Electrophilically activated nitroalkanes in the synthesis of substituted 1,3,4-oxadiazoles from amino acid derivatives
Novel preparative approach for the synthesis of alkylamines with 1,3,4-oxadiazole heterocyclic substituent is described. This method is based on unusual cascade transformation involving formal (4+1) cyclocondensation of hydrazides of amino acids with nitroalkanes electrophilically activated in the p...
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2022
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ir-20.500.12258-188272025-02-13T09:51:13Z Electrophilically activated nitroalkanes in the synthesis of substituted 1,3,4-oxadiazoles from amino acid derivatives Aksenov, A. V. Аксенов, А. В. Kirilov, N. K. Кирилов, Н. К. Aksenov, N. A. Аксенов, Н. А. Arutiunov, N. A. Арутюнов, Н. А. Aksenov, D. A. Аксенов, Д. А. Rubin, M. A. Рубин, М. А. 1,3,4-oxadiazoles 1,3,4-thiadiazoles Amino acids Brønsted acid catalysis Cascade reaction Nitroalkanes Nucleophilic cycloaddition Semicarbazides Novel preparative approach for the synthesis of alkylamines with 1,3,4-oxadiazole heterocyclic substituent is described. This method is based on unusual cascade transformation involving formal (4+1) cyclocondensation of hydrazides of amino acids with nitroalkanes electrophilically activated in the presence of polyphosphoric acid. 2022-02-14T08:53:05Z 2022-02-14T08:53:05Z 2022 Статья Aksenov, A. V., Kirilov, N. K., Aksenov, N. A., Arutiunov, N. A., Aksenov, D. A., Rubin, M. A. Electrophilically activated nitroalkanes in the synthesis of substituted 1,3,4-oxadiazoles from amino acid derivatives // Chemistry of Heterocyclic Compounds. - 2022. - DOI10.1007/s10593-022-03053-2 http://hdl.handle.net/20.500.12258/18827 en Chemistry of Heterocyclic Compounds application/pdf application/pdf Springer |
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Репозиторий |
| language |
English |
| topic |
1,3,4-oxadiazoles 1,3,4-thiadiazoles Amino acids Brønsted acid catalysis Cascade reaction Nitroalkanes Nucleophilic cycloaddition Semicarbazides |
| spellingShingle |
1,3,4-oxadiazoles 1,3,4-thiadiazoles Amino acids Brønsted acid catalysis Cascade reaction Nitroalkanes Nucleophilic cycloaddition Semicarbazides Aksenov, A. V. Аксенов, А. В. Kirilov, N. K. Кирилов, Н. К. Aksenov, N. A. Аксенов, Н. А. Arutiunov, N. A. Арутюнов, Н. А. Aksenov, D. A. Аксенов, Д. А. Rubin, M. A. Рубин, М. А. Electrophilically activated nitroalkanes in the synthesis of substituted 1,3,4-oxadiazoles from amino acid derivatives |
| description |
Novel preparative approach for the synthesis of alkylamines with 1,3,4-oxadiazole heterocyclic substituent is described. This method is based on unusual cascade transformation involving formal (4+1) cyclocondensation of hydrazides of amino acids with nitroalkanes electrophilically activated in the presence of polyphosphoric acid. |
| format |
Статья |
| author |
Aksenov, A. V. Аксенов, А. В. Kirilov, N. K. Кирилов, Н. К. Aksenov, N. A. Аксенов, Н. А. Arutiunov, N. A. Арутюнов, Н. А. Aksenov, D. A. Аксенов, Д. А. Rubin, M. A. Рубин, М. А. |
| author_facet |
Aksenov, A. V. Аксенов, А. В. Kirilov, N. K. Кирилов, Н. К. Aksenov, N. A. Аксенов, Н. А. Arutiunov, N. A. Арутюнов, Н. А. Aksenov, D. A. Аксенов, Д. А. Rubin, M. A. Рубин, М. А. |
| author_sort |
Aksenov, A. V. |
| title |
Electrophilically activated nitroalkanes in the synthesis of substituted 1,3,4-oxadiazoles from amino acid derivatives |
| title_short |
Electrophilically activated nitroalkanes in the synthesis of substituted 1,3,4-oxadiazoles from amino acid derivatives |
| title_full |
Electrophilically activated nitroalkanes in the synthesis of substituted 1,3,4-oxadiazoles from amino acid derivatives |
| title_fullStr |
Electrophilically activated nitroalkanes in the synthesis of substituted 1,3,4-oxadiazoles from amino acid derivatives |
| title_full_unstemmed |
Electrophilically activated nitroalkanes in the synthesis of substituted 1,3,4-oxadiazoles from amino acid derivatives |
| title_sort |
electrophilically activated nitroalkanes in the synthesis of substituted 1,3,4-oxadiazoles from amino acid derivatives |
| publisher |
Springer |
| publishDate |
2022 |
| url |
https://dspace.ncfu.ru/handle/20.500.12258/18827 |
| work_keys_str_mv |
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