Synthesis and some properties of new 5-Hydroxy-2-[(hetarylthio)methyl]-4H-pyran-4-ones

The reaction of 2-thioxoazines with chlorokojic acid in the presence of KOH in DMF led to the formation of new hybrid molecules containing fragments of kojic acid and azaheterocycle linked by the SCH2 spacer. In silico prediction of bioavailability parameters was carried out, possible protein target...

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Главные авторы:	Dotsenko, V. V., Доценко, В. В., Aksenov, N. A., Аксенов, Н. А., Aksenova, I. V., Аксенова, И. В.
Формат:	Статья
Язык:	English
Опубликовано:	Pleiades journals 2021
Темы:	2-thioxo-1,2-dihydroquinoxalines 3-cyanopyridine-2(1H)-thiones Calculated biological activity Chlorokojic acid S-alkylation
Online-ссылка:	https://dspace.ncfu.ru/handle/20.500.12258/18258
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id	ir-20.500.12258-18258
record_format	dspace
spelling	ir-20.500.12258-182582025-02-12T13:13:41Z Synthesis and some properties of new 5-Hydroxy-2-[(hetarylthio)methyl]-4H-pyran-4-ones Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. 2-thioxo-1,2-dihydroquinoxalines 3-cyanopyridine-2(1H)-thiones Calculated biological activity Chlorokojic acid S-alkylation The reaction of 2-thioxoazines with chlorokojic acid in the presence of KOH in DMF led to the formation of new hybrid molecules containing fragments of kojic acid and azaheterocycle linked by the SCH2 spacer. In silico prediction of bioavailability parameters was carried out, possible protein targets were predicted by the protein ligand docking method. 2021-11-11T09:34:02Z 2021-11-11T09:34:02Z 2021 Статья Dotsenko, V. V., Guz, D. D., Tebiev, D. T., Kindop V. K., Aksenov N. A., Aksenova, I. V., Netreba, E. E. Synthesis and some properties of new 5-Hydroxy-2-[(hetarylthio)methyl]-4H-pyran-4-ones // Russian Journal of General Chemistry. - 2021. - Том 91. - Выпуск 9. - Стр.: 1629 - 1638. - DOI 10.1134/S107036322109005X http://hdl.handle.net/20.500.12258/18258 en Russian Journal of General Chemistry application/pdf application/pdf Pleiades journals
institution	СКФУ
collection	Репозиторий
language	English
topic	2-thioxo-1,2-dihydroquinoxalines 3-cyanopyridine-2(1H)-thiones Calculated biological activity Chlorokojic acid S-alkylation
spellingShingle	2-thioxo-1,2-dihydroquinoxalines 3-cyanopyridine-2(1H)-thiones Calculated biological activity Chlorokojic acid S-alkylation Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. Synthesis and some properties of new 5-Hydroxy-2-[(hetarylthio)methyl]-4H-pyran-4-ones
description	The reaction of 2-thioxoazines with chlorokojic acid in the presence of KOH in DMF led to the formation of new hybrid molecules containing fragments of kojic acid and azaheterocycle linked by the SCH2 spacer. In silico prediction of bioavailability parameters was carried out, possible protein targets were predicted by the protein ligand docking method.
format	Статья
author	Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В.
author_facet	Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В.
author_sort	Dotsenko, V. V.
title	Synthesis and some properties of new 5-Hydroxy-2-[(hetarylthio)methyl]-4H-pyran-4-ones
title_short	Synthesis and some properties of new 5-Hydroxy-2-[(hetarylthio)methyl]-4H-pyran-4-ones
title_full	Synthesis and some properties of new 5-Hydroxy-2-[(hetarylthio)methyl]-4H-pyran-4-ones
title_fullStr	Synthesis and some properties of new 5-Hydroxy-2-[(hetarylthio)methyl]-4H-pyran-4-ones
title_full_unstemmed	Synthesis and some properties of new 5-Hydroxy-2-[(hetarylthio)methyl]-4H-pyran-4-ones
title_sort	synthesis and some properties of new 5-hydroxy-2-[(hetarylthio)methyl]-4h-pyran-4-ones
publisher	Pleiades journals
publishDate	2021
url	https://dspace.ncfu.ru/handle/20.500.12258/18258
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Synthesis and some properties of new 5-Hydroxy-2-[(hetarylthio)methyl]-4H-pyran-4-ones

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