Investigation of cationic transformations involving 5-ethynyl-4-arylpyrimidines

An innovative synthetic approach towards 5-ethynyl-4-arylpyrimidines was developed involving acid-catalyzed electrophilic alkylation of phenols with 5-bromopyrimidine, followed by oxidation and palladium-catalyzed Sonogashira cross-coupling reaction. Reactions of these compounds in the presence of t...

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Главные авторы:	Shcherbakov, S. V., Щербаков, С. В., Magometov, A. Y., Магометов, А. Ю., Vendin, M. V., Вендин, М. В., Shcherbakova, V. Y., Щербакова, В. Ю., Aksenov, N. A., Аксенов, Н. А., Aksenov, A. V., Аксенов, А. В., Rubin, M. A., Рубин, М. А.
Формат:	Статья
Язык:	English
Опубликовано:	Elsevier Ltd 2022
Темы:	Acetylenes Cationic rearrangements Heterocyclic chemistry Reaction mechanisms Synthetic methodology
Online-ссылка:	https://dspace.ncfu.ru/handle/20.500.12258/19633
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spelling	ir-20.500.12258-196332025-02-13T09:46:34Z Investigation of cationic transformations involving 5-ethynyl-4-arylpyrimidines Shcherbakov, S. V. Щербаков, С. В. Magometov, A. Y. Магометов, А. Ю. Vendin, M. V. Вендин, М. В. Shcherbakova, V. Y. Щербакова, В. Ю. Aksenov, N. A. Аксенов, Н. А. Aksenov, A. V. Аксенов, А. В. Rubin, M. A. Рубин, М. А. Acetylenes Cationic rearrangements Heterocyclic chemistry Reaction mechanisms Synthetic methodology An innovative synthetic approach towards 5-ethynyl-4-arylpyrimidines was developed involving acid-catalyzed electrophilic alkylation of phenols with 5-bromopyrimidine, followed by oxidation and palladium-catalyzed Sonogashira cross-coupling reaction. Reactions of these compounds in the presence of trifluoromethanesulfonic acid were investigated. It was discovered these reactions take a different route for precursors with a different position of phenol group in an arene substituent. 2022-05-27T11:54:53Z 2022-05-27T11:54:53Z 2022 Статья Shcherbakov, S. V., Magometov, A. Y., Vendin, M. V., Shcherbakova, V. Y., Aksenov, N. A., Aksenov, A. V., Naji, O., Rubin, M. Investigation of cationic transformations involving 5-ethynyl-4-arylpyrimidines // Tetrahedron. - 2022. - Номер статьи 132796. - DOI10.1016/j.tet.2022.132796 http://hdl.handle.net/20.500.12258/19633 en Tetrahedron application/pdf Elsevier Ltd
institution	СКФУ
collection	Репозиторий
language	English
topic	Acetylenes Cationic rearrangements Heterocyclic chemistry Reaction mechanisms Synthetic methodology
spellingShingle	Acetylenes Cationic rearrangements Heterocyclic chemistry Reaction mechanisms Synthetic methodology Shcherbakov, S. V. Щербаков, С. В. Magometov, A. Y. Магометов, А. Ю. Vendin, M. V. Вендин, М. В. Shcherbakova, V. Y. Щербакова, В. Ю. Aksenov, N. A. Аксенов, Н. А. Aksenov, A. V. Аксенов, А. В. Rubin, M. A. Рубин, М. А. Investigation of cationic transformations involving 5-ethynyl-4-arylpyrimidines
description	An innovative synthetic approach towards 5-ethynyl-4-arylpyrimidines was developed involving acid-catalyzed electrophilic alkylation of phenols with 5-bromopyrimidine, followed by oxidation and palladium-catalyzed Sonogashira cross-coupling reaction. Reactions of these compounds in the presence of trifluoromethanesulfonic acid were investigated. It was discovered these reactions take a different route for precursors with a different position of phenol group in an arene substituent.
format	Статья
author	Shcherbakov, S. V. Щербаков, С. В. Magometov, A. Y. Магометов, А. Ю. Vendin, M. V. Вендин, М. В. Shcherbakova, V. Y. Щербакова, В. Ю. Aksenov, N. A. Аксенов, Н. А. Aksenov, A. V. Аксенов, А. В. Rubin, M. A. Рубин, М. А.
author_facet	Shcherbakov, S. V. Щербаков, С. В. Magometov, A. Y. Магометов, А. Ю. Vendin, M. V. Вендин, М. В. Shcherbakova, V. Y. Щербакова, В. Ю. Aksenov, N. A. Аксенов, Н. А. Aksenov, A. V. Аксенов, А. В. Rubin, M. A. Рубин, М. А.
author_sort	Shcherbakov, S. V.
title	Investigation of cationic transformations involving 5-ethynyl-4-arylpyrimidines
title_short	Investigation of cationic transformations involving 5-ethynyl-4-arylpyrimidines
title_full	Investigation of cationic transformations involving 5-ethynyl-4-arylpyrimidines
title_fullStr	Investigation of cationic transformations involving 5-ethynyl-4-arylpyrimidines
title_full_unstemmed	Investigation of cationic transformations involving 5-ethynyl-4-arylpyrimidines
title_sort	investigation of cationic transformations involving 5-ethynyl-4-arylpyrimidines
publisher	Elsevier Ltd
publishDate	2022
url	https://dspace.ncfu.ru/handle/20.500.12258/19633
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Investigation of cationic transformations involving 5-ethynyl-4-arylpyrimidines

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