Pseudo-five-component stereoselective synthesis of highly functionalized 3-azabicyclo[3.3.1]nona-2,7-dienes

The reaction of aromatic aldehydes with malononitrile, ethyl or butyl cyanoacetate and acetylacetone in the presence of NaOH under mild conditions (EtOH, 25 degrees C) led to the formation of new series of (1S,5R,6R,9R)/(1R,5S,6S,9S)-2-amino-6,9-diaryl-7-acetyl-8-methyl-4-oxo-5-cyano-3-azabicyclo[3....

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Hlavní autoři:	Dotsenko, V. V., Доценко, В. В., Aksenov, N. A., Аксенов, Н. А., Aksenova, I. V., Аксенова, И. В.
Médium:	Статья
Jazyk:	English
Vydáno:	MAIK NAUKA/INTERPERIODICA/SPRINGER 2021
Témata:	3-azabicyclo[3; 3; 1]nonane 2-amino-4H-pyrans Methylene active nitriles Cyanoacetic ester Multicomponent reactions (MCRs) Cascade reactions
On-line přístup:	https://dspace.ncfu.ru/handle/20.500.12258/16377
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo otaguje tento záznam!

Popis
Shrnutí:	The reaction of aromatic aldehydes with malononitrile, ethyl or butyl cyanoacetate and acetylacetone in the presence of NaOH under mild conditions (EtOH, 25 degrees C) led to the formation of new series of (1S,5R,6R,9R)/(1R,5S,6S,9S)-2-amino-6,9-diaryl-7-acetyl-8-methyl-4-oxo-5-cyano-3-azabicyclo[3.3.1]nona-2,7-diene-1-carboxylic acids esters. A plausible mechanism of the cascade reaction was proposed.

Pseudo-five-component stereoselective synthesis of highly functionalized 3-azabicyclo[3.3.1]nona-2,7-dienes

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