Oxidation of 2-Cyanothioacrylamides with Sodium Nitrite in Acidic Medium

(E)-3-Aryl-2-cyanoprop-2-entioamides, prepared by Knoevenagel condensation between aromatic aldehydes and cyanothioacetamide, react with sodium nitrite in acetic acid to form (2E,2′E)-2,2′-(1,2,4-thiadiazole-3,5-diyl)bis[3-arylacrylonitriles]. A possible mechanism and limitations of the reaction are...

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Главные авторы:	Dotsenko, V. V., Доценко, В. В., Aksenov, N. A., Аксенов, Н. А., Aksenova, I. V., Аксенова, И. В., Likhovid, N. G., Лиховид, Н. Г.
Формат:	Статья
Язык:	English
Опубликовано:	Pleiades journals 2022
Темы:	1,2,4-thiadiazoles 2-cyanothioacrylamides Cyanothioacetamide Oxidative dimerization Thioamides
Online-ссылка:	https://dspace.ncfu.ru/handle/20.500.12258/21940
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spelling	ir-20.500.12258-219402025-02-13T10:06:10Z Oxidation of 2-Cyanothioacrylamides with Sodium Nitrite in Acidic Medium Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. Likhovid, N. G. Лиховид, Н. Г. 1,2,4-thiadiazoles 2-cyanothioacrylamides Cyanothioacetamide Oxidative dimerization Thioamides (E)-3-Aryl-2-cyanoprop-2-entioamides, prepared by Knoevenagel condensation between aromatic aldehydes and cyanothioacetamide, react with sodium nitrite in acetic acid to form (2E,2′E)-2,2′-(1,2,4-thiadiazole-3,5-diyl)bis[3-arylacrylonitriles]. A possible mechanism and limitations of the reaction are discussed. Molecular docking was carried out in order to search for possible protein targets for the obtained 1,2,4-thiadiazoles. One of the compounds showed a pronounced antidote effect against the herbicide 2,4-D in a laboratory experiment on sunflower seedlings and under field conditions. 2022-12-07T07:41:00Z 2022-12-07T07:41:00Z 2022 Статья Dahno, P.G., Zhilyaev, D.M., Dotsenko, V.V., Strelkov, V.D., Krapivin, G.D., Aksenov, N.A., Aksenova, I.V., Likhovid, N.G. Oxidation of 2-Cyanothioacrylamides with Sodium Nitrite in Acidic Medium // Russian Journal of General Chemistry. - 2022. - Volume 92. - Issue 9. - Pages 1667-1676. - DOI10.1134/S1070363222090080 http://hdl.handle.net/20.500.12258/21940 en Russian Journal of General Chemistry application/pdf application/pdf Pleiades journals
institution	СКФУ
collection	Репозиторий
language	English
topic	1,2,4-thiadiazoles 2-cyanothioacrylamides Cyanothioacetamide Oxidative dimerization Thioamides
spellingShingle	1,2,4-thiadiazoles 2-cyanothioacrylamides Cyanothioacetamide Oxidative dimerization Thioamides Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. Likhovid, N. G. Лиховид, Н. Г. Oxidation of 2-Cyanothioacrylamides with Sodium Nitrite in Acidic Medium
description	(E)-3-Aryl-2-cyanoprop-2-entioamides, prepared by Knoevenagel condensation between aromatic aldehydes and cyanothioacetamide, react with sodium nitrite in acetic acid to form (2E,2′E)-2,2′-(1,2,4-thiadiazole-3,5-diyl)bis[3-arylacrylonitriles]. A possible mechanism and limitations of the reaction are discussed. Molecular docking was carried out in order to search for possible protein targets for the obtained 1,2,4-thiadiazoles. One of the compounds showed a pronounced antidote effect against the herbicide 2,4-D in a laboratory experiment on sunflower seedlings and under field conditions.
format	Статья
author	Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. Likhovid, N. G. Лиховид, Н. Г.
author_facet	Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. Likhovid, N. G. Лиховид, Н. Г.
author_sort	Dotsenko, V. V.
title	Oxidation of 2-Cyanothioacrylamides with Sodium Nitrite in Acidic Medium
title_short	Oxidation of 2-Cyanothioacrylamides with Sodium Nitrite in Acidic Medium
title_full	Oxidation of 2-Cyanothioacrylamides with Sodium Nitrite in Acidic Medium
title_fullStr	Oxidation of 2-Cyanothioacrylamides with Sodium Nitrite in Acidic Medium
title_full_unstemmed	Oxidation of 2-Cyanothioacrylamides with Sodium Nitrite in Acidic Medium
title_sort	oxidation of 2-cyanothioacrylamides with sodium nitrite in acidic medium
publisher	Pleiades journals
publishDate	2022
url	https://dspace.ncfu.ru/handle/20.500.12258/21940
work_keys_str_mv	AT dotsenkovv oxidationof2cyanothioacrylamideswithsodiumnitriteinacidicmedium AT docenkovv oxidationof2cyanothioacrylamideswithsodiumnitriteinacidicmedium AT aksenovna oxidationof2cyanothioacrylamideswithsodiumnitriteinacidicmedium AT aksenovna oxidationof2cyanothioacrylamideswithsodiumnitriteinacidicmedium AT aksenovaiv oxidationof2cyanothioacrylamideswithsodiumnitriteinacidicmedium AT aksenovaiv oxidationof2cyanothioacrylamideswithsodiumnitriteinacidicmedium AT likhovidng oxidationof2cyanothioacrylamideswithsodiumnitriteinacidicmedium AT lihovidng oxidationof2cyanothioacrylamideswithsodiumnitriteinacidicmedium
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Oxidation of 2-Cyanothioacrylamides with Sodium Nitrite in Acidic Medium

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