An Effective Synthesis of Previously Unknown 7-Aryl Substituted Paullones

An Effective Synthesis of Previously Unknown 7-Aryl Substituted Paullones

A straightforward three-step procedure affording a wide range of novel 7-aryl substituted paullone derivatives was developed. This scaffold is structurally similar to 2-(1H-indol-3-yl)acetamides-promising antitumor agents-hence, could be useful for the development of a new class of anticancer drugs.

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Bibliografiske detaljer
Главные авторы:	Aksenov, D. A., Аксенов, Д. А., Akulova, A. S., Акулова, А. С., Aleksandrova, E. A., Александрова, Е. А., Aksenov, N. A., Аксенов, Н. А., Leontiev, A. V., Леонтьев, А. В., Aksenov, A. V., Аксенов, А. В.
Format:	Статья
Sprog:	English
Udgivet:	2023
Fag:	Anticancer drug discovery Paullones synthesis Fisher indolization
Online adgang:	https://dspace.ncfu.ru/handle/20.500.12258/23587
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Lignende værker

Synthesis of spiro[indole-3,5′-isoxazoles] with anticancer activity via a formal [4 + 1]-spirocyclization of nitroalkenes to indoles
af: Aksenov, A. V., и др.
Udgivet: (2019)

2-(3-Indolyl)acetamides and their oxazoline analogues: Anticancer SAR study
af: Aksenov, D. A., и др.
Udgivet: (2024)

Direct reductive coupling of indoles to nitrostyrenes en route to (indol-3-yl)acetamides
af: Aksenov, A. V., и др.
Udgivet: (2018)

Synthesis of 2-(1H-Indol-2-yl)acetamides via bronsted acid-assisted cyclization cascade
af: Aksenov, N. A., и др.
Udgivet: (2020)

Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells
af: Aksenov, A. V., и др.
Udgivet: (2018)

Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic acids and evaluation of cytotoxic activity of the products
af: Aksenov, D. A., и др.
Udgivet: (2022)

Nitrostyrenes as 1,4-CCNO-dipoles: diastereoselective formal [4+1] cycloaddition of indoles
af: Aksenov, A. V., и др.
Udgivet: (2018)

A new series of acetohydroxamates shows in vitro and in vivo anticancer activity against melanoma
af: Aksenov, A. V., и др.
Udgivet: (2019)

Convenient synthesis of (Z)-3-(1-aryl-2-nitrovinyl)-indoles
af: Arutiunov, N. A., и др.
Udgivet: (2023)

Novel convenient one-pot method for the synthesis of indoloquinolines
af: Aksenov, N. A., и др.
Udgivet: (2019)

One-Pot Synthesis of Polynuclear Indole Derivatives by Friedel-Crafts Alkylation of γ-Hydroxybutyrolactams
af: Abaev, V. T., и др.
Udgivet: (2023)

Michael addition to 3-(2-nitrovinyl)indoles – route toward aliphatic nitro compounds with heterocyclic substituents
af: Aksenov, N. A., и др.
Udgivet: (2019)

Novel Two-Step Synthesis of N -Alkylated 2,3-Diaryl-4-quinolones
af: Aksenov, A. V., и др.
Udgivet: (2024)

Histological studies of organs in experiment on the application of a niosomal form of anti-tumor medicine
af: Aksenov, A. V., и др.
Udgivet: (2020)

Michael addition to unprotected 3-(2-nitrovinyl)indoles under the conditions of microwave synthesis
af: Aksenov, A. V., и др.
Udgivet: (2018)

Synthesis of meta-substituted anilines via a three-component reaction of acetone, amines, and 1,3-diketones
af: Rubin, M. A., и др.
Udgivet: (2019)

A nitroalkane-based approach to one-pot three-component synthesis of isocryptolepine and its analogs with potent anti-cancer activities
af: Aksenov, N. A., и др.
Udgivet: (2018)

An efficient synthesis of (3-indolyl)acetonitriles by reduction of hydroxamic acids
af: Aksenov, A. V., и др.
Udgivet: (2018)

[3 + 2]-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor
af: Aksenov, A. V., и др.
Udgivet: (2021)

Methods of synthesis of natural indoloquinolines isolated from Cryptolepis sanguinolenta
af: Nadein, O. N., и др.
Udgivet: (2019)

Synthesis of β-Carbolines with Electrocyclic Cyclization of 3-Nitrovinylindoles
af: Aksenov, N. A., и др.
Udgivet: (2023)

Improved method for preparation of 3-(1H-Indol-3-yl)benzofuran-2(3H)-ones
af: Grishin, I. Y., и др.
Udgivet: (2022)

Domino reactions of 1-substituted N-(cyanomethyl)isoquinolinium salts with salicylic aldehydes
af: Aksenov, A. V., и др.
Udgivet: (2018)

A Two-Step Synthesis of Unprotected 3-Aminoindoles via Post Functionalization with Nitrostyrene
af: Aksenov, N. A., и др.
Udgivet: (2023)

Microwave synthesis of 2-[(E)-2-(1H-indol-3-yl)vinyl]hetarenes
af: Aksenov, A. V., и др.
Udgivet: (2018)

One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-Ylidene)-2-Arylacetonitriles
af: Aksenov, N. A., и др.
Udgivet: (2022)

Novel reactions of 1-cyanoacetyl-3,5-dimethylpyrazole (microreview)
af: Dotsenko, V. V., и др.
Udgivet: (2020)

Chemistry and biology of ophiobolin A and its congeners
af: Kornienko, A. V., и др.
Udgivet: (2019)

A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams
af: Aksenov, A. V., и др.
Udgivet: (2023)

Synthesis of 2-carboxyaniline-substituted maleimides from 2'-nitrochalcones
af: Aksenov, N. A., и др.
Udgivet: (2023)

Accelerating extreme search based on natural gradient descent with beta distribution
af: Lyakhov, P. A., и др.
Udgivet: (2022)

One-step synthesis of 4-methyl-2-substituted quinazoline-3-oxides via polyphosphoric acid catalyzed acylation of electron-rich anilides with nitroethane
af: Grishin, I. Y., и др.
Udgivet: (2024)

5% suspension of albendazole echinacea magenta (Echinacea Purpurea) toxicometric evaluation
af: Pushkin, S. V., и др.
Udgivet: (2019)

A Diastereoselective Assembly of Tetralone Derivatives via a Tandem Michael Reaction and ipso-Substitution of the Nitro Group
af: Aksenov, N. A., и др.
Udgivet: (2023)

Synthetic studies toward 1,2,3,3a,4,8b-Hexahydropyrrolo[3,2-b]indole core. Unusual fragmentation with 1,2-Aryl Shift
af: Aksenov, A. V., и др.
Udgivet: (2022)

Electrophilically activated nitroalkanes in the synthesis of substituted 1,3,4-oxadiazoles from amino acid derivatives
af: Aksenov, A. V., и др.
Udgivet: (2022)

Improving extreme search with natural gradient descent using dirichlet distribution
af: Abdulkadirov, R. I., и др.
Udgivet: (2022)

Solving Poisson Equation by Physics-Informed Neural Network with Natural Gradient Descent with Momentum
af: Abdulkadirov, R. I., и др.
Udgivet: (2024)

Modern trends of organic chemistry in russian universities
af: Aksenov, A. V., и др.
Udgivet: (2018)

Introduction of tetrazol-1-yl and 5-methyltetrazol-1-yl substituents in the phenyl ring of dibenzo-18-crown-6
af: Aksenov, N. A., и др.
Udgivet: (2018)