New Hybrid Molecules Based on Sulfur-Containing Nicotinonitriles: Synthesis, Analgesic Activity in Acetic Acid-Induced Writhing Test, and Molecular Docking Studies

New hybrid molecules bearing furyl and 1,4-dihydronicotinonitrile (or 1,4,5,6-tetrahydronicotinonitrile) fragments have been prepared. The analgesic activity was studied in vivo (rats) in acetic acid-induced writhing test. Some compounds showed activity exceeding that of the reference compound (meta...

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Κύριοι συγγραφείς:	Dotsenko, V. V., Доценко, В. В., Aksenov, N. A., Аксенов, Н. А., Aksenova, I. V., Аксенова, И. В.
Μορφή:	Статья
Γλώσσα:	English
Έκδοση:	Pleiades journals 2022
Θέματα:	1,4,5,6-tetrahydropyridines 1,4-dihydropyridines Analgesics Molecular docking Nicotinonitriles
Διαθέσιμο Online:	https://dspace.ncfu.ru/handle/20.500.12258/21197
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spelling	ir-20.500.12258-211972022-09-15T08:39:53Z New Hybrid Molecules Based on Sulfur-Containing Nicotinonitriles: Synthesis, Analgesic Activity in Acetic Acid-Induced Writhing Test, and Molecular Docking Studies Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. 1,4,5,6-tetrahydropyridines 1,4-dihydropyridines Analgesics Molecular docking Nicotinonitriles New hybrid molecules bearing furyl and 1,4-dihydronicotinonitrile (or 1,4,5,6-tetrahydronicotinonitrile) fragments have been prepared. The analgesic activity was studied in vivo (rats) in acetic acid-induced writhing test. Some compounds showed activity exceeding that of the reference compound (metamizole). Molecular docking was performed with all the compounds against COX-1 and COX-2. Also, we performed the docking studies in order to find new possible protein targets. 2022-09-15T08:38:58Z 2022-09-15T08:38:58Z 2022 Статья Krivokolysko, D. S., Dotsenko, V. V., Bibik, E. Y., Samokish, A. A., Venidiktova, Y. S., Frolov, K. A., Krivokolysko, S. G., Pankov, A. A., Aksenov, N. A., Aksenova, I. V. New Hybrid Molecules Based on Sulfur-Containing Nicotinonitriles: Synthesis, Analgesic Activity in Acetic Acid-Induced Writhing Test, and Molecular Docking Studies. - Russian Journal of Bioorganic Chemistry. - 2022. - Том 48. - Выпуск 3. - Страницы 628 - 635. - DOI10.1134/S1068162022030104 http://hdl.handle.net/20.500.12258/21197 en Russian Journal of Bioorganic Chemistry application/pdf application/pdf Pleiades journals
institution	СКФУ
collection	Репозиторий
language	English
topic	1,4,5,6-tetrahydropyridines 1,4-dihydropyridines Analgesics Molecular docking Nicotinonitriles
spellingShingle	1,4,5,6-tetrahydropyridines 1,4-dihydropyridines Analgesics Molecular docking Nicotinonitriles Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. New Hybrid Molecules Based on Sulfur-Containing Nicotinonitriles: Synthesis, Analgesic Activity in Acetic Acid-Induced Writhing Test, and Molecular Docking Studies
description	New hybrid molecules bearing furyl and 1,4-dihydronicotinonitrile (or 1,4,5,6-tetrahydronicotinonitrile) fragments have been prepared. The analgesic activity was studied in vivo (rats) in acetic acid-induced writhing test. Some compounds showed activity exceeding that of the reference compound (metamizole). Molecular docking was performed with all the compounds against COX-1 and COX-2. Also, we performed the docking studies in order to find new possible protein targets.
format	Статья
author	Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В.
author_facet	Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В.
author_sort	Dotsenko, V. V.
title	New Hybrid Molecules Based on Sulfur-Containing Nicotinonitriles: Synthesis, Analgesic Activity in Acetic Acid-Induced Writhing Test, and Molecular Docking Studies
title_short	New Hybrid Molecules Based on Sulfur-Containing Nicotinonitriles: Synthesis, Analgesic Activity in Acetic Acid-Induced Writhing Test, and Molecular Docking Studies
title_full	New Hybrid Molecules Based on Sulfur-Containing Nicotinonitriles: Synthesis, Analgesic Activity in Acetic Acid-Induced Writhing Test, and Molecular Docking Studies
title_fullStr	New Hybrid Molecules Based on Sulfur-Containing Nicotinonitriles: Synthesis, Analgesic Activity in Acetic Acid-Induced Writhing Test, and Molecular Docking Studies
title_full_unstemmed	New Hybrid Molecules Based on Sulfur-Containing Nicotinonitriles: Synthesis, Analgesic Activity in Acetic Acid-Induced Writhing Test, and Molecular Docking Studies
title_sort	new hybrid molecules based on sulfur-containing nicotinonitriles: synthesis, analgesic activity in acetic acid-induced writhing test, and molecular docking studies
publisher	Pleiades journals
publishDate	2022
url	https://dspace.ncfu.ru/handle/20.500.12258/21197
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New Hybrid Molecules Based on Sulfur-Containing Nicotinonitriles: Synthesis, Analgesic Activity in Acetic Acid-Induced Writhing Test, and Molecular Docking Studies

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