A Review of Evidence for the Involvement of the Circadian Clock Genes into Malignant Transformation of Thyroid Tissue

In 2013, the results of a pioneer study on abnormalities in the levels and circadian rhythmicity of expression of circadian clock genes in cancerous thyroid nodules was published. In the following years, new findings suggesting the involvement of circadian clock-work dysfunction into malignant trans...

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Автори:	Putilov, A. A., Путилов, А. А., Budkevich, E. V., Будкевич, Е. В., Budkevich, R. O., Будкевич, Р. О.
Формат:	Статья
Мова:	English
Опубліковано:	2023
Предмети:	Thyroid cancer Circadian clock genes Thyroid nodules Preoperative diagnostic Circadian clockwork dysfunction
Онлайн доступ:	https://dspace.ncfu.ru/handle/20.500.12258/25675
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spelling	ir-20.500.12258-256752023-10-05T13:47:27Z A Review of Evidence for the Involvement of the Circadian Clock Genes into Malignant Transformation of Thyroid Tissue Putilov, A. A. Путилов, А. А. Budkevich, E. V. Будкевич, Е. В. Budkevich, R. O. Будкевич, Р. О. Thyroid cancer Circadian clock genes Thyroid nodules Preoperative diagnostic Circadian clockwork dysfunction In 2013, the results of a pioneer study on abnormalities in the levels and circadian rhythmicity of expression of circadian clock genes in cancerous thyroid nodules was published. In the following years, new findings suggesting the involvement of circadian clock-work dysfunction into malignant transformation of thyroid tissue were gradually accumulating. This systematic review provides an update on existing evidence regarding the association of these genes with thyroid tumorigenesis. (2) Methods: Two bibliographic databases (Scopus and PubMed) were searched for articles from inception to 20 March 2023. The reference lists of previously published (nonsystematic) reviews were also hand-searched for additional relevant studies. (3) Results: Nine studies published between 2013 and 2022 were selected. In total, 9 of 12 tested genes were found to be either up- or downregulated. The list of such genes includes all families of core circadian clock genes that are the key components of three transcriptional–translational feedback loops of the circadian clock mechanism (BMAL1, CLOCK, NPAS2, RORα, REV-ERBα, PERs, CRYs, and DECs). (4) Conclusions: Examination of abnormalities in the levels and circadian rhythmicity of expression of circadian clock genes in thyroid tissue can help to reduce the rate of inadequate differential preoperative diagnosis for thyroid carcinoma. 2023-10-05T13:46:35Z 2023-10-05T13:46:35Z 2023 Статья Putilov, A.A.; Budkevich, E.V.; Budkevich, R.O. A Review of Evidence for the Involvement of the Circadian Clock Genes into Malignant Transformation of Thyroid Tissue // Clocks&Sleep. - 2023. - 5, рр. 384–398. - DOI: 10.3390/clockssleep5030029 http://hdl.handle.net/20.500.12258/25675 en Clocks&Sleep application/pdf
institution	СКФУ
collection	Репозиторий
language	English
topic	Thyroid cancer Circadian clock genes Thyroid nodules Preoperative diagnostic Circadian clockwork dysfunction
spellingShingle	Thyroid cancer Circadian clock genes Thyroid nodules Preoperative diagnostic Circadian clockwork dysfunction Putilov, A. A. Путилов, А. А. Budkevich, E. V. Будкевич, Е. В. Budkevich, R. O. Будкевич, Р. О. A Review of Evidence for the Involvement of the Circadian Clock Genes into Malignant Transformation of Thyroid Tissue
description	In 2013, the results of a pioneer study on abnormalities in the levels and circadian rhythmicity of expression of circadian clock genes in cancerous thyroid nodules was published. In the following years, new findings suggesting the involvement of circadian clock-work dysfunction into malignant transformation of thyroid tissue were gradually accumulating. This systematic review provides an update on existing evidence regarding the association of these genes with thyroid tumorigenesis. (2) Methods: Two bibliographic databases (Scopus and PubMed) were searched for articles from inception to 20 March 2023. The reference lists of previously published (nonsystematic) reviews were also hand-searched for additional relevant studies. (3) Results: Nine studies published between 2013 and 2022 were selected. In total, 9 of 12 tested genes were found to be either up- or downregulated. The list of such genes includes all families of core circadian clock genes that are the key components of three transcriptional–translational feedback loops of the circadian clock mechanism (BMAL1, CLOCK, NPAS2, RORα, REV-ERBα, PERs, CRYs, and DECs). (4) Conclusions: Examination of abnormalities in the levels and circadian rhythmicity of expression of circadian clock genes in thyroid tissue can help to reduce the rate of inadequate differential preoperative diagnosis for thyroid carcinoma.
format	Статья
author	Putilov, A. A. Путилов, А. А. Budkevich, E. V. Будкевич, Е. В. Budkevich, R. O. Будкевич, Р. О.
author_facet	Putilov, A. A. Путилов, А. А. Budkevich, E. V. Будкевич, Е. В. Budkevich, R. O. Будкевич, Р. О.
author_sort	Putilov, A. A.
title	A Review of Evidence for the Involvement of the Circadian Clock Genes into Malignant Transformation of Thyroid Tissue
title_short	A Review of Evidence for the Involvement of the Circadian Clock Genes into Malignant Transformation of Thyroid Tissue
title_full	A Review of Evidence for the Involvement of the Circadian Clock Genes into Malignant Transformation of Thyroid Tissue
title_fullStr	A Review of Evidence for the Involvement of the Circadian Clock Genes into Malignant Transformation of Thyroid Tissue
title_full_unstemmed	A Review of Evidence for the Involvement of the Circadian Clock Genes into Malignant Transformation of Thyroid Tissue
title_sort	review of evidence for the involvement of the circadian clock genes into malignant transformation of thyroid tissue
publishDate	2023
url	https://dspace.ncfu.ru/handle/20.500.12258/25675
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A Review of Evidence for the Involvement of the Circadian Clock Genes into Malignant Transformation of Thyroid Tissue

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