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Synthesis, structure, and analgesic activity of 4-(5-Cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic acids ethyl esters

Synthesis, structure, and analgesic activity of 4-(5-Cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic acids ethyl esters

A series of new hybrid molecules containing fragments of anestesin and4-(2-furyl)-1,4-dihydronicotinonitrile have been obtained starting fromdiketene, ethyl 4-aminobenzoate, cyanothioacetamide, and furfural. The obtainedcompounds have been investigated for the analgesic activity in vivo (rats) in th...

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मुख्य लेखकों: Dotsenko, V. V., Доценко, В. В., Aksenov, N. A., Аксенов, Н. А., Aksenova, I. V., Аксенова, И. В.
स्वरूप: Статья
भाषा:English
प्रकाशित: Pleiades journals 2022
विषय:
1,4-dihydropyridines
Analgesic activity
Anesthesin
Cyanothioacetamide
Nicotinonitriles
ऑनलाइन पहुंच:https://dspace.ncfu.ru/handle/20.500.12258/18606
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spelling ir-20.500.12258-186062022-02-21T08:15:24Z Synthesis, structure, and analgesic activity of 4-(5-Cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic acids ethyl esters Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. 1,4-dihydropyridines Analgesic activity Anesthesin Cyanothioacetamide Nicotinonitriles A series of new hybrid molecules containing fragments of anestesin and4-(2-furyl)-1,4-dihydronicotinonitrile have been obtained starting fromdiketene, ethyl 4-aminobenzoate, cyanothioacetamide, and furfural. The obtainedcompounds have been investigated for the analgesic activity in vivo (rats) in the orofacial trigeminal pain andacetic acid induced writhing tests. The compounds exhibiting analgesic effectsuperior to that of the reference drug (metamizole sodium) have been revealed.Molecular docking has been performed for the considered compounds with respectto a wide range of protein targets, including cyclooxygenases COX-1 andCOX-2. 2022-01-24T11:47:35Z 2022-01-24T11:47:35Z 2021 Статья Krivokolysko, D. S., Dotsenko, V. V., Bibik, E. Y., Myazina A. V., Krivokolysko S. G., Vasilin V. K., Pankov A. A., Aksenov, N. A., Aksenova, I. V. Synthesis, structure, and analgesic activity of 4-(5-Cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic acids ethyl esters // Russian Journal of General Chemistry. - 2021. - Том 91. - Выпуск 12. - Стр.: 2588 - 2605. - DOI10.1134/S1070363221120306 http://hdl.handle.net/20.500.12258/18606 en Russian Journal of General Chemistry application/pdf application/pdf Pleiades journals
institution СКФУ
collection Репозиторий
language English
topic 1,4-dihydropyridines
Analgesic activity
Anesthesin
Cyanothioacetamide
Nicotinonitriles
spellingShingle 1,4-dihydropyridines
Analgesic activity
Anesthesin
Cyanothioacetamide
Nicotinonitriles
Dotsenko, V. V.
Доценко, В. В.
Aksenov, N. A.
Аксенов, Н. А.
Aksenova, I. V.
Аксенова, И. В.
Synthesis, structure, and analgesic activity of 4-(5-Cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic acids ethyl esters
description A series of new hybrid molecules containing fragments of anestesin and4-(2-furyl)-1,4-dihydronicotinonitrile have been obtained starting fromdiketene, ethyl 4-aminobenzoate, cyanothioacetamide, and furfural. The obtainedcompounds have been investigated for the analgesic activity in vivo (rats) in the orofacial trigeminal pain andacetic acid induced writhing tests. The compounds exhibiting analgesic effectsuperior to that of the reference drug (metamizole sodium) have been revealed.Molecular docking has been performed for the considered compounds with respectto a wide range of protein targets, including cyclooxygenases COX-1 andCOX-2.
format Статья
author Dotsenko, V. V.
Доценко, В. В.
Aksenov, N. A.
Аксенов, Н. А.
Aksenova, I. V.
Аксенова, И. В.
author_facet Dotsenko, V. V.
Доценко, В. В.
Aksenov, N. A.
Аксенов, Н. А.
Aksenova, I. V.
Аксенова, И. В.
author_sort Dotsenko, V. V.
title Synthesis, structure, and analgesic activity of 4-(5-Cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic acids ethyl esters
title_short Synthesis, structure, and analgesic activity of 4-(5-Cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic acids ethyl esters
title_full Synthesis, structure, and analgesic activity of 4-(5-Cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic acids ethyl esters
title_fullStr Synthesis, structure, and analgesic activity of 4-(5-Cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic acids ethyl esters
title_full_unstemmed Synthesis, structure, and analgesic activity of 4-(5-Cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic acids ethyl esters
title_sort synthesis, structure, and analgesic activity of 4-(5-cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic acids ethyl esters
publisher Pleiades journals
publishDate 2022
url https://dspace.ncfu.ru/handle/20.500.12258/18606
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