A sequence of acylamination and acylation reactions in polyphosphoric acid – a novel approach to the Friedländer synthesis of 2-arylquinolines

A sequence of acylamination and acylation reactions in polyphosphoric acid – a novel approach to the Friedländer synthesis of 2-arylquinolines

A method for the synthesis of 2-(2-acylaminoaryl)quinolines was developed based on a one-pot sequence of direct electrophilic acylamination of arenes with nitroalkanes in polyphosphoric acid and acylation at the ortho position with respect to the acylamino group.

Shranjeno v:

Bibliografske podrobnosti
Главные авторы:	Grishin, I. Y., Гришин, И. Ю., Malyuga, V. V., Малюга, В. В., Aksenov, D. A., Аксенов, Д. А., Kirilov, N. K., Кирилов, Н. К., Ovcharov, S. N., Овчаров, С. Н., Sarapii, A. V., Сарапий, А. В., Aksenov, N. A., Аксенов, Н. А., Aksenov, A. V., Аксенов, А. В.
Format:	Статья
Jezik:	English
Izdano:	2023
Teme:	Polyphosphoric acid One-pot synthesis Nitro compounds Quinolines Acylamination
Online dostop:	https://dspace.ncfu.ru/handle/20.500.12258/23336
Oznake:	Označite Brez oznak, prvi označite!

Podobne knjige/članki

A novel method for the synthesis of 2-arylquinolin-4(1H)-ones
od: Arutiunov, N. A., и др.
Izdano: (2024)

Synthesis of 3,4-dihydroisoquinolines using nitroalkanes in polyphosphoric acid
od: Aksenov, N. A., и др.
Izdano: (2019)

Synthesis of 2,4-Disubstituted Quinolines by the Reaction of Propargylic Alcohols with Anilines in a Polyphosphoric Acid Medium
od: Aksenov, A. V., и др.
Izdano: (2025)

A facile synthesis of 1-oxo-pyrrolo[2,1-a]isoquinolines
od: Aksenov, A. V., и др.
Izdano: (2018)

A novel multi-component approach to the synthesis of pyrrolo[2,1-a] isoquinoline derivatives
od: Aksenov, A. V., и др.
Izdano: (2018)

Direct C-H functionalization of arenes in reactions with nitroalkanes and nitroalkenes in polyphosphoric acids
od: Aksenov, A. V., и др.
Izdano: (2019)

Synthesis of chromenoimidazocarbolines by a reaction of quaternary iminium salts with o-hydroxybenzaldehydes
od: Aksenov, A. V., и др.
Izdano: (2018)

Preparation of spiro[indole-3,5′-isoxazoles] via Grignard conjugate addition/spirocyclization sequence
od: Aksenov, A. V., и др.
Izdano: (2021)

Does electrophilic activation of nitroalkanes in polyphosphoric acid involve formation of nitrile oxides?
od: Aksenov, A. V., и др.
Izdano: (2021)

One-pot synthesis of 4-methyl-2-alkyl quinazoline-N-oxides by cascade acetamidation–acylation of simple electron-rich arenes with primary nitroalkanes
od: Grishin, I. Y., и др.
Izdano: (2025)

A new series of acetohydroxamates shows in vitro and in vivo anticancer activity against melanoma
od: Aksenov, A. V., и др.
Izdano: (2019)

Mn-mediated sequential three-component domino Knoevenagel/cyclization/Michael addition/oxidative cyclization reaction towards annulated imidazo[1,2-a]pyridines
od: Aksenov, A. V., и др.
Izdano: (2019)

A new synthetic approach to functionalized bicyclo[3.2.1]octanes
od: Dotsenko, V. V., и др.
Izdano: (2018)

A Diastereoselective Assembly of Tetralone Derivatives via a Tandem Michael Reaction and ipso-Substitution of the Nitro Group
od: Aksenov, N. A., и др.
Izdano: (2023)

Dual role of polyphosphoric acid-activated nitroalkanes in oxidative peri -annulations: Efficient synthesis of 1,3,6,8-tetraazapyrenes
od: Aksenov, A. V., и др.
Izdano: (2018)

Nitroalkenes as surrogates for cyanomethylium species in a one-pot synthesis of non-symmetric diarylacetonitriles
od: Aksenov, A. V., и др.
Izdano: (2018)

Introduction of tetrazol-1-yl and 5-methyltetrazol-1-yl substituents in the phenyl ring of dibenzo-18-crown-6
od: Aksenov, N. A., и др.
Izdano: (2018)

Modern trends of organic chemistry in russian universities
od: Aksenov, A. V., и др.
Izdano: (2018)

Electrophilically activated nitroalkanes in double annulation of [1,2,4]triazolo[4,3-a]quinolines and 1,3,4-oxadiazole rings
od: Aksenov, A. V., и др.
Izdano: (2021)

Rational design of an efficient one-pot synthesis of 6H-pyrrolo[2,3,4- gh] perimidines in polyphosphoric acid
od: Aksenov, A. V., и др.
Izdano: (2018)

γ-Hydroxy-γ-butyrolactams as 1,2-bis-electrophiles in a Brønsted/Lewis acid-free synthesis of condensed nitrogen heterocycles
od: Aksenov, N. A., и др.
Izdano: (2024)

Organic Chemistry in Russian Universities. Achievements of Recent Years
od: Aksenov, D. A., и др.
Izdano: (2024)

[3 + 2]-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor
od: Aksenov, A. V., и др.
Izdano: (2021)

Synthesis of spiro[indole-3,5′-isoxazoles] with anticancer activity via a formal [4 + 1]-spirocyclization of nitroalkenes to indoles
od: Aksenov, A. V., и др.
Izdano: (2019)

Syntheses of 3-(2-Nitrovinyl)-indoles, Benzo[a]carbazoles, Naphtho[2,1-a]carbazoles, and 1-Hydroxy-β-carbolines Lead to Identification of Antiproliferative Compounds Active under Hypoxia
od: Arutiunov, N. A., и др.
Izdano: (2024)

Reaction of benzyne with 1,2,3,4-tetrahydroisoquinolines as an access to 1H-3-benzazepines
od: Aksenov, A. V., и др.
Izdano: (2018)

Reactions of 3,4-dihydroisoquinolines and dihydrothieno[3,2-c]pyridines with benzyne
od: Aksenov, A. V., и др.
Izdano: (2018)

Domino reactions of 1-substituted N-(cyanomethyl)isoquinolinium salts with salicylic aldehydes
od: Aksenov, A. V., и др.
Izdano: (2018)

Interaction of condensed tetrahydropyrido[4,3-d]pyrimidin-4-ones with dehydrobenzene – synthesis of 6-vinylpyrimidinones fused with five-membered heterocycle containing two or three heteroatoms
od: Aksenov, A. V., и др.
Izdano: (2018)

5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells
od: Aksenov, A. V., и др.
Izdano: (2018)

Three-component reaction of ketals, isonitriles, and trimethylsilyl azide
od: Aksenov, A. V., и др.
Izdano: (2018)

First synthesis of heterocyclic allenes-benzazecine derivatives
od: Aksenov, A. V., и др.
Izdano: (2018)

Metal-free ring expansion of indoles with nitroalkenes: A simple, modular approach to 3-substituted 2-quinolones
od: Aksenov, A. V., и др.
Izdano: (2019)

Dibenzoylmethane in the Synthesis of Selenium Di- and Tetrahydropyridine-3-carbonitriles
od: Aksenov, N. A., и др.
Izdano: (2025)

New photochromic indoline spiropyrans containing cationic substituent in the 2H-chromene moiety
od: Aksenov, N. A., и др.
Izdano: (2018)

Synthesis of New (2E,4E)-2-Cyano-5-phenylpenta-2,4-dienethioamide Derivatives
od: Aksenov, N. A., и др.
Izdano: (2025)

On the structure of zinc(II) coordination compounds with l-histidine
od: Aksenov, N. A., и др.
Izdano: (2020)

Synthesis of (2E,4E)-2-(4-Aryl-1,3-selenazol-2-yl)-5-phenylpenta-2,4-dienenitriles
od: Aksenov, N. A., и др.
Izdano: (2025)

Structure and properties of europium (III) triaquatriglycinate chloride
od: Aksenov, N. A., и др.
Izdano: (2020)

A Two-Step Synthesis of Unprotected 3-Aminoindoles via Post Functionalization with Nitrostyrene
od: Aksenov, N. A., и др.
Izdano: (2023)