A Two-Step Synthesis of Unprotected 3-Aminoindoles via Post Functionalization with Nitrostyrene

A novel, low-cost method for the preparation of not easily accessible free 3-aminoindoles has been developed. This approach is based on a well-established reaction between indoles and nitrostyrene in the presence of phosphorous acid, which results in the formation of 4′-phenyl-4′H-spiro[indole-3,5′-...

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Главные авторы:	Aksenov, N. A., Аксенов, Н. А., Arutiunov, N. A., Арутюнов, Н. А., Kurenkov, I. A., Куренков, И. А., Malyuga, V. V., Малюга, В. В., Aksenov, D. A., Аксенов, Д. А., Momotova, D. S., Момотова, Д. С., Zatsepilina, A. M., Зацепилина, А. М., Chukanova, E. A., Чуканова, Е. А., Leontiev, A. V., Леонтьев, А. В., Aksenov, A. V., Аксенов, А. В.
Формат:	Статья
Язык:	English
Опубликовано:	2023
Темы:	Cascade transformations Phenylacetonitrile extrusion C3-amination of indoles
Online-ссылка:	https://dspace.ncfu.ru/handle/20.500.12258/24002
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id	ir-20.500.12258-24002
record_format	dspace
spelling	ir-20.500.12258-240022025-02-11T11:45:37Z A Two-Step Synthesis of Unprotected 3-Aminoindoles via Post Functionalization with Nitrostyrene Aksenov, N. A. Аксенов, Н. А. Arutiunov, N. A. Арутюнов, Н. А. Kurenkov, I. A. Куренков, И. А. Malyuga, V. V. Малюга, В. В. Aksenov, D. A. Аксенов, Д. А. Momotova, D. S. Момотова, Д. С. Zatsepilina, A. M. Зацепилина, А. М. Chukanova, E. A. Чуканова, Е. А. Leontiev, A. V. Леонтьев, А. В. Aksenov, A. V. Аксенов, А. В. Cascade transformations Phenylacetonitrile extrusion C3-amination of indoles A novel, low-cost method for the preparation of not easily accessible free 3-aminoindoles has been developed. This approach is based on a well-established reaction between indoles and nitrostyrene in the presence of phosphorous acid, which results in the formation of 4′-phenyl-4′H-spiro[indole-3,5′-isoxazoles]. The latter could be transformed to corresponding aminated indoles by reaction with hydrazine hydrate in good or excellent yields upon microwave-assisted heating. 2023-07-05T14:28:23Z 2023-07-05T14:28:23Z 2023 Статья Aksenov, N.A., Arutiunov, N.A., Kurenkov, I.A., Malyuga, V.V., Aksenov, D.A., Momotova, D.S., Zatsepilina, A.M., Chukanova, E.A., Leontiev, A.V., Aksenov, A.V. A Two-Step Synthesis of Unprotected 3-Aminoindoles via Post Functionalization with Nitrostyrene // Molecules. - 2023. - 28(9), art. no. 3657. - DOI: 10.3390/molecules28093657 http://hdl.handle.net/20.500.12258/24002 en Molecules application/pdf application/pdf
institution	СКФУ
collection	Репозиторий
language	English
topic	Cascade transformations Phenylacetonitrile extrusion C3-amination of indoles
spellingShingle	Cascade transformations Phenylacetonitrile extrusion C3-amination of indoles Aksenov, N. A. Аксенов, Н. А. Arutiunov, N. A. Арутюнов, Н. А. Kurenkov, I. A. Куренков, И. А. Malyuga, V. V. Малюга, В. В. Aksenov, D. A. Аксенов, Д. А. Momotova, D. S. Момотова, Д. С. Zatsepilina, A. M. Зацепилина, А. М. Chukanova, E. A. Чуканова, Е. А. Leontiev, A. V. Леонтьев, А. В. Aksenov, A. V. Аксенов, А. В. A Two-Step Synthesis of Unprotected 3-Aminoindoles via Post Functionalization with Nitrostyrene
description	A novel, low-cost method for the preparation of not easily accessible free 3-aminoindoles has been developed. This approach is based on a well-established reaction between indoles and nitrostyrene in the presence of phosphorous acid, which results in the formation of 4′-phenyl-4′H-spiro[indole-3,5′-isoxazoles]. The latter could be transformed to corresponding aminated indoles by reaction with hydrazine hydrate in good or excellent yields upon microwave-assisted heating.
format	Статья
author	Aksenov, N. A. Аксенов, Н. А. Arutiunov, N. A. Арутюнов, Н. А. Kurenkov, I. A. Куренков, И. А. Malyuga, V. V. Малюга, В. В. Aksenov, D. A. Аксенов, Д. А. Momotova, D. S. Момотова, Д. С. Zatsepilina, A. M. Зацепилина, А. М. Chukanova, E. A. Чуканова, Е. А. Leontiev, A. V. Леонтьев, А. В. Aksenov, A. V. Аксенов, А. В.
author_facet	Aksenov, N. A. Аксенов, Н. А. Arutiunov, N. A. Арутюнов, Н. А. Kurenkov, I. A. Куренков, И. А. Malyuga, V. V. Малюга, В. В. Aksenov, D. A. Аксенов, Д. А. Momotova, D. S. Момотова, Д. С. Zatsepilina, A. M. Зацепилина, А. М. Chukanova, E. A. Чуканова, Е. А. Leontiev, A. V. Леонтьев, А. В. Aksenov, A. V. Аксенов, А. В.
author_sort	Aksenov, N. A.
title	A Two-Step Synthesis of Unprotected 3-Aminoindoles via Post Functionalization with Nitrostyrene
title_short	A Two-Step Synthesis of Unprotected 3-Aminoindoles via Post Functionalization with Nitrostyrene
title_full	A Two-Step Synthesis of Unprotected 3-Aminoindoles via Post Functionalization with Nitrostyrene
title_fullStr	A Two-Step Synthesis of Unprotected 3-Aminoindoles via Post Functionalization with Nitrostyrene
title_full_unstemmed	A Two-Step Synthesis of Unprotected 3-Aminoindoles via Post Functionalization with Nitrostyrene
title_sort	two-step synthesis of unprotected 3-aminoindoles via post functionalization with nitrostyrene
publishDate	2023
url	https://dspace.ncfu.ru/handle/20.500.12258/24002
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A Two-Step Synthesis of Unprotected 3-Aminoindoles via Post Functionalization with Nitrostyrene

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