[3 + 2]-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor

Indolizines and pyrazolo[1,5-a]pyridines were prepared via [3 + 2]-cycloaddition of pyridinium ylides to 1-chloro-2-nitrostyrenes. The synthesized molecules were evaluated for antiproliferative activities against a BE(2)-C neuroblastoma cell line with several compounds decreasing the viability of ca...

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Hoofdauteurs:	Aksenov, A. V., Аксенов, А. В., Arutiunov, N. A., Арутюнов, Н. А., Kirilov, N. K., Кирилов, Н. К., Aksenov, D. A., Аксенов, Д. А., Grishin, I. Y., Гришин, И. Ю., Aksenov, N. A., Аксенов, Н. А., Rubin, M. A., Рубин, М. А.
Formaat:	Статья
Taal:	English
Gepubliceerd in:	Royal Society of Chemistry 2021
Onderwerpen:	Indolizines Pyrazolo[1,5-a]pyridines Indolizine 9db Anticancer agents
Online toegang:	https://dspace.ncfu.ru/handle/20.500.12258/18098
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id	ir-20.500.12258-18098
record_format	dspace
spelling	ir-20.500.12258-180982021-09-10T07:06:55Z [3 + 2]-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor Aksenov, A. V. Аксенов, А. В. Arutiunov, N. A. Арутюнов, Н. А. Kirilov, N. K. Кирилов, Н. К. Aksenov, D. A. Аксенов, Д. А. Grishin, I. Y. Гришин, И. Ю. Aksenov, N. A. Аксенов, Н. А. Rubin, M. A. Рубин, М. А. Indolizines Pyrazolo[1,5-a]pyridines Indolizine 9db Anticancer agents Indolizines and pyrazolo[1,5-a]pyridines were prepared via [3 + 2]-cycloaddition of pyridinium ylides to 1-chloro-2-nitrostyrenes. The synthesized molecules were evaluated for antiproliferative activities against a BE(2)-C neuroblastoma cell line with several compounds decreasing the viability of cancer cells. Indolizine 9db showed higher potency than that of all-trans-retinoic acid, an approved cancer drug. Mechanistically, it was found to inhibit tubulin polymerization and it is thus proposed that the discovered chemistry can be exploited for the development of novel microtubule-targeting anticancer agents 2021-09-06T13:53:57Z 2021-09-06T13:53:57Z 2021 Статья Aksenov, A. V.; Arutiunov, N. A.; Kirilov, N. K.; Aksenov, D. A.; Grishin, I. Y.; Aksenov, N. A.; Wang, H.; Du, L.; Betancourt, T.; Pelly, S. C.; Kornienko, A.; Rubin, M. [3 + 2]-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor // Organic and Biomolecular Chemistry. - 2021. - Том 19. - Выпуск 33. - Стр.: 7234 - 7245 http://hdl.handle.net/20.500.12258/18098 en Organic and Biomolecular Chemistry application/pdf application/pdf Royal Society of Chemistry
institution	СКФУ
collection	Репозиторий
language	English
topic	Indolizines Pyrazolo[1,5-a]pyridines Indolizine 9db Anticancer agents
spellingShingle	Indolizines Pyrazolo[1,5-a]pyridines Indolizine 9db Anticancer agents Aksenov, A. V. Аксенов, А. В. Arutiunov, N. A. Арутюнов, Н. А. Kirilov, N. K. Кирилов, Н. К. Aksenov, D. A. Аксенов, Д. А. Grishin, I. Y. Гришин, И. Ю. Aksenov, N. A. Аксенов, Н. А. Rubin, M. A. Рубин, М. А. [3 + 2]-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor
description	Indolizines and pyrazolo[1,5-a]pyridines were prepared via [3 + 2]-cycloaddition of pyridinium ylides to 1-chloro-2-nitrostyrenes. The synthesized molecules were evaluated for antiproliferative activities against a BE(2)-C neuroblastoma cell line with several compounds decreasing the viability of cancer cells. Indolizine 9db showed higher potency than that of all-trans-retinoic acid, an approved cancer drug. Mechanistically, it was found to inhibit tubulin polymerization and it is thus proposed that the discovered chemistry can be exploited for the development of novel microtubule-targeting anticancer agents
format	Статья
author	Aksenov, A. V. Аксенов, А. В. Arutiunov, N. A. Арутюнов, Н. А. Kirilov, N. K. Кирилов, Н. К. Aksenov, D. A. Аксенов, Д. А. Grishin, I. Y. Гришин, И. Ю. Aksenov, N. A. Аксенов, Н. А. Rubin, M. A. Рубин, М. А.
author_facet	Aksenov, A. V. Аксенов, А. В. Arutiunov, N. A. Арутюнов, Н. А. Kirilov, N. K. Кирилов, Н. К. Aksenov, D. A. Аксенов, Д. А. Grishin, I. Y. Гришин, И. Ю. Aksenov, N. A. Аксенов, Н. А. Rubin, M. A. Рубин, М. А.
author_sort	Aksenov, A. V.
title	[3 + 2]-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor
title_short	[3 + 2]-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor
title_full	[3 + 2]-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor
title_fullStr	[3 + 2]-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor
title_full_unstemmed	[3 + 2]-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor
title_sort	[3 + 2]-annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor
publisher	Royal Society of Chemistry
publishDate	2021
url	https://dspace.ncfu.ru/handle/20.500.12258/18098
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[3 + 2]-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor

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