Reductive Cleavage of 4′ H-Spiro[indole-3,5′-isoxazoles] en Route to 2-(1 H-Indol-3-yl)acetamides with Anticancer Activities

Unusual cascade transformation involving ring opening and 1,2-alkyl shift was observed upon the reduction of 4′H-spiro[indole-3,5′-isoxazoles] or 2-(3-oxoindolin-2-yl)acetonitriles with sodium borohydride. This reaction allowed for expeditious and highly efficient preparation of 2-(1H-Indol-3-yl)ace...

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Prif Awduron:	Aksenov, A. V., Аксенов, А. В., Kirilov, N. K., Кирилов, Н. К., Arutiunov, N. A., Арутюнов, Н. А., Aksenov, D. A., Аксенов, Д. А., Kuzminov, I. K., Кузьминов, И. К., Aksenov, N. A., Аксенов, Н. А., Rubin, M. A., Рубин, М. А.
Fformat:	Статья
Iaith:	English
Cyhoeddwyd:	American Chemical Society 2022
Pynciau:	Polycyclic aromatic hydrocarbons Sodium Borohydride
Mynediad Ar-lein:	https://dspace.ncfu.ru/handle/20.500.12258/21960
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

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spelling	ir-20.500.12258-219602022-12-08T08:30:23Z Reductive Cleavage of 4′ H-Spiro[indole-3,5′-isoxazoles] en Route to 2-(1 H-Indol-3-yl)acetamides with Anticancer Activities Aksenov, A. V. Аксенов, А. В. Kirilov, N. K. Кирилов, Н. К. Arutiunov, N. A. Арутюнов, Н. А. Aksenov, D. A. Аксенов, Д. А. Kuzminov, I. K. Кузьминов, И. К. Aksenov, N. A. Аксенов, Н. А. Rubin, M. A. Рубин, М. А. Polycyclic aromatic hydrocarbons Sodium Borohydride Unusual cascade transformation involving ring opening and 1,2-alkyl shift was observed upon the reduction of 4′H-spiro[indole-3,5′-isoxazoles] or 2-(3-oxoindolin-2-yl)acetonitriles with sodium borohydride. This reaction allowed for expeditious and highly efficient preparation of 2-(1H-Indol-3-yl)acetamides with antiproliferative properties. 2022-12-08T08:29:45Z 2022-12-08T08:29:45Z 2022 Статья Aksenov, A.V., Kirilov, N.K., Arutiunov, N.A., Aksenov, D.A., Kuzminov, I.K., Aksenov, N.A., Turner, D.N., Rogelj, S., Kornienko, A., Rubin, M. Reductive Cleavage of 4′ H-Spiro[indole-3,5′-isoxazoles] en Route to 2-(1 H-Indol-3-yl)acetamides with Anticancer Activities // Journal of Organic Chemistry. - 2022. - Volume 87. - Issue 21. - Pages 13955-13964. - DOI10.1021/acs.joc.2c01627 http://hdl.handle.net/20.500.12258/21960 en Journal of Organic Chemistry application/pdf application/pdf American Chemical Society
institution	СКФУ
collection	Репозиторий
language	English
topic	Polycyclic aromatic hydrocarbons Sodium Borohydride
spellingShingle	Polycyclic aromatic hydrocarbons Sodium Borohydride Aksenov, A. V. Аксенов, А. В. Kirilov, N. K. Кирилов, Н. К. Arutiunov, N. A. Арутюнов, Н. А. Aksenov, D. A. Аксенов, Д. А. Kuzminov, I. K. Кузьминов, И. К. Aksenov, N. A. Аксенов, Н. А. Rubin, M. A. Рубин, М. А. Reductive Cleavage of 4′ H-Spiro[indole-3,5′-isoxazoles] en Route to 2-(1 H-Indol-3-yl)acetamides with Anticancer Activities
description	Unusual cascade transformation involving ring opening and 1,2-alkyl shift was observed upon the reduction of 4′H-spiro[indole-3,5′-isoxazoles] or 2-(3-oxoindolin-2-yl)acetonitriles with sodium borohydride. This reaction allowed for expeditious and highly efficient preparation of 2-(1H-Indol-3-yl)acetamides with antiproliferative properties.
format	Статья
author	Aksenov, A. V. Аксенов, А. В. Kirilov, N. K. Кирилов, Н. К. Arutiunov, N. A. Арутюнов, Н. А. Aksenov, D. A. Аксенов, Д. А. Kuzminov, I. K. Кузьминов, И. К. Aksenov, N. A. Аксенов, Н. А. Rubin, M. A. Рубин, М. А.
author_facet	Aksenov, A. V. Аксенов, А. В. Kirilov, N. K. Кирилов, Н. К. Arutiunov, N. A. Арутюнов, Н. А. Aksenov, D. A. Аксенов, Д. А. Kuzminov, I. K. Кузьминов, И. К. Aksenov, N. A. Аксенов, Н. А. Rubin, M. A. Рубин, М. А.
author_sort	Aksenov, A. V.
title	Reductive Cleavage of 4′ H-Spiro[indole-3,5′-isoxazoles] en Route to 2-(1 H-Indol-3-yl)acetamides with Anticancer Activities
title_short	Reductive Cleavage of 4′ H-Spiro[indole-3,5′-isoxazoles] en Route to 2-(1 H-Indol-3-yl)acetamides with Anticancer Activities
title_full	Reductive Cleavage of 4′ H-Spiro[indole-3,5′-isoxazoles] en Route to 2-(1 H-Indol-3-yl)acetamides with Anticancer Activities
title_fullStr	Reductive Cleavage of 4′ H-Spiro[indole-3,5′-isoxazoles] en Route to 2-(1 H-Indol-3-yl)acetamides with Anticancer Activities
title_full_unstemmed	Reductive Cleavage of 4′ H-Spiro[indole-3,5′-isoxazoles] en Route to 2-(1 H-Indol-3-yl)acetamides with Anticancer Activities
title_sort	reductive cleavage of 4′ h-spiro[indole-3,5′-isoxazoles] en route to 2-(1 h-indol-3-yl)acetamides with anticancer activities
publisher	American Chemical Society
publishDate	2022
url	https://dspace.ncfu.ru/handle/20.500.12258/21960
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Reductive Cleavage of 4′ H-Spiro[indole-3,5′-isoxazoles] en Route to 2-(1 H-Indol-3-yl)acetamides with Anticancer Activities

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