A Diastereoselective Assembly of Tetralone Derivatives via a Tandem Michael Reaction and ipso-Substitution of the Nitro Group

A highly diastereoselective tandem reaction of 2'-nitrochalcones is reported, involving Michael addition and a subsequent ipso-substitution of the nitro group to produce 1-tetralones with two contiguous chiral centers. A related annulation reaction of 2'-nitrochalcones with potassium cyani...

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Главные авторы:	Aksenov, N. A., Аксенов, Н. А., Aksenov, D. A., Аксенов, Д. А., Ganusenko, D. D., Ганусенко, Д. Д., Kurenkov, I. A., Куренков, И. А., Aksenov, A. V., Аксенов, А. В.
Формат:	Статья
Язык:	English
Опубликовано:	2023
Темы:	Tandem Michael reaction Ipso-substitution of the nitro group Tetralone derivatives
Online-ссылка:	https://dspace.ncfu.ru/handle/20.500.12258/23806
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id	ir-20.500.12258-23806
record_format	dspace
spelling	ir-20.500.12258-238062025-02-11T08:34:28Z A Diastereoselective Assembly of Tetralone Derivatives via a Tandem Michael Reaction and ipso-Substitution of the Nitro Group Aksenov, N. A. Аксенов, Н. А. Aksenov, D. A. Аксенов, Д. А. Ganusenko, D. D. Ганусенко, Д. Д. Kurenkov, I. A. Куренков, И. А. Aksenov, A. V. Аксенов, А. В. Tandem Michael reaction Ipso-substitution of the nitro group Tetralone derivatives A highly diastereoselective tandem reaction of 2'-nitrochalcones is reported, involving Michael addition and a subsequent ipso-substitution of the nitro group to produce 1-tetralones with two contiguous chiral centers. A related annulation reaction of 2'-nitrochalcones with potassium cyanide affording 1-indanones with a C3-quaternary chiral center is also demonstrated. 2023-06-30T12:23:59Z 2023-06-30T12:23:59Z 2023 Статья Aksenov, N.A., Aksenov, D.A., Ganusenko, D.D., Kurenkov, I.A., Aksenov, A.V. A Diastereoselective Assembly of Tetralone Derivatives via a Tandem Michael Reaction and ipso-Substitution of the Nitro Group // Journal of Organic Chemistry. - 2023. - 88(9), pp, 5639–5651. - DOI: 10.1021/acs.joc.3c00134 http://hdl.handle.net/20.500.12258/23806 en Journal of Organic Chemistry application/pdf application/pdf
institution	СКФУ
collection	Репозиторий
language	English
topic	Tandem Michael reaction Ipso-substitution of the nitro group Tetralone derivatives
spellingShingle	Tandem Michael reaction Ipso-substitution of the nitro group Tetralone derivatives Aksenov, N. A. Аксенов, Н. А. Aksenov, D. A. Аксенов, Д. А. Ganusenko, D. D. Ганусенко, Д. Д. Kurenkov, I. A. Куренков, И. А. Aksenov, A. V. Аксенов, А. В. A Diastereoselective Assembly of Tetralone Derivatives via a Tandem Michael Reaction and ipso-Substitution of the Nitro Group
description	A highly diastereoselective tandem reaction of 2'-nitrochalcones is reported, involving Michael addition and a subsequent ipso-substitution of the nitro group to produce 1-tetralones with two contiguous chiral centers. A related annulation reaction of 2'-nitrochalcones with potassium cyanide affording 1-indanones with a C3-quaternary chiral center is also demonstrated.
format	Статья
author	Aksenov, N. A. Аксенов, Н. А. Aksenov, D. A. Аксенов, Д. А. Ganusenko, D. D. Ганусенко, Д. Д. Kurenkov, I. A. Куренков, И. А. Aksenov, A. V. Аксенов, А. В.
author_facet	Aksenov, N. A. Аксенов, Н. А. Aksenov, D. A. Аксенов, Д. А. Ganusenko, D. D. Ганусенко, Д. Д. Kurenkov, I. A. Куренков, И. А. Aksenov, A. V. Аксенов, А. В.
author_sort	Aksenov, N. A.
title	A Diastereoselective Assembly of Tetralone Derivatives via a Tandem Michael Reaction and ipso-Substitution of the Nitro Group
title_short	A Diastereoselective Assembly of Tetralone Derivatives via a Tandem Michael Reaction and ipso-Substitution of the Nitro Group
title_full	A Diastereoselective Assembly of Tetralone Derivatives via a Tandem Michael Reaction and ipso-Substitution of the Nitro Group
title_fullStr	A Diastereoselective Assembly of Tetralone Derivatives via a Tandem Michael Reaction and ipso-Substitution of the Nitro Group
title_full_unstemmed	A Diastereoselective Assembly of Tetralone Derivatives via a Tandem Michael Reaction and ipso-Substitution of the Nitro Group
title_sort	diastereoselective assembly of tetralone derivatives via a tandem michael reaction and ipso-substitution of the nitro group
publishDate	2023
url	https://dspace.ncfu.ru/handle/20.500.12258/23806
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A Diastereoselective Assembly of Tetralone Derivatives via a Tandem Michael Reaction and ipso-Substitution of the Nitro Group

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