An efficient approach to 2-CF3-indoles based on ortho-nitrobenzaldehydes

The catalytic olefination reaction of 2-nitrobenzaldehydes with CF3 CCl3 afforded stereose-lectively trifluoromethylated ortho-nitrostyrenes in up to 88% yield. The reaction of these alkenes with pyrrolidine permits preparation of α-CF3-β-(2-nitroaryl) enamines. Subsequent one pot reduction of nitro...

Полное описание

Сохранить в:

Библиографические подробности
Главные авторы:	Abaev, V. T., Абаев, В. Т.
Формат:	Статья
Язык:	English
Опубликовано:	MDPI 2021
Темы:	Indole Reduction Catalytic olefination reaction CF3-group Fluorine Nitro group
Online-ссылка:	https://dspace.ncfu.ru/handle/20.500.12258/18555
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!

id	ir-20.500.12258-18555
record_format	dspace
spelling	ir-20.500.12258-185552025-03-06T12:16:02Z An efficient approach to 2-CF3-indoles based on ortho-nitrobenzaldehydes Abaev, V. T. Абаев, В. Т. Indole Reduction Catalytic olefination reaction CF3-group Fluorine Nitro group The catalytic olefination reaction of 2-nitrobenzaldehydes with CF3 CCl3 afforded stereose-lectively trifluoromethylated ortho-nitrostyrenes in up to 88% yield. The reaction of these alkenes with pyrrolidine permits preparation of α-CF3-β-(2-nitroaryl) enamines. Subsequent one pot reduction of nitro-group by Fe-AcOH-H2 O system initiated intramolecular cyclization to afford 2-CF3-indoles. Target products can be prepared in up to 85% yields. Broad synthetic scope of the reaction was shown as well as some followed up transformations of 2-CF3-indole. 2021-12-28T13:52:07Z 2021-12-28T13:52:07Z 2021 Статья Muzalevskiy, V. M., Sizova, Z. A., Abaev, V. T., Nenajdenko, V. G. An efficient approach to 2-CF3-indoles based on ortho-nitrobenzaldehydes // Molecules. - 2021. - Том 26. - Выпуск 23. - Номер статьи 7365. - DOI10.3390/molecules26237365 http://hdl.handle.net/20.500.12258/18555 en Molecules application/pdf application/pdf MDPI
institution	СКФУ
collection	Репозиторий
language	English
topic	Indole Reduction Catalytic olefination reaction CF3-group Fluorine Nitro group
spellingShingle	Indole Reduction Catalytic olefination reaction CF3-group Fluorine Nitro group Abaev, V. T. Абаев, В. Т. An efficient approach to 2-CF3-indoles based on ortho-nitrobenzaldehydes
description	The catalytic olefination reaction of 2-nitrobenzaldehydes with CF3 CCl3 afforded stereose-lectively trifluoromethylated ortho-nitrostyrenes in up to 88% yield. The reaction of these alkenes with pyrrolidine permits preparation of α-CF3-β-(2-nitroaryl) enamines. Subsequent one pot reduction of nitro-group by Fe-AcOH-H2 O system initiated intramolecular cyclization to afford 2-CF3-indoles. Target products can be prepared in up to 85% yields. Broad synthetic scope of the reaction was shown as well as some followed up transformations of 2-CF3-indole.
format	Статья
author	Abaev, V. T. Абаев, В. Т.
author_facet	Abaev, V. T. Абаев, В. Т.
author_sort	Abaev, V. T.
title	An efficient approach to 2-CF3-indoles based on ortho-nitrobenzaldehydes
title_short	An efficient approach to 2-CF3-indoles based on ortho-nitrobenzaldehydes
title_full	An efficient approach to 2-CF3-indoles based on ortho-nitrobenzaldehydes
title_fullStr	An efficient approach to 2-CF3-indoles based on ortho-nitrobenzaldehydes
title_full_unstemmed	An efficient approach to 2-CF3-indoles based on ortho-nitrobenzaldehydes
title_sort	efficient approach to 2-cf3-indoles based on ortho-nitrobenzaldehydes
publisher	MDPI
publishDate	2021
url	https://dspace.ncfu.ru/handle/20.500.12258/18555
work_keys_str_mv	AT abaevvt anefficientapproachto2cf3indolesbasedonorthonitrobenzaldehydes AT abaevvt anefficientapproachto2cf3indolesbasedonorthonitrobenzaldehydes AT abaevvt efficientapproachto2cf3indolesbasedonorthonitrobenzaldehydes AT abaevvt efficientapproachto2cf3indolesbasedonorthonitrobenzaldehydes
_version_	1842245846348857344

An efficient approach to 2-CF3-indoles based on ortho-nitrobenzaldehydes

Схожие документы