Unexpected cyclization of 2-(2-aminophenyl)indoles with nitroalkenes to furnish indolo[3,2-: C] quinolines

The polyphosphoric acid-mediated reaction of 2-(2-aminophenyl)indenes with nitroalkenes was tested in the frame of synthetic studies towards CDK inhibitors with the paullone core. Unexpectedly, this reaction proceeded via a different mechanistic pathway affording derivatives of the natural alkaloid...

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Главные авторы:	Aksenov, A. V., Аксенов, А. В., Aksenov, D. A., Аксенов, Д. А., Griaznov, G. D., Грязнов, Г. Д., Aksenov, N. A., Аксенов, Н. А., Rubin, M. A., Рубин, М. А.
Формат:	Статья
Язык:	English
Опубликовано:	Royal Society of Chemistry 2018
Темы:	Positive ions CDK inhibitors Mechanistic pathways Mediated reactions Nitroalkenes Polyphosphoric acids Synthetic study Chemistry
Online-ссылка:	https://dspace.ncfu.ru:443/handle/20.500.12258/2446
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spelling	ir-20.500.12258-24462025-02-13T09:29:18Z Unexpected cyclization of 2-(2-aminophenyl)indoles with nitroalkenes to furnish indolo[3,2-: C] quinolines Aksenov, A. V. Аксенов, А. В. Aksenov, D. A. Аксенов, Д. А. Griaznov, G. D. Грязнов, Г. Д. Aksenov, N. A. Аксенов, Н. А. Rubin, M. A. Рубин, М. А. Positive ions CDK inhibitors Mechanistic pathways Mediated reactions Nitroalkenes Polyphosphoric acids Synthetic study Chemistry The polyphosphoric acid-mediated reaction of 2-(2-aminophenyl)indenes with nitroalkenes was tested in the frame of synthetic studies towards CDK inhibitors with the paullone core. Unexpectedly, this reaction proceeded via a different mechanistic pathway affording derivatives of the natural alkaloid isocryptolepine. The scope of this unusual transformation was investigated and a mechanistic rationale explaining this outcome is offered 2018-07-25T14:32:00Z 2018-07-25T14:32:00Z 2018 Статья Aksenov, A.V., Aksenov, D.A., Griaznov, G.D., Aksenov, N.A., Voskressensky, L.G., Rubin, M. Unexpected cyclization of 2-(2-aminophenyl)indoles with nitroalkenes to furnish indolo[3,2-: C] quinolines // Organic and Biomolecular Chemistry. - 2018. - Volume 16. - Issue 23. - Pages 4325-4332 https://dspace.ncfu.ru:443/handle/20.500.12258/2446 en Organic and Biomolecular Chemistry application/pdf application/pdf Royal Society of Chemistry
institution	СКФУ
collection	Репозиторий
language	English
topic	Positive ions CDK inhibitors Mechanistic pathways Mediated reactions Nitroalkenes Polyphosphoric acids Synthetic study Chemistry
spellingShingle	Positive ions CDK inhibitors Mechanistic pathways Mediated reactions Nitroalkenes Polyphosphoric acids Synthetic study Chemistry Aksenov, A. V. Аксенов, А. В. Aksenov, D. A. Аксенов, Д. А. Griaznov, G. D. Грязнов, Г. Д. Aksenov, N. A. Аксенов, Н. А. Rubin, M. A. Рубин, М. А. Unexpected cyclization of 2-(2-aminophenyl)indoles with nitroalkenes to furnish indolo[3,2-: C] quinolines
description	The polyphosphoric acid-mediated reaction of 2-(2-aminophenyl)indenes with nitroalkenes was tested in the frame of synthetic studies towards CDK inhibitors with the paullone core. Unexpectedly, this reaction proceeded via a different mechanistic pathway affording derivatives of the natural alkaloid isocryptolepine. The scope of this unusual transformation was investigated and a mechanistic rationale explaining this outcome is offered
format	Статья
author	Aksenov, A. V. Аксенов, А. В. Aksenov, D. A. Аксенов, Д. А. Griaznov, G. D. Грязнов, Г. Д. Aksenov, N. A. Аксенов, Н. А. Rubin, M. A. Рубин, М. А.
author_facet	Aksenov, A. V. Аксенов, А. В. Aksenov, D. A. Аксенов, Д. А. Griaznov, G. D. Грязнов, Г. Д. Aksenov, N. A. Аксенов, Н. А. Rubin, M. A. Рубин, М. А.
author_sort	Aksenov, A. V.
title	Unexpected cyclization of 2-(2-aminophenyl)indoles with nitroalkenes to furnish indolo[3,2-: C] quinolines
title_short	Unexpected cyclization of 2-(2-aminophenyl)indoles with nitroalkenes to furnish indolo[3,2-: C] quinolines
title_full	Unexpected cyclization of 2-(2-aminophenyl)indoles with nitroalkenes to furnish indolo[3,2-: C] quinolines
title_fullStr	Unexpected cyclization of 2-(2-aminophenyl)indoles with nitroalkenes to furnish indolo[3,2-: C] quinolines
title_full_unstemmed	Unexpected cyclization of 2-(2-aminophenyl)indoles with nitroalkenes to furnish indolo[3,2-: C] quinolines
title_sort	unexpected cyclization of 2-(2-aminophenyl)indoles with nitroalkenes to furnish indolo[3,2-: c] quinolines
publisher	Royal Society of Chemistry
publishDate	2018
url	https://dspace.ncfu.ru:443/handle/20.500.12258/2446
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Unexpected cyclization of 2-(2-aminophenyl)indoles with nitroalkenes to furnish indolo[3,2-: C] quinolines

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