Electrophilically activated nitroalkanes in the synthesis of substituted 1,3,4-oxadiazoles from amino acid derivatives

Novel preparative approach for the synthesis of alkylamines with 1,3,4-oxadiazole heterocyclic substituent is described. This method is based on unusual cascade transformation involving formal (4+1) cyclocondensation of hydrazides of amino acids with nitroalkanes electrophilically activated in the p...

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Chi tiết về thư mục
Những tác giả chính:	Aksenov, A. V., Аксенов, А. В., Kirilov, N. K., Кирилов, Н. К., Aksenov, N. A., Аксенов, Н. А., Arutiunov, N. A., Арутюнов, Н. А., Aksenov, D. A., Аксенов, Д. А., Rubin, M. A., Рубин, М. А.
Định dạng:	Статья
Ngôn ngữ:	English
Được phát hành:	Springer 2022
Những chủ đề:	1,3,4-oxadiazoles 1,3,4-thiadiazoles Amino acids Brønsted acid catalysis Cascade reaction Nitroalkanes Nucleophilic cycloaddition Semicarbazides
Truy cập trực tuyến:	https://dspace.ncfu.ru/handle/20.500.12258/18827
Các nhãn:	Thêm thẻ Không có thẻ, Là người đầu tiên thẻ bản ghi này!

Miêu tả
Tóm tắt:	Novel preparative approach for the synthesis of alkylamines with 1,3,4-oxadiazole heterocyclic substituent is described. This method is based on unusual cascade transformation involving formal (4+1) cyclocondensation of hydrazides of amino acids with nitroalkanes electrophilically activated in the presence of polyphosphoric acid.

Electrophilically activated nitroalkanes in the synthesis of substituted 1,3,4-oxadiazoles from amino acid derivatives

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