Prospects of Testing Diurnal Profiles of Expressions of TSH-R and Circadian Clock Genes in Thyrocytes for Identification of Preoperative Biomarkers for Thyroid Carcinoma

Thyroid Nodules (TN) are frequent but mostly benign, and postoperative rate of benign TN attains the values from 70% to 90%. Therefore, there is an urgent need for identification of reliable preoperative diagnosis markers for patients with indeterminate thyroid cytology. In this study, an earlier un...

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Asıl Yazarlar:	Putilov, A. A., Путилов, А. А.
Materyal Türü:	Статья
Dil:	English
Baskı/Yayın Bilgisi:	MDPI 2022
Konular:	Circadian clock genes Circadian clockwork Thyroid cancer Thyroid nodules TSH TSH-R
Online Erişim:	https://dspace.ncfu.ru/handle/20.500.12258/21953
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id	ir-20.500.12258-21953
record_format	dspace
spelling	ir-20.500.12258-219532022-12-07T12:50:00Z Prospects of Testing Diurnal Profiles of Expressions of TSH-R and Circadian Clock Genes in Thyrocytes for Identification of Preoperative Biomarkers for Thyroid Carcinoma Putilov, A. A. Путилов, А. А. Circadian clock genes Circadian clockwork Thyroid cancer Thyroid nodules TSH TSH-R Thyroid Nodules (TN) are frequent but mostly benign, and postoperative rate of benign TN attains the values from 70% to 90%. Therefore, there is an urgent need for identification of reliable preoperative diagnosis markers for patients with indeterminate thyroid cytology. In this study, an earlier unexplored design of research on preoperative biomarkers for thyroid malignancies was proposed. Evaluation of reported results of studies addressing the links of thyroid cancer to the circadian clockwork dysfunctions and abnormal activities of Thyroid-Stimulating Hormone (TSH) and its receptor (TSH-R) suggested diagnostic significance of such links. However, there is still a gap in studies of interrelationships between diurnal profiles of expression of circadian clock genes and TSH-R in indeterminate thyroid tissue exposed to different concentrations of TSH. These interrelationships might be investigated in future in vitro experiments on benign and malignant thyrocytes cultivated under normal and challenged TSH levels. Their design requires simultaneous measurement of diurnal profiles of expression of both circadian clock genes and TSH-R. Experimental results might help to bridge previous studies of preoperative biomarkers for thyroid carcinoma exploring diagnostic value of diurnal profiles of serum TSH levels, expression of TSH-R, and expression of circadian clock genes. 2022-12-07T12:46:52Z 2022-12-07T12:46:52Z 2022 Статья Putilov, A. Prospects of Testing Diurnal Profiles of Expressions of TSH-R and Circadian Clock Genes in Thyrocytes for Identification of Preoperative Biomarkers for Thyroid Carcinoma // International Journal of Molecular Sciences. - 2022. - Volume 23. - Issue 20. - Номер статьи 12208. - DOI10.3390/ijms232012208 http://hdl.handle.net/20.500.12258/21953 en International Journal of Molecular Sciences application/pdf application/pdf MDPI
institution	СКФУ
collection	Репозиторий
language	English
topic	Circadian clock genes Circadian clockwork Thyroid cancer Thyroid nodules TSH TSH-R
spellingShingle	Circadian clock genes Circadian clockwork Thyroid cancer Thyroid nodules TSH TSH-R Putilov, A. A. Путилов, А. А. Prospects of Testing Diurnal Profiles of Expressions of TSH-R and Circadian Clock Genes in Thyrocytes for Identification of Preoperative Biomarkers for Thyroid Carcinoma
description	Thyroid Nodules (TN) are frequent but mostly benign, and postoperative rate of benign TN attains the values from 70% to 90%. Therefore, there is an urgent need for identification of reliable preoperative diagnosis markers for patients with indeterminate thyroid cytology. In this study, an earlier unexplored design of research on preoperative biomarkers for thyroid malignancies was proposed. Evaluation of reported results of studies addressing the links of thyroid cancer to the circadian clockwork dysfunctions and abnormal activities of Thyroid-Stimulating Hormone (TSH) and its receptor (TSH-R) suggested diagnostic significance of such links. However, there is still a gap in studies of interrelationships between diurnal profiles of expression of circadian clock genes and TSH-R in indeterminate thyroid tissue exposed to different concentrations of TSH. These interrelationships might be investigated in future in vitro experiments on benign and malignant thyrocytes cultivated under normal and challenged TSH levels. Their design requires simultaneous measurement of diurnal profiles of expression of both circadian clock genes and TSH-R. Experimental results might help to bridge previous studies of preoperative biomarkers for thyroid carcinoma exploring diagnostic value of diurnal profiles of serum TSH levels, expression of TSH-R, and expression of circadian clock genes.
format	Статья
author	Putilov, A. A. Путилов, А. А.
author_facet	Putilov, A. A. Путилов, А. А.
author_sort	Putilov, A. A.
title	Prospects of Testing Diurnal Profiles of Expressions of TSH-R and Circadian Clock Genes in Thyrocytes for Identification of Preoperative Biomarkers for Thyroid Carcinoma
title_short	Prospects of Testing Diurnal Profiles of Expressions of TSH-R and Circadian Clock Genes in Thyrocytes for Identification of Preoperative Biomarkers for Thyroid Carcinoma
title_full	Prospects of Testing Diurnal Profiles of Expressions of TSH-R and Circadian Clock Genes in Thyrocytes for Identification of Preoperative Biomarkers for Thyroid Carcinoma
title_fullStr	Prospects of Testing Diurnal Profiles of Expressions of TSH-R and Circadian Clock Genes in Thyrocytes for Identification of Preoperative Biomarkers for Thyroid Carcinoma
title_full_unstemmed	Prospects of Testing Diurnal Profiles of Expressions of TSH-R and Circadian Clock Genes in Thyrocytes for Identification of Preoperative Biomarkers for Thyroid Carcinoma
title_sort	prospects of testing diurnal profiles of expressions of tsh-r and circadian clock genes in thyrocytes for identification of preoperative biomarkers for thyroid carcinoma
publisher	MDPI
publishDate	2022
url	https://dspace.ncfu.ru/handle/20.500.12258/21953
work_keys_str_mv	AT putilovaa prospectsoftestingdiurnalprofilesofexpressionsoftshrandcircadianclockgenesinthyrocytesforidentificationofpreoperativebiomarkersforthyroidcarcinoma AT putilovaa prospectsoftestingdiurnalprofilesofexpressionsoftshrandcircadianclockgenesinthyrocytesforidentificationofpreoperativebiomarkersforthyroidcarcinoma
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Prospects of Testing Diurnal Profiles of Expressions of TSH-R and Circadian Clock Genes in Thyrocytes for Identification of Preoperative Biomarkers for Thyroid Carcinoma

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