New 6'-Amino-5'-cyano-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-pyridine]-3'-carboxamides: Synthesis, Reactions, Molecular Docking Studies and Biological Activity

New 6'-Amino-5'-cyano-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-pyridine]-3'-carboxamides: Synthesis, Reactions, Molecular Docking Studies and Biological Activity

The purpose of this work was to prepare new isatin- and monothiomalondiamide-based indole derivatives, as well as to study the properties of the new compounds. The four-component reaction of 5-R-isatins (R = H, CH3), malononitrile, monothiomalonamide (3-amino-3-thioxo- propanamide) and triethylamine...

Полное описание

Сохранить в:

Библиографические подробности
Главные авторы:	Dotsenko, V. V., Доценко, В. В., Aksenov, N. A., Аксенов, Н. А., Aksenova, I. V., Аксенова, И. В.
Формат:	Статья
Язык:	English
Опубликовано:	2023
Темы:	Michael addition Docking studies Herbicide safeners Spiro-[indoline-3,4′-pyridines] Malononitrile Monothiomalonamide Isatins
Online-ссылка:	https://dspace.ncfu.ru/handle/20.500.12258/23780
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!

Схожие документы

Alkyl 4-Aryl-6-amino-7- phenyl-3-(phenylimino)-4,7-dihydro- 3H-[1,2]dithiolo[3,4-b]pyridine-5-carboxylates: Synthesis and Agrochemical Studies
Автор: Dotsenko, V. V., и др.
Опубликовано: (2023)

Reaction of 3-Amino-4,6-diarylthieno[2,3-b]pyridine-2-carboxamides with Ninhydrin
Автор: Dotsenko, V. V., и др.
Опубликовано: (2020)

1,3-Dithiocyanatoacetone: improved synthesis, detailed structural studies and in silico docking studies
Автор: Dotsenko, V. V., и др.
Опубликовано: (2024)

Synthesis of 2,2-Dimethyl-2,3-dihydropyrido[3′,2′:4,5]-thieno[3,2-d]pyrimidin-4(1H)-ones by Reaction of 3-Aminothieno[2,3-b]pyridine-2-carboxamides with Acetone
Автор: Dotsenko, V. V., и др.
Опубликовано: (2025)

Unusual oxidative dimerization in the 3-aminothieno[2,3- b]pyridine-2-carboxamide series
Автор: Dotsenko, V. V., и др.
Опубликовано: (2021)

A novel method for the synthesis of 2-arylquinolin-4(1H)-ones
Автор: Arutiunov, N. A., и др.
Опубликовано: (2024)

One-Pot Synthesis of N-Fused Quinolone-4 Tetracyclic Scaffolds from 2,2-Disubstituted Indolin-3-ones
Автор: Arutiunov, N. A., и др.
Опубликовано: (2024)

New photochromic indoline spiropyrans containing cationic substituent in the 2H-chromene moiety
Автор: Aksenov, N. A., и др.
Опубликовано: (2018)

Recent advances in chemistry of β-cyano ketones
Автор: Aksenov, N. A., и др.
Опубликовано: (2025)

Synthesis and structure of new 2,4-dicyano-6-oxo-3-phenylbicyclo[3.2.1]octane-2,4-dicarboxylates
Автор: Dotsenko, V. V., и др.
Опубликовано: (2020)

7-Aryl-3-(hydroxymethyl)-5-oxo-1,2,3,5-tetrahydro[1,2,4]triazolo[1,5-a]pyridine-6,8-dicarbonitriles: Synthesis and Predicted Biological Activity
Автор: Dotsenko, V. V., и др.
Опубликовано: (2022)

Preparation of spiro[indole-3,5′-isoxazoles] via Grignard conjugate addition/spirocyclization sequence
Автор: Aksenov, A. V., и др.
Опубликовано: (2021)

Aminomethylation of Guareschi imides: synthesis of 2,4-dioxo-1H,5H-3,7-spiro[diazabicyclo[3.3.1]nonane-9,4'-piperidine]-1,5-dicarbonitriles
Автор: Dotsenko, V. V., и др.
Опубликовано: (2018)

Synthesis and Structure of 4-[(anthracene-9′-ylmethylene)amino]-5-R-2,4-Dihydro-3H-1,2,4-Triazole-3-Thiones
Автор: Demidov, O. P., и др.
Опубликовано: (2024)

Synthesis, structure, and analgesic activity of 4-(5-Cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic acids ethyl esters
Автор: Dotsenko, V. V., и др.
Опубликовано: (2022)

A facile synthesis of 1-oxo-pyrrolo[2,1-a]isoquinolines
Автор: Aksenov, A. V., и др.
Опубликовано: (2018)

Reactions of 3,4-dihydroisoquinolines and dihydrothieno[3,2-c]pyridines with benzyne
Автор: Aksenov, A. V., и др.
Опубликовано: (2018)

Synthesis of spiro[indole-3,5′-isoxazoles] with anticancer activity via a formal [4 + 1]-spirocyclization of nitroalkenes to indoles
Автор: Aksenov, A. V., и др.
Опубликовано: (2019)

Synthesis and properties of 4,6-Dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile and 3-Amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines
Автор: Dotsenko, V. V., и др.
Опубликовано: (2019)

Oxidative Cyclization of 4-(2-Aminophenyl)-4-oxo-2-phenylbutanenitriles into 2-(3-Oxoindolin-2-ylidene)acetonitriles
Автор: Aksenov, N. A., и др.
Опубликовано: (2022)

Reaction of thieno[2,3-b]pyridines with sodium hypochlorite: An unusual and stereoselective one-pot approach to dimeric pyrrolo[2′,3′:4,5]thieno[2,3-b]pyridines
Автор: Dotsenko, V. V., и др.
Опубликовано: (2019)

Preparation of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2: H -pyrrol-2-ones via base-assisted cyclization of 3-cyanoketones
Автор: Aksenov, N. A., и др.
Опубликовано: (2021)

Substituted N-(thieno[2,3-b]pyridine-3-yl)acetamides: synthesis, reactions, and biological activity
Автор: Dotsenko, V. V., и др.
Опубликовано: (2019)

Electrophilically activated nitroalkanes in the synthesis of 6,7-dihydro-1H-cyclopenta[g]perimidines
Автор: Aksenov, A. V., и др.
Опубликовано: (2018)

Methylene Components Exchange in the Reaction of Cyanoacetohydrazide with 2-Amino-4-arylbuta-1,3-diene-1,1,3-tricarbonitriles
Автор: Dotsenko, V. V., и др.
Опубликовано: (2021)

A facile approach to the synthesis of 3,4-dihydro-2H-benzo[4,5]imidazo[2,1-b][1,3,4]thiadiazines
Автор: Pobedinskaya, D. Y., и др.
Опубликовано: (2024)

Synthesis and properties of new fluorine-containing thieno[2,3-b]pyridine derivatives
Автор: Dotsenko, V. V., и др.
Опубликовано: (2019)

New Heterocyclisation Reactions of 5-Amino-3-(cyanomethyl)-1H-pyrazole-4-carbonitrile with Some 1,3-Dielectrophilic Agents
Автор: Dotsenko, V. V., и др.
Опубликовано: (2022)

Reaction of 5-Amino-3-(cyanomethyl)-1H-pyrazole-4-carbonitrile with Hydroxycyclohexanones
Автор: Dotsenko, V. V., и др.
Опубликовано: (2019)

Fundamentals of molecular magnetism textbook
Автор: Lukov, V. V.

Synthesis of New (2E,4E)-2-Cyano-5-phenylpenta-2,4-dienethioamide Derivatives
Автор: Aksenov, N. A., и др.
Опубликовано: (2025)

Synthesis and luminescent properties of Eu3+ and Tb3+ Complexes with Coumarin-3-carboxylic Acids
Автор: Dotsenko, V. V., и др.
Опубликовано: (2021)

Some new reactions and properties of xanthane hydride (5-amino-1,2,4-dithiazole-3-thione)
Автор: Dotsenko, V. V., и др.
Опубликовано: (2018)

Oxidative Dimerization of (Thiazol-2-yl)acetonitriles with Molecular Iodine: Synthesis and Structure of 2,3-Bis(4-aryl-1,3-thiazol-2-yl)but-2-enedinitriles
Автор: Dotsenko, V. V., и др.
Опубликовано: (2024)

Synthesis of new functionalized 3,7-diazabicyclo[3.3.1]nonanes by aminomethylation of the Guareschi imides
Автор: Dotsenko, V. V., и др.
Опубликовано: (2018)

2-Amino-4,5-dihydrothiophene-3-carbonitriles: A New Synthesis, Quantum Chemical Studies, and Mannich-Type Reactions Leading to New Hexahydrothieno[2,3-d]pyrimidines
Автор: Dotsenko, V. V., и др.
Опубликовано: (2021)

6-(Pyrazol-1-yl)pyrazolo[3,4-b]pyridines: Synthesis, Structure, and Wheat Growth Regulating Activity
Автор: Dotsenko, V. V., и др.
Опубликовано: (2024)

Synthesis and luminescent properties of Eu3+, Gd3+, and Tb3+ complexes with quinoline-4-carboxylic acids
Автор: Aksenova, I. V., и др.
Опубликовано: (2020)

Synthesis and Aminomethylation of 6-Amino-2-(dicyanomethylene)-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitrile Morpholinium Salt
Автор: Dotsenko, V. V., и др.
Опубликовано: (2021)

First Synthesis of 2-Amino-5-hydroxy-4H-chromene-3-carbonitriles from 4-(2-Pyridylazo)resorcinol
Автор: Dotsenko, V. V., и др.
Опубликовано: (2023)