Pseudo-five-component stereoselective synthesis of highly functionalized 3-azabicyclo[3.3.1]nona-2,7-dienes
The reaction of aromatic aldehydes with malononitrile, ethyl or butyl cyanoacetate and acetylacetone in the presence of NaOH under mild conditions (EtOH, 25 degrees C) led to the formation of new series of (1S,5R,6R,9R)/(1R,5S,6S,9S)-2-amino-6,9-diaryl-7-acetyl-8-methyl-4-oxo-5-cyano-3-azabicyclo[3....
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| Главные авторы: | , , , , , |
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| Formato: | Статья |
| Idioma: | English |
| Publicado: |
MAIK NAUKA/INTERPERIODICA/SPRINGER
2021
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| Темы: | |
| Acceso en liña: | https://dspace.ncfu.ru/handle/20.500.12258/16377 |
| Метки: |
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| Краткое описание: | The reaction of aromatic aldehydes with malononitrile, ethyl or butyl cyanoacetate and acetylacetone in the presence of NaOH under mild conditions (EtOH, 25 degrees C) led to the formation of new series of (1S,5R,6R,9R)/(1R,5S,6S,9S)-2-amino-6,9-diaryl-7-acetyl-8-methyl-4-oxo-5-cyano-3-azabicyclo[3.3.1]nona-2,7-diene-1-carboxylic acids esters. A plausible mechanism of the cascade reaction was proposed. |
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