Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic acids and evaluation of cytotoxic activity of the products

Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic acids and evaluation of cytotoxic activity of the products

2-Aryl-2-(3-indolyl)acetohydroxamic acids demonstrate promising antitumor activity, but quickly metabolize in vivo via glucuronidation of hydroxamic acid residue. In an attempt to improve their pharmacokinetics, methyl esters were synthesized via a newly developed protocol for chemoselective mono-me...

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Главные авторы:	Aksenov, D. A., Аксенов, Д. А., Aksenov, A. V., Аксенов, А. В., Prityko, L. A., Притыко, Л. А., Aksenov, N. A., Аксенов, Н. А., Rubin, M. A., Рубин, М. А.
Формат:	Статья
Язык:	English
Опубликовано:	MDPI 2022
Темы:	Anti-cancer activity Hydroxamic acid Indoles Methylation
Online-ссылка:	https://dspace.ncfu.ru/handle/20.500.12258/18612
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!

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