Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic acids and evaluation of cytotoxic activity of the products

2-Aryl-2-(3-indolyl)acetohydroxamic acids demonstrate promising antitumor activity, but quickly metabolize in vivo via glucuronidation of hydroxamic acid residue. In an attempt to improve their pharmacokinetics, methyl esters were synthesized via a newly developed protocol for chemoselective mono-me...

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Главные авторы:	Aksenov, D. A., Аксенов, Д. А., Aksenov, A. V., Аксенов, А. В., Prityko, L. A., Притыко, Л. А., Aksenov, N. A., Аксенов, Н. А., Rubin, M. A., Рубин, М. А.
Формат:	Статья
Язык:	English
Опубликовано:	MDPI 2022
Темы:	Anti-cancer activity Hydroxamic acid Indoles Methylation
Online-ссылка:	https://dspace.ncfu.ru/handle/20.500.12258/18612
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!

id	ir-20.500.12258-18612
record_format	dspace
spelling	ir-20.500.12258-186122025-02-13T09:57:46Z Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic acids and evaluation of cytotoxic activity of the products Aksenov, D. A. Аксенов, Д. А. Aksenov, A. V. Аксенов, А. В. Prityko, L. A. Притыко, Л. А. Aksenov, N. A. Аксенов, Н. А. Rubin, M. A. Рубин, М. А. Anti-cancer activity Hydroxamic acid Indoles Methylation 2-Aryl-2-(3-indolyl)acetohydroxamic acids demonstrate promising antitumor activity, but quickly metabolize in vivo via glucuronidation of hydroxamic acid residue. In an attempt to improve their pharmacokinetics, methyl esters were synthesized via a newly developed protocol for chemoselective mono-methylation of hydroxamic acids. The cytotoxicity of these derivatives against the HeLa cell line was evaluated and found to be inferior compared to the parent lead compounds. 2022-02-01T07:16:19Z 2022-02-01T07:16:19Z 2022 Статья Aksenov, D. A., Aksenov, A. V., Prityko L. A., Aksenov, N. A., Frolova L. V., Rubin, M. A. Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic acids and evaluation of cytotoxic activity of the products // MolBank. - 2022. - Том 2022. - Выпуск 1. - Номер статьи M1307. - DOI10.3390/M1307 http://hdl.handle.net/20.500.12258/18612 en MolBank application/pdf application/pdf MDPI
institution	СКФУ
collection	Репозиторий
language	English
topic	Anti-cancer activity Hydroxamic acid Indoles Methylation
spellingShingle	Anti-cancer activity Hydroxamic acid Indoles Methylation Aksenov, D. A. Аксенов, Д. А. Aksenov, A. V. Аксенов, А. В. Prityko, L. A. Притыко, Л. А. Aksenov, N. A. Аксенов, Н. А. Rubin, M. A. Рубин, М. А. Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic acids and evaluation of cytotoxic activity of the products
description	2-Aryl-2-(3-indolyl)acetohydroxamic acids demonstrate promising antitumor activity, but quickly metabolize in vivo via glucuronidation of hydroxamic acid residue. In an attempt to improve their pharmacokinetics, methyl esters were synthesized via a newly developed protocol for chemoselective mono-methylation of hydroxamic acids. The cytotoxicity of these derivatives against the HeLa cell line was evaluated and found to be inferior compared to the parent lead compounds.
format	Статья
author	Aksenov, D. A. Аксенов, Д. А. Aksenov, A. V. Аксенов, А. В. Prityko, L. A. Притыко, Л. А. Aksenov, N. A. Аксенов, Н. А. Rubin, M. A. Рубин, М. А.
author_facet	Aksenov, D. A. Аксенов, Д. А. Aksenov, A. V. Аксенов, А. В. Prityko, L. A. Притыко, Л. А. Aksenov, N. A. Аксенов, Н. А. Rubin, M. A. Рубин, М. А.
author_sort	Aksenov, D. A.
title	Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic acids and evaluation of cytotoxic activity of the products
title_short	Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic acids and evaluation of cytotoxic activity of the products
title_full	Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic acids and evaluation of cytotoxic activity of the products
title_fullStr	Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic acids and evaluation of cytotoxic activity of the products
title_full_unstemmed	Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic acids and evaluation of cytotoxic activity of the products
title_sort	methylation of 2-aryl-2-(3-indolyl)acetohydroxamic acids and evaluation of cytotoxic activity of the products
publisher	MDPI
publishDate	2022
url	https://dspace.ncfu.ru/handle/20.500.12258/18612
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Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic acids and evaluation of cytotoxic activity of the products

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