Quantum Chemical Studies, and Mannich-Type Reactions Leading to New Hexahydrothieno[2,3-d]pyrimidines
by: Dotsenko, V. V., et al.
Published: (2021)

Synthesis and Some Properties of 2-Amino-4-aryl-6-hexyl-7-hydroxy-4H-chromene-3-carbonitriles
by: Dotsenko, V. V., et al.
Published: (2023)

Synthesis and Cyclizations of N-(Thieno[2,3-b]pyridin-3-yl)cyanoacetamides
by: Dotsenko, V. V., et al.
Published: (2019)

7-Aryl-3-(hydroxymethyl)-5-oxo-1,2,3,5-tetrahydro[1,2,4]triazolo[1,5-a]pyridine-6,8-dicarbonitriles: Synthesis and Predicted Biological Activity
by: Dotsenko, V. V., et al.
Published: (2022)

Synthesis and analgesic activity of new heterocyclic cyanothioacetamide derivatives
by: Dotsenko, V. V., et al.
Published: (2021)

N-Hydroxymethylation of 3-Aryl-2-cyanoprop-2-enethioamides
by: Dotsenko, V. V., et al.
Published: (2020)

Synthesis and Structure of (2E)-3-Aryl(hetaryl)-2-[5-bromo-4-aryl(hetaryl)-1,3-thiazol-2-yl]acrylonitriles
by: Dotsenko, V. V., et al.
Published: (2021)

Oxidation of 2-Cyanothioacrylamides with Sodium Nitrite in Acidic Medium
by: Dotsenko, V. V., et al.
Published: (2022)

A new Approach to the synthesis of functional derivatives of 3-(4-Pyridinyl)-1H-indole and 4-s(1H-Indol-3-yl)thieno[2,3-b]pyridine
by: Dotsenko, V. V., et al.
Published: (2018)

An access to 1H-cyclopenta[b]pyridine-4,5-diones via condensation of 6-nitro-1,2-o-quinone with arylamines and acetone
by: Demidov, O. P., et al.
Published: (2021)

1,6-Diamino-2-oxopyridine-3,5-dicarbonitrile Derivatives in the Mannich Reaction
by: Dotsenko, V. V., et al.
Published: (2021)

Reaction of 3-Amino-4,6-diarylthieno[2,3-b]pyridine-2-carboxamides with Ninhydrin
by: Dotsenko, V. V., et al.
Published: (2020)

Investigation in the field of quinazolines. 8*. New reaction of N-alkylation of 4,4-diphenyl-3,4-dihydroquinazolines
by: Demidov, O. P., et al.
Published: (2021)

Synthesis and structure of new 3,7-diazabicyclo[3.3.1]nonane derivatives
by: Dotsenko, V. V., et al.
Published: (2018)

Electrochemical Oxidation of 3-Aryl-2-cyanothioacrylamides
by: Dotsenko, V. V., et al.
Published: (2023)

Synthesis and In vivo Evaluation of Hepatoprotective Effects of Novel Sulfur-Containing 1,4-Dihydropyridines and 1,2,3,4-Tetrahydropyridines
by: Dotsenko, V. V., et al.
Published: (2023)

Synthesis and properties of 4,6-Dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile and 3-Amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines
by: Dotsenko, V. V., et al.
Published: (2019)

Empirical determination of the degree of analgesic activity of some new 3-aminothieno[2,3-b]pyridines and 1,4-dihydropyridines based on a complex criterion
by: Dotsenko, V. V., et al.
Published: (2023)

Synthesis and Aminomethylation of 2-Amino-4-(2-chlorophenyl)-6-(dicyanomethyl)-1,4-dihydropyridine-3,5-dicarbonitrile N-Methylmorpholinium Salt
by: Dotsenko, V. V., et al.
Published: (2022)

Synthesis of 1,5-diazocin-2-ones
by: Aksenov, A. V., et al.
Published: (2021)

Aminomethylation of Guareschi imides: synthesis of 2,4-dioxo-1H,5H-3,7-spiro[diazabicyclo[3.3.1]nonane-9,4'-piperidine]-1,5-dicarbonitriles
by: Dotsenko, V. V., et al.
Published: (2018)

Antistress properties of 2-substituted derivatives of quinazoline-4(3Н)-on
by: Manvelyan, E. A., et al.
Published: (2023)

Synthesis and some properties of new 5-Hydroxy-2-[(hetarylthio)methyl]-4H-pyran-4-ones
by: Dotsenko, V. V., et al.
Published: (2021)

E-government in the western European countries, Asia and in the USA
by: Mukhoryanova, O. A., et al.
Published: (2018)

Synthesis and Aminomethylation of 6-Amino-2-(dicyanomethylene)-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitrile Morpholinium Salt
by: Dotsenko, V. V., et al.
Published: (2021)

Synthesis and properties of new 4-oxo-4,5-dihydro-1,3-oxazolium perchlorates
by: Dotsenko, V. V., et al.
Published: (2019)

Michael addition of amines to sterically crowded ortho-benzoquinone completed with unprecedented 1,2-shift of a tert-butyl group
by: Demidov, O. P., et al.
Published: (2021)

7-(2-Aryl-1-cyanovinyl)-1,2,3,4-tetrahydropyrazolo[1,5-a][1,3,5]triazine-8-carbonitriles: Synthesis and Biological Activity
by: Dotsenko, V. V., et al.
Published: (2023)

Synthesis and Structure of 4-Aryl-3,6-dioxo-2,3,4,5,6,7-hexahydroisothiazolo[5,4-b]pyridine-5-carbonitriles
by: Dotsenko, V. V., et al.
Published: (2023)

Oxidation of 4,6-Dimethyl-2-thioxo-1,2-dihydropyridine-3-carbonitriles with Potassium Ferricyanide: Synthesis and Molecular Docking of Bis(pyrid-2-yl) Disulfides
by: Dotsenko, V. V., et al.
Published: (2024)

Alkyl 4-Aryl-6-amino-7- phenyl-3-(phenylimino)-4,7-dihydro- 3H-[1,2]dithiolo[3,4-b]pyridine-5-carboxylates: Synthesis and Agrochemical Studies
by: Dotsenko, V. V., et al.
Published: (2023)

Anticataleptic activity of 2-substituted derivatives of 3(H)-quinazolin-4-one
by: Manvelyan, E. A., et al.
Published: (2021)

Интерфейс V5.2 учебное пособие
by: Шерстнева, О. Г.

4H-Chromenes as 1,3-bielectrophiles in the reaction with 2-aminobenzimidazole: synthesis of pyrimido [1,2-a] benzimidazoles
by: Demidov, O. P., et al.
Published: (2021)