Morphofunctional condition of bones and hippocampus of white rats at experimental intoxication with aluminium chloride

It is established that use of aluminium chloride in a dose of 100 mg/kg Bw brings essential changes in the CNS and skeletal system. So, there are essential changes in population of neurons of a hippocampus of rats, particularly, the significant increase of the quantity of chromatolyzed, hyperchromic...

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Autors principals:	Timchenko, L. D., Тимченко, Л. Д., Rzhepakovsky, I. V., Ржепаковский, И. В.
Format:	Статья
Idioma:	English
Publicat:	Research Journal of Pharmaceutical, Biological and Chemical Sciences 2018
Matèries:	Aluminium Alzheimer's disease Hypercalcaemia Neuron
Accés en línia:	https://www.scopus.com/record/display.uri?eid=2-s2.0-85030176181&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=eb0fd8958262e0119df2d3be7360e0ef&sot=aff&sdt=sisr&sl=145&s=AF-ID%28%22North+Caucasus+Federal+University%22+60070541%29+OR+AF-ID%28%22%5bNo+Affiliation+ID+found%5d%22+60070961%29+OR+AF-ID%28%22%5bNo+Affiliation+ID+found%5d%22+60026323%29&ref=%28Morphofunctional+Condition+of+Bones+and+Hippocampus+of+White+Rats+at+Experimental%29&relpos=0&citeCnt=1&searchTerm= https://dspace.ncfu.ru/handle/20.500.12258/2602
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spelling	ir-20.500.12258-26022020-07-06T12:46:57Z Morphofunctional condition of bones and hippocampus of white rats at experimental intoxication with aluminium chloride Timchenko, L. D. Тимченко, Л. Д. Rzhepakovsky, I. V. Ржепаковский, И. В. Aluminium Alzheimer's disease Hypercalcaemia Neuron It is established that use of aluminium chloride in a dose of 100 mg/kg Bw brings essential changes in the CNS and skeletal system. So, there are essential changes in population of neurons of a hippocampus of rats, particularly, the significant increase of the quantity of chromatolyzed, hyperchromic and wrinkled neurons. Such changes in general are a characteristic symptom of Alzheimer's disease. At the same time, decrease in trabecular bone mineral density at Al-treated rats against the background of the pattern of change of the value BV/TV demonstrates that trabecular bone mineral density goes down due to reduction of salts of calcium in favor of what also increase in level of a calcaemia at animals of this group testifies. Thus, the influence of AlCl3 leads to a decrease in trabecular bone mineral density, and, as a result, to development of hypercalcaemia 2018-07-30T13:19:23Z 2018-07-30T13:19:23Z 2017 Статья Areshidze, D.A., Timchenko, L.D., Rzhepakovsky, I.V., Kozlova, M.A., Syomin, I.A., Kuznetsova, I.A. Morphofunctional condition of bones and hippocampus of white rats at experimental intoxication with aluminium chloride // Research Journal of Pharmaceutical, Biological and Chemical Sciences. - 2017. - Volume 8. - Issue 1. - Pages 1411-1417 https://www.scopus.com/record/display.uri?eid=2-s2.0-85030176181&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=eb0fd8958262e0119df2d3be7360e0ef&sot=aff&sdt=sisr&sl=145&s=AF-ID%28%22North+Caucasus+Federal+University%22+60070541%29+OR+AF-ID%28%22%5bNo+Affiliation+ID+found%5d%22+60070961%29+OR+AF-ID%28%22%5bNo+Affiliation+ID+found%5d%22+60026323%29&ref=%28Morphofunctional+Condition+of+Bones+and+Hippocampus+of+White+Rats+at+Experimental%29&relpos=0&citeCnt=1&searchTerm= http://hdl.handle.net/20.500.12258/2602 en Research Journal of Pharmaceutical, Biological and Chemical Sciences application/pdf application/pdf Research Journal of Pharmaceutical, Biological and Chemical Sciences
institution	СКФУ
collection	Репозиторий
language	English
topic	Aluminium Alzheimer's disease Hypercalcaemia Neuron
spellingShingle	Aluminium Alzheimer's disease Hypercalcaemia Neuron Timchenko, L. D. Тимченко, Л. Д. Rzhepakovsky, I. V. Ржепаковский, И. В. Morphofunctional condition of bones and hippocampus of white rats at experimental intoxication with aluminium chloride
description	It is established that use of aluminium chloride in a dose of 100 mg/kg Bw brings essential changes in the CNS and skeletal system. So, there are essential changes in population of neurons of a hippocampus of rats, particularly, the significant increase of the quantity of chromatolyzed, hyperchromic and wrinkled neurons. Such changes in general are a characteristic symptom of Alzheimer's disease. At the same time, decrease in trabecular bone mineral density at Al-treated rats against the background of the pattern of change of the value BV/TV demonstrates that trabecular bone mineral density goes down due to reduction of salts of calcium in favor of what also increase in level of a calcaemia at animals of this group testifies. Thus, the influence of AlCl3 leads to a decrease in trabecular bone mineral density, and, as a result, to development of hypercalcaemia
format	Статья
author	Timchenko, L. D. Тимченко, Л. Д. Rzhepakovsky, I. V. Ржепаковский, И. В.
author_facet	Timchenko, L. D. Тимченко, Л. Д. Rzhepakovsky, I. V. Ржепаковский, И. В.
author_sort	Timchenko, L. D.
title	Morphofunctional condition of bones and hippocampus of white rats at experimental intoxication with aluminium chloride
title_short	Morphofunctional condition of bones and hippocampus of white rats at experimental intoxication with aluminium chloride
title_full	Morphofunctional condition of bones and hippocampus of white rats at experimental intoxication with aluminium chloride
title_fullStr	Morphofunctional condition of bones and hippocampus of white rats at experimental intoxication with aluminium chloride
title_full_unstemmed	Morphofunctional condition of bones and hippocampus of white rats at experimental intoxication with aluminium chloride
title_sort	morphofunctional condition of bones and hippocampus of white rats at experimental intoxication with aluminium chloride
publisher	Research Journal of Pharmaceutical, Biological and Chemical Sciences
publishDate	2018
url	https://www.scopus.com/record/display.uri?eid=2-s2.0-85030176181&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=eb0fd8958262e0119df2d3be7360e0ef&sot=aff&sdt=sisr&sl=145&s=AF-ID%28%22North+Caucasus+Federal+University%22+60070541%29+OR+AF-ID%28%22%5bNo+Affiliation+ID+found%5d%22+60070961%29+OR+AF-ID%28%22%5bNo+Affiliation+ID+found%5d%22+60026323%29&ref=%28Morphofunctional+Condition+of+Bones+and+Hippocampus+of+White+Rats+at+Experimental%29&relpos=0&citeCnt=1&searchTerm= https://dspace.ncfu.ru/handle/20.500.12258/2602
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Morphofunctional condition of bones and hippocampus of white rats at experimental intoxication with aluminium chloride

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