इसे छोड़कर सामग्री पर बढ़ने के लिए

A genome-wide search of meat productivity candidate genes in Russian Meat Merino breed

A genome-wide associations study (GWAS) of single nucleotide polymorphisms (SNP) with indicators of meat productivity in Russian Meat Merino was carried out. A new approach is based on the selection of animals for research considered with known productivity genes (MSTN, MYOD1, etc.). Animal genotypi...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Krivoruchko, A. Y., Криворучко, А. Ю., Likhovid, N. G., Лиховид, Н. Г., Likhovid, A. A., Лиховид, А. А.
स्वरूप: Статья
भाषा:English
प्रकाशित: 2023
विषय:
ऑनलाइन पहुंच:https://dspace.ncfu.ru/handle/20.500.12258/23491
टैग : टैग जोड़ें
कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!
id ir-20.500.12258-23491
record_format dspace
spelling ir-20.500.12258-234912023-05-24T11:20:24Z A genome-wide search of meat productivity candidate genes in Russian Meat Merino breed Krivoruchko, A. Y. Криворучко, А. Ю. Likhovid, N. G. Лиховид, Н. Г. Likhovid, A. A. Лиховид, А. А. Russian meat merino breed Meat productivity Candidate genes A genome-wide associations study (GWAS) of single nucleotide polymorphisms (SNP) with indicators of meat productivity in Russian Meat Merino was carried out. A new approach is based on the selection of animals for research considered with known productivity genes (MSTN, MYOD1, etc.). Animal genotyping was performed using Ovine Infinium HD BeadChip 600 K (Illumina, USA). As a result, 20 SNPs significantly associated with the body measurements and ultrasound parameters of the animals were identified. Around these SNPs, 14 candidate genes were discovered. Investigated parameters of phenotype can be associated with structural disorders in these genes. Most SNPs were located in the intergenic space, two polymorphisms were located in the Upstream and Downstream regions. One SNP was localized in the intron, two are in the exon of genes. Two substitutions were next to the long non-coding RNA and micro-RNA. The following candidate genes were annotated: ASB3, THADA, PRPS1L1, Ccdc130, MTHFS, RALGAPA1, MEIS1, AKIRIN1, GRXCR1, Lrig1, ANKS1B, CFI, KRAB, and SLCO2B1. These genes are involved in some metabolic processes of cell proliferation and differentiation, function of neurons and immune system. Further research should be oriented to study the structure of these genes and use discovered SNPs as new molecular markers in breeding. 2023-05-24T11:19:20Z 2023-05-24T11:19:20Z 2023 Статья Krivoruchko, A., Surov, A., Kanibolotskaya, A., Sheludko, P., Likhovid, N., Yatsyk, O., Likhovid, A. A genome-wide search of meat productivity candidate genes in Russian Meat Merino breed // Animal Gene. - 2023. - 27, 200146. - DOI: 10.1016/j.angen.2023.200146 http://hdl.handle.net/20.500.12258/23491 en Animal Gene application/pdf
institution СКФУ
collection Репозиторий
language English
topic Russian meat merino breed
Meat productivity
Candidate genes
spellingShingle Russian meat merino breed
Meat productivity
Candidate genes
Krivoruchko, A. Y.
Криворучко, А. Ю.
Likhovid, N. G.
Лиховид, Н. Г.
Likhovid, A. A.
Лиховид, А. А.
A genome-wide search of meat productivity candidate genes in Russian Meat Merino breed
description A genome-wide associations study (GWAS) of single nucleotide polymorphisms (SNP) with indicators of meat productivity in Russian Meat Merino was carried out. A new approach is based on the selection of animals for research considered with known productivity genes (MSTN, MYOD1, etc.). Animal genotyping was performed using Ovine Infinium HD BeadChip 600 K (Illumina, USA). As a result, 20 SNPs significantly associated with the body measurements and ultrasound parameters of the animals were identified. Around these SNPs, 14 candidate genes were discovered. Investigated parameters of phenotype can be associated with structural disorders in these genes. Most SNPs were located in the intergenic space, two polymorphisms were located in the Upstream and Downstream regions. One SNP was localized in the intron, two are in the exon of genes. Two substitutions were next to the long non-coding RNA and micro-RNA. The following candidate genes were annotated: ASB3, THADA, PRPS1L1, Ccdc130, MTHFS, RALGAPA1, MEIS1, AKIRIN1, GRXCR1, Lrig1, ANKS1B, CFI, KRAB, and SLCO2B1. These genes are involved in some metabolic processes of cell proliferation and differentiation, function of neurons and immune system. Further research should be oriented to study the structure of these genes and use discovered SNPs as new molecular markers in breeding.
format Статья
author Krivoruchko, A. Y.
Криворучко, А. Ю.
Likhovid, N. G.
Лиховид, Н. Г.
Likhovid, A. A.
Лиховид, А. А.
author_facet Krivoruchko, A. Y.
Криворучко, А. Ю.
Likhovid, N. G.
Лиховид, Н. Г.
Likhovid, A. A.
Лиховид, А. А.
author_sort Krivoruchko, A. Y.
title A genome-wide search of meat productivity candidate genes in Russian Meat Merino breed
title_short A genome-wide search of meat productivity candidate genes in Russian Meat Merino breed
title_full A genome-wide search of meat productivity candidate genes in Russian Meat Merino breed
title_fullStr A genome-wide search of meat productivity candidate genes in Russian Meat Merino breed
title_full_unstemmed A genome-wide search of meat productivity candidate genes in Russian Meat Merino breed
title_sort genome-wide search of meat productivity candidate genes in russian meat merino breed
publishDate 2023
url https://dspace.ncfu.ru/handle/20.500.12258/23491
work_keys_str_mv AT krivoruchkoay agenomewidesearchofmeatproductivitycandidategenesinrussianmeatmerinobreed
AT krivoručkoaû agenomewidesearchofmeatproductivitycandidategenesinrussianmeatmerinobreed
AT likhovidng agenomewidesearchofmeatproductivitycandidategenesinrussianmeatmerinobreed
AT lihovidng agenomewidesearchofmeatproductivitycandidategenesinrussianmeatmerinobreed
AT likhovidaa agenomewidesearchofmeatproductivitycandidategenesinrussianmeatmerinobreed
AT lihovidaa agenomewidesearchofmeatproductivitycandidategenesinrussianmeatmerinobreed
AT krivoruchkoay genomewidesearchofmeatproductivitycandidategenesinrussianmeatmerinobreed
AT krivoručkoaû genomewidesearchofmeatproductivitycandidategenesinrussianmeatmerinobreed
AT likhovidng genomewidesearchofmeatproductivitycandidategenesinrussianmeatmerinobreed
AT lihovidng genomewidesearchofmeatproductivitycandidategenesinrussianmeatmerinobreed
AT likhovidaa genomewidesearchofmeatproductivitycandidategenesinrussianmeatmerinobreed
AT lihovidaa genomewidesearchofmeatproductivitycandidategenesinrussianmeatmerinobreed
_version_ 1809808923040940032