New 4-(2-Furyl)-1,4-dihydronicotinonitriles and 1,4,5,6-Tetrahydronicotinonitriles: synthesis, structure, and analgesic activity

A series of new hybrid molecules containing 2-furyl and partially saturated pyridine fragments was obtained based on the reaction of cyanothioacetamide with furfural and 1,3-dicarbonyl compounds. The resulting compounds were tested in vivo for analgesic activity (rats) in the orofacial trigeminal pa...

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Главные авторы:	Dotsenko, V. V., Доценко, В. В., Aksenov, N. A., Аксенов, Н. А., Aksenova, I. V., Аксенова, И. В.
Формат:	Статья
Язык:	English
Опубликовано:	Pleiades journals 2021
Темы:	1,4-dihydropyridines; Tetrahydropyridines Analgesics Nicotinonitriles Cyanothioacetamide
Online-ссылка:	https://dspace.ncfu.ru/handle/20.500.12258/18259
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id	ir-20.500.12258-18259
record_format	dspace
spelling	ir-20.500.12258-182592025-02-12T13:10:51Z New 4-(2-Furyl)-1,4-dihydronicotinonitriles and 1,4,5,6-Tetrahydronicotinonitriles: synthesis, structure, and analgesic activity Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. 1,4-dihydropyridines; Tetrahydropyridines Analgesics Nicotinonitriles Cyanothioacetamide A series of new hybrid molecules containing 2-furyl and partially saturated pyridine fragments was obtained based on the reaction of cyanothioacetamide with furfural and 1,3-dicarbonyl compounds. The resulting compounds were tested in vivo for analgesic activity (rats) in the orofacial trigeminal pain test. Some the tested compounds showed an antinociceptive effect, superior to that of the reference drug (metamizole sodium). 2021-11-11T09:48:30Z 2021-11-11T09:48:30Z 2021 Статья Krivokolysko, D. S., Dotsenko, V. V., Bibik, E. Y., Samokish, A. A., Venidiktova Y. S., Frolov K. A., Krivokolysko S. G., Vasilin V. K., Pankov A. A., Aksenov, N. A., Aksenova, I. V. New 4-(2-Furyl)-1,4-dihydronicotinonitriles and 1,4,5,6-Tetrahydronicotinonitriles: synthesis, structure, and analgesic activity // Russian Journal of General Chemistry. - 2021. - Том 91. - Выпуск 9. - Стр.: 1646 - 1660. - DOI 10.1134/S1070363221090073 http://hdl.handle.net/20.500.12258/18259 en Russian Journal of General Chemistry application/pdf application/pdf Pleiades journals
institution	СКФУ
collection	Репозиторий
language	English
topic	1,4-dihydropyridines; Tetrahydropyridines Analgesics Nicotinonitriles Cyanothioacetamide
spellingShingle	1,4-dihydropyridines; Tetrahydropyridines Analgesics Nicotinonitriles Cyanothioacetamide Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. New 4-(2-Furyl)-1,4-dihydronicotinonitriles and 1,4,5,6-Tetrahydronicotinonitriles: synthesis, structure, and analgesic activity
description	A series of new hybrid molecules containing 2-furyl and partially saturated pyridine fragments was obtained based on the reaction of cyanothioacetamide with furfural and 1,3-dicarbonyl compounds. The resulting compounds were tested in vivo for analgesic activity (rats) in the orofacial trigeminal pain test. Some the tested compounds showed an antinociceptive effect, superior to that of the reference drug (metamizole sodium).
format	Статья
author	Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В.
author_facet	Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В.
author_sort	Dotsenko, V. V.
title	New 4-(2-Furyl)-1,4-dihydronicotinonitriles and 1,4,5,6-Tetrahydronicotinonitriles: synthesis, structure, and analgesic activity
title_short	New 4-(2-Furyl)-1,4-dihydronicotinonitriles and 1,4,5,6-Tetrahydronicotinonitriles: synthesis, structure, and analgesic activity
title_full	New 4-(2-Furyl)-1,4-dihydronicotinonitriles and 1,4,5,6-Tetrahydronicotinonitriles: synthesis, structure, and analgesic activity
title_fullStr	New 4-(2-Furyl)-1,4-dihydronicotinonitriles and 1,4,5,6-Tetrahydronicotinonitriles: synthesis, structure, and analgesic activity
title_full_unstemmed	New 4-(2-Furyl)-1,4-dihydronicotinonitriles and 1,4,5,6-Tetrahydronicotinonitriles: synthesis, structure, and analgesic activity
title_sort	new 4-(2-furyl)-1,4-dihydronicotinonitriles and 1,4,5,6-tetrahydronicotinonitriles: synthesis, structure, and analgesic activity
publisher	Pleiades journals
publishDate	2021
url	https://dspace.ncfu.ru/handle/20.500.12258/18259
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New 4-(2-Furyl)-1,4-dihydronicotinonitriles and 1,4,5,6-Tetrahydronicotinonitriles: synthesis, structure, and analgesic activity

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